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IN FOCUS: Solvias

Pharmaceutical Technology

Beyond our expertise in small molecules, we have built a solid reputation with biopharmaceutical companies for the characterisation and analysis of monoclonal antibodies, therapeutic proteins and biosimilars. Solvias is well equipped to provide stability testing for all stages of drug development. HQ ADDRESS: Römerpark 2. 4303 Kaiseraugst.

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Treatment of Metastatic Triple-Negative Breast Cancer

The Pharma Data

SG is a first-in-class therapy targeting Trop-2, a protein frequently expressed in multiple types of epithelial tumors, such as TNBC, where high expression is associated with poor survival and relapse. SG contains a genotoxic component and can cause teratogenicity and/or embryo-fetal lethality when administered to a pregnant woman.

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Packaging Solutions for Pharmaceuticals & Medical Devices: Insights and Considerations

XTalks

This highly sensitive method even works to detect package defects clogged by product formulation proteins or salts, explains Liss. If they do, the FDA will assume the worst-case scenario and deem the compound or fragment to be genotoxic or eugenic. Tox Tree and grouping by Cramer rules are starting to lose favor with the FDA.

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Trodelvy®, the First Treatment for Metastatic Triple-Negative Breast Cancer Shown to Improve Progression-Free Survival and Overall Survival

The Pharma Data

Trodelvy is directed to the Trop-2 receptor, a protein frequently expressed in multiple types of epithelial tumors, including TNBC, where high expression is associated with poor survival and relapse. TRODELVY contains a genotoxic component, SN-38, and targets rapidly dividing cells. months vs. 6.9 months (HR: 0.51; 95% CI: 0.41-0.62;

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Trodelvy® for the Treatment of Metastatic Urothelial Cancer

The Pharma Data

TRODELVY contains a genotoxic component, SN-38, and targets rapidly dividing cells. More information on TROPiCS-04 is available at [link]. About Trodelvy. Embryo-Fetal Toxicity: Based on its mechanism of action, TRODELVY can cause teratogenicity and/or embryo-fetal lethality when administered to a pregnant woman.

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Let's Quit Sugar With Audiobook – Let's Quit Sugar

The Pharma Data

Exposure to sorbitol during lactation causes metabolic alterations and genotoxic effects in rat offspring. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1120794109.

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