Scienmag

JUNE 18, 2025

In a groundbreaking new study, scientists have unveiled a comprehensive map detailing the mutagenesis sensitivity of human developmental enhancers in vivo, shedding unprecedented light on the intricate sequence architecture that governs gene regulation during human development.

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In-Vivo Gene Expression Gene DNA 80

Worldwide Clinical Trials

DECEMBER 19, 2024

In-Vitro Diagnostic Regulation and The FDAs Final Rule The WODC U.S. discussion also briefly mentioned the FDAs Final Rule, which seems to run parallel with the EUs In-Vitro Diagnostic Regulation (IVDR). One topic that sparked this dialogue is the potential bankruptcy of 23andMe, a direct-to-consumer genetic testing company.

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Genetics In-Vitro Clinical Trials Clinical Trials 130

Scienmag

JULY 3, 2025

Conversely, forced overexpression of XPR1 augmented proliferative and metastatic capabilities in vitro. Scientists at Chongqing Medical University have identified XPR1 as a key regulator of autophagy—a cellular degradation and recycling process—and as a modulator of major histocompatibility complex class I (MHC-I) expression.

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Regulation Gene Gene Editing RNA 59

Scienmag

JUNE 10, 2025

Cell lines often lose critical tumor-specific features through prolonged in vitro culture, but PDXs maintain the malignant phenotype in vivo, providing a more faithful and clinically relevant experimental framework. Despite their promise, PDX models confront substantial hurdles that have limited their widespread adoption.

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Research Clinical Trials Clinical Trials Gene Editing 59

Scienmag

JULY 3, 2025

The researchers conducted meticulous in vivo and in vitro experiments demonstrating that binge alcohol exposure upregulates VGLUT3 expression in Kupffer cells. The liver is a vital organ responsible for detoxifying harmful substances, metabolizing drugs, and maintaining metabolic homeostasis.

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In-Vivo Genetics In-Vitro Gene Expression 52

Scienmag

JUNE 20, 2025

In a groundbreaking in vitro study published in BioMedical Engineering OnLine, researchers have explored the biomechanical consequences of constrained versus free humeral rotation during active shoulder elevation. Interestingly, smaller tears did not universally lead to increased humeral rotation or loading of the infraspinatus.

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In-Vitro In-Vivo Research Engineer 52

Scienmag

JUNE 30, 2025

In the evolving landscape of biomedical materials, renewable polymers derived from natural sources have attracted significant scientific interest. The quest for sustainable and biocompatible materials has positioned polymers such as vegetable-derived cellulose, bacterial cellulose, chitosan, and starch at the forefront of cutting-edge research.

Medicine 87

Medicine Drug Delivery Systems Drug Delivery Engineer 87

Scienmag

JUNE 17, 2025

Their joint effort employs brain organoids—miniaturized and simplified versions of the human brain grown in vitro from patient-derived cells—providing a unique and physiologically relevant platform to model human neurodegeneration with unprecedented fidelity. His groundbreaking project, DIMERCIRCUITS, backed by a prestigious €2.5

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Genetics Gene Therapy Gene Expression Gene 59

Scienmag

JUNE 17, 2025

In the rapidly evolving field of neonatal pharmacology, recent insights into the use of ethanol as an excipient in common medications have sparked significant scientific discussion. The study conducted by Zhou, K.Q., Millward, L., The study conducted by Zhou, K.Q., Millward, L.,

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In-Vitro Drugs Bioavailability Research 59

Scienmag

JULY 16, 2025

Demonstrating this, the research team generated Slide-seq spatial transcriptomic data from an in vitro human developmental model. In the rapidly evolving landscape of developmental biology, understanding how cells transition from one fate to another within the complex milieu of a living tissue remains one of the most formidable challenges.

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Gene Expression Gene RNA In-Vitro 59

Scienmag

JUNE 29, 2025

A groundbreaking international study unveiled at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has illuminated a critical yet often underestimated factor influencing reproductive success: paternal age. However, pronounced disparities emerged during the subsequent clinical stages.

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DNA Genetics In-Vitro Gene Expression 59

Scienmag

JULY 9, 2025

These in vitro models emphasize the causal linkage between cellular stress signatures and functional impairment, offering a valuable platform to assess potential pharmacological strategies aimed at rescuing progenitor function.

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Gene Expression Gene In-Vivo In-Vitro 59

Scienmag

JULY 3, 2025

In the relentless pursuit to decipher the molecular underpinnings of bladder cancer, a groundbreaking study has unveiled a pivotal role of the transcription factor TCF3 in orchestrating tumor progression through a novel ferroptosis-dependent pathway.

Regulation 59

Regulation Gene In-Vivo In-Vitro 59

Scienmag

JUNE 23, 2025

The DNA barcodes can be activated and recorded in vivo in living mice, thereby preserving the natural developmental environment and avoiding the artifacts associated with in vitro studies. The essence of LoxCode lies in its ingenious use of DNA barcoding to uniquely mark each cell within a genetically engineered mouse.

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In-Vivo DNA Genetic Engineering Genetics 52

BioTech 365

JUNE 19, 2025

CancerVax Nanoparticle Successfully Targets Cancer Cells While Sparing Non-cancerous Cells CancerVax Nanoparticle Successfully Targets Cancer Cells While Sparing Non-cancerous Cells In-vitro lab results confirmed that the Company’s cell targeting nanoparticles successfully entered cancer cells and avoided non-cancerous cells Lehi, June … Continue (..)

In-Vitro 52

In-Vitro 52

Scienmag

JUNE 23, 2025

While they drastically impaired or killed melanoma cells cultured in vitro, non-cancerous skin cells remained largely unaffected. A groundbreaking discovery in melanoma research has unveiled a crucial biological vulnerability in this notoriously aggressive form of skin cancer. The implications of these discoveries extend beyond melanoma.

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Protein Drugs In-Vitro Production 86

Scienmag

JUNE 30, 2025

Importantly, the research employs both in vitro cell culture models and in vivo murine tumor xenografts to validate the relevance of SH3BGRL-mediated engulfment in cancer progression. However, mutations within the TP53 gene—a hallmark in a vast majority of human cancers—transform this protective sentinel into a driver of malignancy.

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Protein Gene In-Vivo In-Vitro 59

Scienmag

JUNE 21, 2025

This study employed advanced molecular biology techniques alongside rigorous in vitro and in vivo models of NSCLC to map the Nrf2-HMOX1 axis’s function and its impact on cisplatin responsiveness. Cisplatin remains a cornerstone chemotherapeutic agent for NSCLC, yet its efficacy is severely limited by the rapid emergence of drug resistance.

Regulation 52

Regulation In-Vivo In-Vitro Research 52

Scienmag

JUNE 9, 2025

In the intricate microcosm of biological systems, the extracellular matrix (ECM) serves as a dynamic and structural scaffold, orchestrating a symphony of cellular behaviors critical to tissue function and regeneration. A pivotal innovation in this model lies in the incorporation of covalent crosslinking domains.

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Engineer Protein In-Vivo In-Vitro 86

Scienmag

JUNE 21, 2025

Importantly, the study utilises a combination of in vitro glioblastoma models, patient-derived cells, and in vivo murine systems to validate these findings. This unexpected duality challenges existing paradigms around cell death pathways in cancer and opens novel avenues for therapeutic intervention.

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In-Vivo In-Vitro Bioinformatics Research 72

Scienmag

JUNE 10, 2025

Candidate bnAbs identified through in silico screening underwent rigorous in vitro neutralization assays against panels of SARS-CoV-2 variants, including the notorious alpha, beta, delta, and omicron lineages. Experimental validation played a pivotal role in confirming computational predictions.

Antibody 59

Antibody Protein In-Vitro Vaccination 59

Scienmag

JUNE 12, 2025

Existing in vitro models focus on interactions between T cells, B cells, and dendritic cells, rather than stromal cells. Working with scientists at the University of Virginia, the researchers are building a bioengineered model of a human lymph node, which performs essential roles in the immune system throughout the body.

Medicine 87

Medicine Research Engineer Immune Response 87

Pharma Times

JULY 10, 2025

This change follows strong support for a proposal to repeal the Coronavirus Test Device Approval (CTDA) process in favour of EU-aligned standards. An accelerated CTDA process will be introduced in the interim for COVID-19 devices carrying CE marking under European IVD rules and meeting Common Specification criteria.

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In-Vitro Regulation Trials Vaccination 116

Scienmag

JUNE 21, 2025

Preliminary in vitro assays demonstrated compelling efficacy in promoting ribosomal read-through across multiple Fanconi anemia-associated gene transcripts, fostering the generation of near-native full-length proteins. The development pipeline of these TRIDs reflects extensive biochemical and pharmacological innovation.

Drugs 59

Drugs Genetics Protein DNA 59

XTalks

NOVEMBER 25, 2024

XTALKS WEBINAR: Enhance Early Biomarker Discovery: Translating In Vitro and In Vivo Multi-Omics Oncology Data Live and On-Demand: Thursday, January 16, 2025, at 11am EST (4pm GMT/UK) Register for this free webinar to learn how to harness the full potential of multi-omics data and advanced patient models to drive early biomarker discovery.

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In-Vivo FDA Approval In-Vitro Drugs 105

Scienmag

JUNE 29, 2025

This pioneering research elucidates previously unexplored biological mechanisms contributing to reproductive challenges faced by millions of women worldwide, potentially reshaping future clinical strategies in reproductive healthcare. merdae) in women with PCOS. Of particular note was the diminished presence of P.

In-Vitro 59

In-Vitro Research Bacterium Regulation 59

XTalks

JANUARY 21, 2025

From non-invasive cancer diagnostics to life-saving cardiovascular implants, the latest medical devices cleared or approved by the FDA in 2024 reflect the remarkable strides in science and engineering. In this blog, we discuss some of these new medical devices of 2024 that have improved patient outcomes and enhanced quality of life worldwide.

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FDA Approval Manufacturing RNA Development 105

Scienmag

JULY 5, 2025

The research team employed both genetically modified mouse models and in vitro assays to determine that restoring or augmenting FGF13 levels significantly attenuates neuronal loss and synaptic disassembly.

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In-Vitro Research Protein Gene Therapy 59

Scienmag

JULY 3, 2025

The functional consequences of FL3-mediated mitochondrial fusion were examined using both in vitro cardiomyocyte models and in vivo rodent models of cardiac ischemia-reperfusion. These events culminate in cell death pathways, inflammation, and ultimately impaired cardiac function. The team led by Zhong, Z.,

In-Vivo 52

In-Vivo In-Vitro Gene Expression Cardiology 52

XTalks

JANUARY 13, 2025

XTALKS WEBINAR: Enhance Early Biomarker Discovery: Translating In Vitro and In Vivo Multi-Omics Oncology Data Live and On-Demand: Thursday, January 16, 2025, at 11am EST (4pm GMT/UK) Register for this free webinar to learn how to drive early biomarker discovery by harnessing the full potential of multi-omics data and advanced patient models.

Immune Response 105

Immune Response In-Vivo In-Vitro Development 105

Scienmag

JUNE 20, 2025

In a groundbreaking study emerging from Kyushu University, researchers have unveiled a previously unrecognized role for the histone modification H3K4me3 in the maturation and developmental competence of mouse oocytes. High-resolution immunofluorescence microscopy revealed a remarkable asymmetric accumulation of H3K4me3 in MII oocytes.

Gene Expression 59

Gene Expression Gene Regulation In-Vitro 59

XTalks

MAY 22, 2025

The FDA has granted 510(k) clearance to Fujirebio Diagnostics Lumipulse G pTau217/-Amyloid 1-42 Plasma Ratio, the first in vitro diagnostic blood test approved to aid in the diagnosis of Alzheimers disease. The test is cleared for use in adults aged 55 years and older who exhibit cognitive symptoms of Alzheimers.

In-Vitro 59

In-Vitro Clinical Trials Clinical Trials Radiology 59

Scienmag

JUNE 21, 2025

Beyond molecular mechanistic revelations, the physiological implications of truncated LKB1’s pro-apoptotic role were probed in vitro and in vivo models. Apoptosis, a tightly controlled cellular process of programmed cell death, is essential for maintaining cellular homeostasis and sculpting organismal development.

Protein 59

Protein Regulation In-Vivo In-Vitro 59

XTalks

DECEMBER 6, 2024

XTALKS WEBINAR: Enhance Early Biomarker Discovery: Translating In Vitro and In Vivo Multi-Omics Oncology Data Live and On-Demand: Thursday, January 16, 2025 , at 11am EST (4pm GMT / UK) Register for this free webinar to explore the critical role of early biomarker identification in de-risking drug candidates and increasing clinical success rates.

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Gene In-Vivo In-Vitro Genetics 98

STAT News

JUNE 16, 2025

With 1 in 6 globally experiencing infertility , the current administration’s presidential order to make in vitro fertilization more affordable was a welcome development. In the face of rising national infertility and economic uncertainty, the institution of family is more important than ever.

Doctors 67

Doctors Doctor Regulation In-Vitro 67

Pharmaceutical Technology

JUNE 20, 2025

GlobalData Healthcare June 20, 2025 Share Copy Link Share on X Share on Linkedin Share on Facebook According to a Novo Nordisk’s speaker at the conference, the company aims to utilise human data input into its target discovery engine.

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Development Drugs In-Vitro Clinical Trials 147

pharmaphorum

JULY 14, 2025

Skip to main content Monday 14 July 2025 BlueSky linkedin youtube rss User account menu Subscribe Channels Channels Digital Market Access Oncology Patients R&D Sales & Marketing Spotlight on Content type Content type Digital -News -Views & Analysis -Deep Dive -Webinars -Podcasts -Video -White Papers -Event Market Access -News -Views & (..)

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Sales Marketing Life Science In-Vivo 52