Scienmag

JUNE 19, 2025

Their research, recently published in ACS Applied Materials & Interfaces , unveils a sophisticated coassembly of a medical-grade polymer, PLGA (poly(lactic-co-glycolic acid)), with the naturally abundant blood protein albumin, culminating in an innovative drug carrier marked by unprecedented stability and drug-loading capacity.

Drug Delivery 72

Drug Delivery Drugs Drug Delivery Systems Protein 72

Scienmag

JUNE 23, 2025

The study identifies the gene TATA-box binding protein associated factor 2 (TAF2) as a critical driver in hepatocyte survival and hepatocellular tumorigenesis, heralding new avenues for targeted therapy development. Given these foundational findings, Dr. Sarkar is now poised to transition from discovery to translational medicine.

Genetics 92

Genetics Scientist Gene Protein 92

The Pharma Data

JUNE 24, 2025

The strategic funding arrangement is designed to support the continued advancement and global commercialization of Revolution Medicines’ RAS(ON) inhibitor portfolio, including its lead candidate daraxonrasib, as the company scales its operations independently across the international oncology market.

Medicine 40

Medicine Development Drugs Protein 40

Scienmag

JUNE 14, 2025

The efficiency of solute clearance in the brain is crucial, as accumulation of misfolded proteins like alpha-synuclein is implicated in Parkinson’s pathology. These alterations could facilitate the buildup of neurotoxic proteins and inflammatory mediators, creating a self-propagating cycle of neural injury.

Protein 59

Protein Research Medicine Trials 59

Scienmag

JULY 1, 2025

This approach circumvents direct genetic modification to embed photosensitive domains within CRISPR proteins themselves, simplifying the platform and improving compatibility with existing CRISPR tools. Such developments accelerate the realization of personalized medicine, synthetic gene networks, and advanced biological research tools.

Gene Editing 59

Gene Editing Gene Gene Therapy Genomics 59

Scienmag

JULY 7, 2025

The methodology harnessed directed evolution, a powerful strategy that mimics natural selection to generate protein variants with desired properties. This will improve the translational relevance of preclinical models, uncover novel genotype-specific drug responses, and elucidate mechanisms of disease resistance to precision medicine.

Genomics 59

Genomics Genome Genotype Engineer 59

Pharmaceutical Technology

JUNE 26, 2025

Indeed, in 2024, the Nobel Prize in Chemistry was awarded to the DeepMind team for their work on AlphaFold [ii] , an AI system that accurately predicts protein structures. Generative AI, for instance, is being used to create small molecules or proteins that meet specific criteria, enhancing the drug design process [iii].

Drugs 216

Drugs Clinical Trials Clinical Trials Life Science 216

Scienmag

JUNE 9, 2025

Now, a visionary team of researchers has leveraged this insight to engineer a minimalistic, designer molecular model that not only recapitulates but also harnesses the phase-separation-mediated assembly of ECM, unfolding striking implications for biomaterial science and regenerative medicine.

Engineer 86

Engineer Protein In-Vivo In-Vitro 86

Pharmaceutical Technology

JUNE 19, 2025

BioOrbit aims to kick off pre-clinical trials to study protein crystals for monoclonal antibodies (mAbs) produced in a pharmaceutical factory in space in 2026. Image credit: Rini. com/ Shutterstock.

Clinical Trials 130

Clinical Trials Clinical Trials Manufacturing Protein 130

Scienmag

JULY 15, 2025

In vivo experiments demonstrated that bacterial calcification stimulates the upregulation of calprotectin proteins—specifically S100A8 and S100A9—in macrophages and monocytes. Beyond the bactericidal effects, the study reveals compelling immunomodulatory outcomes induced by this novel therapeutic strategy.

Antibody 59

Antibody Immune Response Bacteria In-Vivo 59

Scienmag

JUNE 19, 2025

Theresa Hunter and her team have pioneered a transformative method whereby lipid nanoparticles, engineered with a novel ionizable lipid designated L829, are conjugated with antibodies targeting CD5—a protein prominently expressed on T cells.

In-Vivo 52

In-Vivo Engineer Manufacturing DNA 52

Scienmag

JUNE 17, 2025

Guided by this insight, the researchers further characterized HV tumors and uncovered the consistent expression of TM4SF1, a transmembrane protein implicated in tumor progression and metastasis. This unexpected discovery of CA125 expression in bladder tumors challenged existing paradigms and opened new therapeutic avenues.

Genomics 59

Genomics Genome Clinical Trials Clinical Trials 59

Scienmag

JUNE 16, 2025

These nanoneedles gently penetrate the tissue surface to acquire a spectrum of molecular data — including lipids, proteins, and mRNA — creating a high-resolution, multidimensional fingerprint of the tissue’s biochemical environment. The speed at which the nanoneedle patch can deliver results is another game-changing aspect.

Scientist 59

Scientist Life Science Research Clinical Trials 59

The Pharma Data

JUNE 24, 2025

Royalty Pharma and Revolution Medicines Forge $2 Billion Strategic Funding Pact to Accelerate Global Development of RAS Cancer Therapies Royalty Pharma plc, a prominent funder of innovation in the biopharmaceutical industry, announced a transformative agreement with Revolution Medicines, Inc.,

Medicine 40

Medicine Clinical Development Packaging Packaging 40

Scienmag

JULY 3, 2025

CAR-T cell therapies, by genetically engineering patients’ own T cells to express receptors specific to BCMA—a surface protein highly expressed on malignant plasma cells—have revolutionized treatment paradigms.

FDA Approval 85

FDA Approval Genetic Engineering Engineer Production 85

Scienmag

JUNE 13, 2025

Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in the University of Cincinnati’s Center for Advanced Structural Biology — potentially opening the door for better designed therapeutics. We are indebted to UC,” said Seegar.

Research 98

Research Protein Life Science Regulation 98

Scienmag

JUNE 27, 2025

Notably, immunohistochemical analysis revealed low-level HER2 protein expression despite DNA-level mutations, a finding underscored by dual in situ hybridization techniques confirming the absence of gene amplification. The disparity in treatment outcomes was stark.

Genetics 59

Genetics Genomics Genome Protein 59

Scienmag

JUNE 22, 2025

Historically, nutritional protocols have emphasized protein and carbohydrate provision; however, lipids—especially essential fatty acids—have been relatively understudied despite their known roles in myelination and synaptic formation.

Research 59

Research Development Production Medicine 59

Bioengineer

JANUARY 22, 2025

He suggests that increasing physical activity and protein intake in the weeks leading up to surgery can markedly shorten the post-operative recovery period for patients. The Ottawa Hospital is currently spearheading multi-center prehabilitation trials led by the Aging Innovation In Perioperative Medicine & Surgery (AIMS) Research Group.

Trials 59

Trials Clinical Trials Clinical Trials Research 59

XTalks

JANUARY 7, 2025

Symvess is a one-time, single-use, acellular tissue-engineered vessel (ATEV) composed of human extracellular matrix proteins. Manufactured using vascular smooth muscle cells derived from human aortic tissue, Symvess offers a novel solution for patients with traumatic vascular injuries.

FDA Approval 105

FDA Approval Engineer Clinical Trials Clinical Trials 105

Scienmag

JULY 3, 2025

Central to the discovery is VGLUT3, or vesicular glutamate transporter 3, a protein traditionally recognized for loading glutamate—a principal excitatory neurotransmitter—into synaptic vesicles in the nervous system. Intriguingly, this transporter is also expressed in Kupffer cells, the liver’s resident immune sentinels.

In-Vivo 52

In-Vivo Genetics In-Vitro Gene Expression 52

Scienmag

JULY 2, 2025

This battery involved twelve distinct cytokines, C-reactive protein (CRP), and cholinesterase (ChE). Personalized medicine approaches could emerge, integrating neurochemical biomarkers with clinical characteristics to customize ECT pulse parameters, maximizing benefits while minimizing adverse effects.

Research 96

Research Compliance Protein Medicine 96

Scienmag

JUNE 18, 2025

The study, conducted in mice, demonstrated that vaccines crafted with both alum and SMNP not only penetrate lymph node barriers effectively but also maintain the integrity of the HIV antigen—specifically the engineered MD39 protein—for extended periods, up to 28 days.

Vaccine 90

Vaccine Vaccination Immune Response Antibody 90

XTalks

DECEMBER 10, 2024

Rilzabrutinib works by targeting BTK, a protein involved in immune cell communication. By inhibiting this protein, the drug disrupts pathways that contribute to platelet destruction and insufficient production. percent platelet response in a study published in The New England Journal of Medicine.

Trials 104

Trials Protein Clinical Development Drugs 104

XTalks

FEBRUARY 5, 2025

Avtozma is a recombinant humanized monoclonal antibody that acts as an interleukin 6 (IL-6) receptor antagonist that works by targeting specific inflammatory proteins to dampen immune responses. Avtozma was submitted for regulatory approval to the FDA in January 2024 and the European Medicines Agency (EMA) in February 2024.

FDA Approval 102

FDA Approval Marketing Antibody Immune Response 102

Scienmag

JUNE 30, 2025

These primate models express tau protein isoforms analogous to humans, unlike rodent models, thereby providing enhanced translational validity. Her interview and detailed research overview are freely accessible in the open access journal Brain Medicine, published by Genomic Press.

Research 66

Research Protein Genomics Genome 66

Scienmag

JULY 4, 2025

Connexin 43, traditionally known as a gap junction protein facilitating intercellular communication, has recently come under the scientific spotlight for its multifunctional role in cancer biology. The current research identifies Cx43 as a crucial enhancer of cancer cell sensitivity to inhibitors targeting the BRAF/MEK signaling axis.

DNA 100

DNA HR Protein Genotoxicity 100

Scienmag

JUNE 27, 2025

Over time, these cells began producing fundamental milk components, such as β-casein—a key milk protein—and milk fat globules, effectively recapitulating aspects of human milk synthesis in vitro. Remarkably, the epithelial cells settled on the interior surfaces of the printed ducts and proliferated, forming a dense, functional cell layer.

In-Vitro 59

In-Vitro Engineer Production Research 59

Scienmag

JUNE 24, 2025

Botulinum toxin, a neurotoxic protein widely known for its neuromuscular blockade properties, is administered via ultrasound-guided injections into the major salivary glands – specifically the parotid and submandibular glands – on alternate sides of the body. National University of Singapore, Singapore / Richard P. Baum et al.,

Botox 59

Botox FDA Approval Medicine Protein 59

Scienmag

JULY 3, 2025

The study also meticulously investigates the inflammatory and lipid-related pathways mediating this relationship, highlighting C-reactive protein (CRP) and the atherogenic index of plasma (AIP) as key players.

Protein 66

Protein Insulin Research Hormones 66

Scienmag

JUNE 7, 2025

By measuring circulating cytokines, chemokines, and acute-phase proteins, the researchers were able to draw correlations with cognitive performance metrics and motor symptom scales, revealing nuanced relationships. Inflammatory mediators may facilitate alpha-synuclein propagation or exacerbate its toxicity, further driving neurodegeneration.

Research 89

Research Clinical Trials Clinical Trials Genetics 89

XTalks

JANUARY 21, 2025

The approval makes Datroway AstraZenecas eighth new medicine since 2020, the first US approval for Daiichi Sankyo and AstraZenecas TROP2-directed ADC and the second based on their proprietary DXd technology. The FDA approval sent Daiichi Sankyos shares soaring by 8.7% to 4,437 yen, reflecting investor confidence.

Antibody 105

Antibody FDA Approval HR Trials 105

Scienmag

JULY 2, 2025

Their data revealed that Rev-erbα coordinates the temporal expression of genes involved in oxidative metabolism, protein turnover, and nutrient sensing pathways. By identifying Rev-erbα as a gatekeeper of time-dependent muscle adaptation, the study opens exciting possibilities for exploiting circadian biology in exercise medicine.

Gene Expression 59

Gene Expression Gene Regulation In-Vivo 59

Scienmag

JULY 16, 2025

Importantly, antagonists selective for I1R, such as AGN192403, demonstrated a potent blockade of ImP-induced phosphorylation of the ribosomal protein S6 (p-S6), an mTOR pathway hallmark, and the secretion of the key inflammatory cytokine tumor necrosis factor (TNF).

Gene Expression 69

Gene Expression Genetics Protein Immune Response 69

Scienmag

JUNE 18, 2025

Researchers Uncover Key Mechanism Behind PARP Inhibitor Resistance in BRCA1-Deficient Cancers In a groundbreaking discovery poised to transform cancer therapy, scientists have identified a crucial protein complex that influences resistance to PARP inhibitors in cancers harboring BRCA1 mutations.

DNA 69

DNA Scientist Drugs Genotoxicity 69

Scienmag

JULY 9, 2025

Concurrently, stressed mural cells elevated levels of ADAMTS1, a protein notorious for its anti-angiogenic properties and facilitation of pericyte detachment leading to capillary rarefaction. Subject of Research : Cellular and molecular remodeling of human adipose tissue in obesity and following weight loss.

Gene Expression 59

Gene Expression Gene In-Vivo In-Vitro 59

Scienmag

JUNE 30, 2025

Importantly, the study’s findings emphasize that gene regulatory changes can underpin significant phenotypic innovation beyond protein-coding mutations.

Gene Expression 80

Gene Expression Gene Regulation In-Vivo 80