AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 2, 2024

Alzheimer’s disease is commonly associated with clumps and tangles of proteins building up in brain cells. A study led by researchers from the Stanford University School of Medicine returned to observations of large fat drops […]

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Protein Medicine Research Clinical Trials 156

Medical Xpress

DECEMBER 5, 2022

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

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XTalks

MARCH 31, 2023

BMS researchers on the mission will study the crystallization of an assortment of their biologics medicines in microgravity. By growing high quality crystal structures of protein-based therapeutics under microgravity, researchers can gain better insights into their complex structures and stability.

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Medical Xpress

MARCH 21, 2023

An international study led by the Molecular Physiology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) identifies new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer's disease.

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Protein Gene Life Science Research 98

Drug Discovery World

FEBRUARY 12, 2024

million grant to engineer microbial cell factories to produce membrane proteins which will support future drug screening and sustainable chemical production. The Engineering Biology Mission Award was given by UK Research and Innovation (UKRI). for drug discovery research appeared first on Drug Discovery World (DDW).

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Drug Discovery World

FEBRUARY 13, 2024

It goes on to show that NX-2127, a potent targeted protein degrader with differentiated activity against BTK and IKZF1/3, can overcome this resistance across a broad range of acquired mutations. The post Protein degrader overcomes resistance in B-cell malignancies appeared first on Drug Discovery World (DDW).

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Protein Medicine Scientist Research 52

Medical Xpress

NOVEMBER 8, 2022

Researchers at the University of Maryland School of Medicine's (UMSOM) Center for Precision Disease Modeling identified how a specific protein in SARS-CoV-2, the virus responsible for COVID-19, damages heart tissue. They then used a drug to reverse the toxic effects of that protein on the heart.

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Protein Medicine Drugs Research 98

Drug Discovery World

FEBRUARY 7, 2024

Professor Jonathan Blackburn, Chief Scientific Officer (CSO) of Sengenics, featured in a sponsored DDW Sitting Down With podcast to discuss the advantages of functional protein microarrays, challenges to overcome for biomarker discovery, Sengenics’ new i-Ome Discovery chip, and more. Sengenics can also help comb through all the data.

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Medical Xpress

MARCH 29, 2023

Sanford Burnham Prebys researchers have identified a group of proteins that could be the secret to cellular reprogramming, an emerging approach in regenerative medicine in which scientists transform cells to repair damaged or injured body tissues.

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Medicine Protein Scientist Research 98

XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. Human plasma, the clear, liquid portion of blood, is composed of water, electrolytes, nutrients and crucial proteins such as antibodies, clotting factors and albumin.

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Medicine Recombinant Antibody Protein Antibody 111

Pharmaceutical Technology

SEPTEMBER 14, 2022

API peptides and proteins-based drugs have gained much attention in the past decade. Discover the top API protein and peptide companies in contract marketing. Technologies in the delivery of peptides and proteins. They are promising therapeutics for the treatment of a variety of metabolic and oncological disorders.

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Drug Discovery World

MAY 4, 2023

Adaptyv Bio, a Swiss/US technology company that develops infrastructure and tools for protein designers to engineer better proteins, has built a protein engineering foundry that it says will “pave the way” for protein designers to develop new medicines, novel enzymes and sustainable materials.

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Engineer Protein Life Science Medicine 52

Scienmag

APRIL 27, 2021

Credit: UT Southwestern Medical Center DALLAS – April 27, 2021 – Researchers with the Peter O’Donnell Jr. Scientists from the departments of […].

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Protein Research Scientist Medicine 96

Scienmag

MARCH 4, 2022

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.

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Protein Gene Medicine Research 83

Medical Xpress

DECEMBER 21, 2022

A team at Canada's Lawson Health Research Institute has discovered unique patterns of blood plasma proteins in critically ill patients that may help develop a more personalized approach to treating severe COVID-19. Their work is published in the Journal of Cellular and Molecular Medicine.

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Protein Research Medicine Development 56

Pharma Mirror

OCTOBER 6, 2021

Limerick, Ireland: Irish SFI-funded research centre SSPC has announced a major collaboration with five of the world’s leading BioPharma companies that aims to reduce waste, maintain standards and minimise costs in pharmaceutical processes. Chromatography requires an antibody to bind to a protein A resin.

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Research Protein Antibody Manufacturing 130

Pharmaceutical Technology

JULY 7, 2022

But scientists have struggled to find effective treatments for many of these diseases since the dawn of modern medicine. A new frontier in cancer research. It is certainly a pivotal moment for the cell and gene industry, with the next decade of R&D and clinical trials expected to transform the future of medicine.

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Gene Therapy Gene Medicine Genetics 245

Medical Xpress

MARCH 28, 2023

The fast motor kinetics of prestin, a protein found in the inner ear, is essential for hearing high-frequency sounds, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.

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Protein Medicine Research 81

Medical Xpress

APRIL 5, 2023

A study by Indiana University School of Medicine researchers sheds new light on the development and treatment of a rare form of muscular dystrophy. The study's findings were recently published in Nature Communications.

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Protein Research Medicine Development 75

Drug Discovery World

JULY 24, 2023

The Defense Advanced Research Projects Agency (DARPA) has announced that Ginkgo Bioworks, which is building a platform for cell programming and biosecurity, has been awarded a four-year contract worth up to $18 million to reimagine how to manufacture complex therapeutic proteins.

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Scienmag

JUNE 10, 2022

PHILADELPHIA — A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

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Protein Medicine Drugs Research 83

Scienmag

JUNE 30, 2021

Credit: Copyright Joslin Diabetes Center Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center that will be published 30th June in Science Translational Medicine.

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Protein Medicine Research 85

Scienmag

JUNE 29, 2022

In a study of eye fluid from 38 patients, Johns Hopkins Medicine researchers say they have found that levels of a specific protein appears to help accurately predict whether people with the wet form of age-related macular degeneration may need lifelong, frequent eye injections to preserve vision or if they can be safely weaned off […].

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Protein Medicine Research 80

Scienmag

SEPTEMBER 11, 2020

Finding could lead to future treatments for hearing loss Credit: University of Maryland School of Medicine Researchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells. Some of […].

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Protein Development Research Medicine 61

Scienmag

DECEMBER 23, 2021

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

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Protein Scientist Research Medicine 92

Drug Discovery World

JANUARY 20, 2023

Precision medicine uses information about an individual’s genes, proteins, and environment to prevent, diagnose, and treat diseases, including cancer. Differences in DNA, RNA, and protein can be identified in individual tissue samples, and even in individual cells.

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Drug Discovery World

SEPTEMBER 25, 2023

IDT will stock and sell three additional research use only (RUO) and current good manufacturing practice (cGMP) CRISPR nucleases with unique performance characteristics, manufactured by Aldevron, to provide researchers with an accelerated path to the clinic.

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Drug Discovery World

APRIL 3, 2024

In the last few years, immunotherapies like immune checkpoint inhibitors, vaccines and cell and gene therapies have revolutionised the treatment of cancer, and targeted drugs like monoclonal antibodies (mAbs), poly-ADP ribose polymerase (PARP) inhibitors and targeted protein degraders are also playing an important role.

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Scienmag

JUNE 9, 2021

Researchers identified the protein responsible for cancer’s aggressiveness Credit: Dorothy Kozlowski/UGA Prostate cancer is the second most common cancer among men, according to the American Cancer Society. But new research from the University of Georgia has identified a protein that appears to prevent the […].

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Protein Research Medicine 95

Medical Xpress

MARCH 29, 2023

A team of researchers from Ohio University's Heritage College of Osteopathic Medicine has recently discovered a novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health.

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Protein Insulin Research Gene 69

Medical Xpress

NOVEMBER 10, 2022

Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The research, led by scientists from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, U.K.,

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Protein Scientist Medicine Research 75

Scienmag

MAY 14, 2021

Approach opens a new avenue to study the biology of acute leukemia and for the development of new drugs Credit: Grembecka / Cierpicki Labs The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases.

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Protein Development Research Gene 70

Drug Discovery World

MAY 18, 2023

Scientists in Japan have used a novel technique to identify a protein complex degraded by autophagy that has a possible role in liver cancer. p62 protein forms a membrane-less cytosolic organelle called p62 body and helps in the selective removal of toxic cellular waste through autophagy.

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Protein Scientist Medicine Regulation 52

Drug Discovery World

APRIL 11, 2024

Anyone involved in developing medicines from an early stage, knows that the road from idea to patients is full of unexpected trials and tribulations. MT: What drug discovery breakthrough has been most impactful to your research? MT: What advice would you offer someone looking to follow in your footsteps?

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Research Immune Response Antibody Medicine 59

Scienmag

OCTOBER 29, 2020

First study to show SARS-CoV-2 spike proteins disrupt the blood-brain barrier, potentially raising risk of neurological damage in COVID-19 patients Credit: Lewis Katz School of Medicine at Temple University (Philadelphia, PA) – Like a key, SARS-CoV-2 – the virus that causes coronavirus disease 2019 (COVID-19) – attaches to specific (..)

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Protein Research Medicine 75

Drug Discovery World

FEBRUARY 16, 2023

Challenges remain with current delivery approaches, and genetic medicines applications have been generally restricted to the liver and ex vivo settings. The post Start-up aims to advance transformative genetic medicines appeared first on Drug Discovery World (DDW).

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Genetics Medicine Gene Editing In-Vivo 52

Drug Discovery World

SEPTEMBER 4, 2023

In the third and final part of this series of articles focused on plant-based medicines, DDW’s Megan Thomas evaluates therapeutic breakthroughs using plant-based products in drug discovery. In this study, researchers discovered how EGCG breaks apart tangles of the protein tau, a ‘hallmark’ of Alzheimer’s disease.

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Medicine Protein Containment Drugs 59