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Amivantamab by Johnson & Johnson for Colorectal Cancer: Likelihood of Approval

Pharmaceutical Technology

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Amivantamab overview Amivantamab-vmjw (Rybrevant) is a low-fucose human immunoglobulin G1-based bispecific antibody developed using recombinant DNA technology.

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The DDW Podcast: 2022 in review 

Drug Discovery World

Recombinant DNA technology and its impact on modern drug discovery . Now is the time for the transformation of clinical trials . Sitting Down With . Catch up on the Sitting Down With podcast episodes released in 2022: . How to accelerate mouse model generation without reducing quality . Narrated Podcasts.

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Sanofi/GSK restart COVID-19 vaccine trials after tweaking formulation

pharmaphorum

In December interim phase 1/2 trial results showed the vaccine produced a lower immune response in older adults. The vaccine is based around an adjuvanted recombinant protein, which will be tested in a new phase 2 study to assess the response including in older adults.

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Leading innovators in gene splicing using nucleases for the pharmaceutical industry

Pharmaceutical Technology

Innovation S-curve for the pharmaceutical industry Gene splicing using nucleases is a key innovation area in the pharmaceutical industry Nucleases play a fundamental role in the field of recombinant DNA technology, or genetic engineering. Nucleases are enzymes that hydrolytically cleave the phosphodiester backbone of DNA.