Drug Discovery World

JULY 17, 2023

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

Bacteria 52

Bacteria Drugs Gene Immune Response 52

Drug Discovery World

NOVEMBER 4, 2022

New research has furthered our understanding of the immune-related factors that drive infection and disease, which will be necessary for an effective tuberculosis (TB) vaccine to be developed. infection in infants who became infected with the bacteria but did not progress to active TB. Most individuals infected with M.tb

Vaccination 52

Vaccination Vaccine Development Bacteria 52

Drug Discovery World

MAY 28, 2024

Researchers from The University of Queensland and the Queensland Children’s Hospital (QCH) have successfully tested the first-in-class drug in mice. A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient’s blood vessels.

Drugs 59

Drugs Immune Response Clinical Trials Clinical Trials 59

XTalks

JANUARY 20, 2021

Researchers at KU Leuven in Belgium have found a potential mechanism underlying irritable bowel syndrome (IBS) that involves activation of immune cells primed by past gastrointestinal infections. The research findings were published in the journal Nature. Related: Monitoring Patients with IBS or Kidney Failure?

Immune Response 52

Immune Response Research Allergies Protein 52

Drug Discovery World

JANUARY 12, 2024

This week has seen a number of significant discoveries by researchers in academic institutions, in some cases in partnership with industry, emphasising the important role universities play in early-stage drug discovery. News round-up for 8-12 January by DDW Digital Content Editor Diana Spencer.

Drugs 52

Drugs Immune Response Allergies Bacteria 52

Drug Discovery World

JANUARY 24, 2023

University of Queensland researchers have identified a pathway in cells that could be used to reprogramme the body’s immune system to fight back against both chronic inflammatory and infectious diseases. Coli bacteria from growing,” Dr Das Gupta said. “It

Scientist 52

Scientist Bacteria Clinical Trials Clinical Trials 52

Scienmag

NOVEMBER 17, 2020

New research published in Arthritis & Rheumatology suggests that immune responses to certain bacteria that cause periodontal disease may play a role in patients’ higher cardiovascular disease risk. Among 197 patients with rheumatoid arthritis, those with antibody responses to common […].

Immune Response 40

Immune Response Bacteria Antibody Research 40

Drug Discovery World

MARCH 17, 2023

The top stories: mRNA vaccine 100% effective against deadly bacteria For the first time, researchers have developed an mRNA vaccine that is 100% effective against a type of bacteria that is lethal to humans, paving the way for effective vaccination against antibiotic-resistant bacteria.

Bacteria 52

Bacteria Drugs Scientist Vaccination 52

XTalks

AUGUST 26, 2020

Macrophages are white blood cells that specialize in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In other words, when fighting bacteria, the macrophages are programmed to be pro-inflammatory. However, when they are programmed to be anti-inflammatory, they can help decrease inflammation.

Bacteria 105

Bacteria Immune Response Protein Medicine 105

The Pharma Data

NOVEMBER 12, 2020

12, 2020 — Lung cancer patients who harbor certain bacteria in the airways may have a poorer prognosis, a new study finds, adding to evidence that the body’s “microbiome” may play a role in cancer patients’ outlook. None of that proves the bacteria, themselves, were to blame, Segal said. THURSDAY, Nov.

Bacteria 52

Bacteria Immune Response Research Doctors 52

XTalks

JULY 28, 2021

Merck has scored US Food and Drug Administration (FDA) approval for its next-generation pneumonia vaccine Vaxneuvance that covers 15 different strains of the pneumococcal bacteria that causes the infection. Both next-gen shots offer enhanced protection against bacteria that can cause pneumonia, blood infections and meningitis.

FDA Approval 89

FDA Approval Vaccination Vaccine Immune Response 89

pharmaphorum

DECEMBER 4, 2020

Valneva has said it plans to accelerate research into its Lyme disease vaccine candidate VLA15, bringing forward a trial including children into the first quarter of 2021. OspA is one of the most dominant surface proteins expressed by the bacteria when present in the ticks that spread the disease.

Vaccination 117

Vaccination Vaccine Bacterium Protein 117

The Pharma Data

MARCH 13, 2022

That’s because the mutations that led to the variant’s emergence aren’t found in the regions of the virus that stimulates one type of cellular immune response, says an international research team from Johns Hopkins Medicine, in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) and ImmunoScape, a U.S.-Singapore

Immune Response 52

Immune Response Protein Medicine Genetics 52

Camargo

JULY 27, 2021

The technology of gene therapy is possible due to extensive DNA research and our resulting understanding of many diseases on the genetic level, and it encompasses several mechanisms such as introducing new genes (gene addition) and inactivating or replacing mutated genes (gene editing).

Gene Therapy 238

Gene Therapy Gene Gene Editing Genetics 238

Pharmaceutical Technology

FEBRUARY 15, 2023

The key component in all vaccines is one or more active ingredients made from viruses or bacteria, also called antigens, which generates an immune response. To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.

Vaccination 130

Vaccination Vaccine Containment Immune Response 130

The Pharma Data

JULY 18, 2021

Clinical Data Supporting Approval Demonstrated Non-Inferior Immune Responses for the Serotypes Shared with PCV13 (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F). VAXNEUVANCE Elicited Superior Immune Responses for Serotypes 3, 22F and 33F Compared to PCV13, Which Are Major Causes of Disease.

Immune Response 52

Immune Response Vaccination Vaccine FDA Approval 52

Olympian Clinical Research

NOVEMBER 16, 2022

According to the American Academy of Dermatology , scientists believe that when a hair follicle becomes clogged with keratin, bacteria breed within it. When a hair follicle has more keratin and bacteria than it can hold, it bursts, causing the cyst-like breakout associated with HS. Clinical Research on Hidradenitis Suppurativa.

Clinical Research 52

Clinical Research Bacteria Dermatology Immune Response 52

XTalks

JULY 21, 2022

Some research shows that, when consumed, probiotics can help maintain a balanced gut microbiome, which supports gastrointestinal health and function. They can also help your body maintain a healthy community of microorganisms, produce substances that have desirable effects and influence your body’s immune response. percent.

Containment 52

Containment Branding Bacteria Immune Response 52

The Pharma Data

JUNE 30, 2021

For their remarkable scientific contributions, doctoral student Julia Klaus, Zurich University VetSuisse Faculty, and Dr Yasmin Parr from the MRC-University of Glasgow, Centre for Virus Research, have received the 2021 ABCD Young Scientist Award. To foster young talent development in the feline health research community. References.

Scientist 52

Scientist Immune Response Antibody Development 52

The Pharma Data

MARCH 23, 2022

Researchers at Johns Hopkins Children’s Center report evidence from lab experiments that a chemical derived from a compound found abundantly in broccoli and other cruciferous plants may offer a potentially new and potent weapon against the viruses that cause COVID-19 and the common cold. alone each year. decrease).

Immune Response 52

Immune Response In-Vitro Research Scientist 52

pharmaphorum

APRIL 26, 2022

PubMed cites 1,822 pieces of research relating to the microbiome in 2011, which grew to 25,153 published in 2021. As more research has been conducted, closer and unexpected links have been found between the microbiome of the gut, as one example, and other areas of the body, such as brain health and the immune system.

Containment 113

Containment Development Production Immune Response 113

The Pharma Data

DECEMBER 13, 2020

SYNB1891 is an investigational drug for the intra-tumoral treatment of solid tumors and lymphoma, composed of an engineered Synthetic Biotic designed to activate the STING pathway in the tumor microenvironment in order to upregulate the patient’s immune response. Synlogic’s President and Chief Executive Officer.

Immune Response 40

Immune Response Engineer Clinical Trials Clinical Trials 40

Drug Discovery World

MARCH 14, 2023

For the first time, researchers have developed an mRNA vaccine that is 100% effective against a type of bacteria that is lethal to humans, paving the way for effective vaccination against antibiotic-resistant bacteria. However, until now scientists believed that mRNA vaccines against bacteria were biologically undoable.

Bacteria 59

Bacteria Vaccination Vaccine Protein 59

The Pharma Data

OCTOBER 19, 2020

Immune responses following vaccination with PNEUMOVAX 23 (month 13) were comparable in both vaccination groups for the 15 serotypes in V114. Results from both studies are based on opsonophagocytic activity (OPA) responses – a measure of vaccine-induced functional antibodies. among adults 65 years of age or older.

Vaccination 52

Vaccination Vaccine Immune Response Containment 52

Drug Discovery World

MAY 6, 2024

In a boost to cancer research for both regions, in November 2023, Cancer Research UK and the KWF Dutch Cancer Society (KWF) announced a multi-project strategic partnership. Beyond this specific plan, France has a strong policy to support innovation with research tax credits and specific programmes.

Drugs 59

Drugs Life Science Gene Editing Gene 59

XTalks

NOVEMBER 28, 2022

It may be caused by the immune system being triggered by a virus or bacteria that results in an atypical immune response, or genetics play a role in disease development as it is more common in people whose immediate family members have Crohn’s disease.

Trials 52

Trials Immune Response Bacteria Genetics 52

Pfizer

FEBRUARY 16, 2023

GCP is the international ethical and scientific quality standard for clinical trials that all clinical researchers need to follow. OspA is a surface protein expressed by the bacteria when present in a tick. VLA15 has demonstrated a strong immune response and satisfactory safety profile in pre-clinical and clinical studies so far.

Clinical Trials 76

Clinical Trials Clinical Trials Vaccination Vaccine 76

The Pharma Data

DECEMBER 31, 2020

But painstaking work by Australian researchers has revealed that people infected with the SARS-CoV-2 virus have immune memory to protect against reinfection for at least eight months. “Because of the biology of the persistence of these memory cells, it anticipates that we will have rather durable immunity,” said Dr. .

Vaccination 52

Vaccination Vaccine Antibody Immune Response 52

The Pharma Data

DECEMBER 31, 2020

Researchers at Stanford Medicine found that COVID-19 antibodies preferentially target different parts of the SARS-CoV-2 virus in mild COVID-19 cases than they do in severe cases. Antibody responses are not likely to be the sole determinant of someone’s outcome,” said Scott Boyd, associate professor of pathology at Stanford.

Antibody 52

Antibody Research Bacteria Genetics 52

XTalks

DECEMBER 17, 2021

And in healthcare and health research, trends towards increased digitization continued, including remote monitoring in clinical trials, use of wearable technologies and AI-based approaches to data collection, management and analysis. The results are promising and Moderna is set to go ahead with its planned Phase II trial for the vaccine.

Life Science 98

Life Science Vaccination Vaccine Trials 98

Drug Discovery World

FEBRUARY 15, 2023

Cancer is a complex heterogenous multistep disease characterised by uncontrolled cell proliferation combined with a dysregulated immune response. A healthy immune system is naturally primed to eliminate malignant and abnormal cells through a synchronised and dynamic interplay between adaptive and innate immunity.

Research 52

Research In-Vitro In-Vivo Development 52

The Pharma Data

JANUARY 21, 2021

Researchers at Washington University School of Medicine in St. The research was published in the journal JCI Insight. The research team evaluated 97 patients with COVID-19 at Barnes-Jewish Hospital. How the Immune System Drives Brain Aging. The research was conducted in mice and humans.

Research 52

Research DNA Hormones Vaccination 52

Drug Discovery World

JANUARY 23, 2023

Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. A course of antibiotics at two weeks of age, however, permanently changed the composition of bacteria in their microbiomes. Morriss III Distinguished Professor of Neurology.

Bacteria 52

Bacteria Genetics Immune Response Protein 52

XTalks

AUGUST 18, 2021

“I think that the pandemic has drawn much attention to some of the threats that have been posed by emerging infections,” says Brian Murphy, MD, MPH, FIDSA, Vice President of the Medical Department for global contract research organization (CRO) Medpace. And again, reminded us all of the importance of investing in public health.”.

Development 105

Development Bacteria Drugs Vaccination 105

The Pharma Data

JUNE 18, 2021

Senior Vice President and Head of Vaccine Research & Development, Pfizer. With a single injection, PREVNAR 20 provides adults with strong and meaningful protection against serotypes responsible for the majority of circulating pneumococcal disease around the world.”. Jansen, Ph.D., Global President of Pfizer Vaccines. “We

Vaccination 52

Vaccination Vaccine FDA Approval Containment 52

The Pharma Data

DECEMBER 15, 2020

However, if the immune system malfunctions, it can attack healthy cells, tissues and organs. Researchers are aware of more than 80 diseases that occur when the immune system attacks the body’s own organs, tissues and cells. The human monoclonal antibody targets specific immune plasma cells. New Immune System Cell.

Clinical Trials 52

Clinical Trials Clinical Trials Antibody Trials 52

Pharmaceutical Technology

MARCH 24, 2023

TB is caused by the bacillus Mycobacterium tuberculosis and is transmitted when infected individuals expel bacteria into the air (e.g., Researchers expect TB to soon return to its pre-2020 position as the deadliest infectious disease globally. The ID93 vaccine is being developed by the Infectious Disease Research Institute (IDRI).

Vaccination 162

Vaccination Vaccine Clinical Trials Clinical Trials 162