Optimising AAV capsid purification through improved analytics
Drug Discovery World
FEBRUARY 8, 2023
In AAV therapeutics, empty capsids are those that are not packaged with the therapeutic DNA. First, empty capsids may have the potential to induce an elevated immune response to high concentrations of viral particles. Robustness: to be able to tolerate matrix effects (type of buffer, residual contaminants, ionic strength, etc.)
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