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Clinical trial will test novel inhaled TB vaccine

Drug Discovery World

Professor Helen McShane, Chief Investigator, TB Vaccine Trials Jenner Institute, University of Oxford, said: “TB kills more people than any other infectious disease and we urgently need better vaccines. The post Clinical trial will test novel inhaled TB vaccine appeared first on Drug Discovery World (DDW).

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China’s NMPA accepts IND for SinoMab BioScience’s SM17 to treat asthma

Pharmaceutical Technology

The Center for Drug Evaluation (CDE) of China’s National Medical Products Administration (NMPA) has accepted an investigational new drug application (IND) for SinoMab BioScience’s SM17 to treat asthma. It can suppress Th2 immune responses by binding to IL-17RB on Type 2 innate lymphoid cells (ILC2s).

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Mix-and-match trial finds additional dose of COVID-19 vaccine safe, immunogenic

Scienmag

WHAT: In adults who had previously received a full regimen of any of three COVID-19 vaccines granted Emergency Use Authorization (EUA) or approved by the Food and Drug Administration (FDA), an additional booster dose of any of these vaccines was safe and prompted an immune response, according to preliminary clinical trial results reported in The […]. (..)

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Altimmune ditches nasal COVID vaccine on weak trial data

pharmaphorum

Just a few months after starting clinical trials of its nasal spray vaccine for COVID-19, US biotech Altimmune is abandoning the project, saying that it generated weaker than expected immune responses in a phase 1 trial. . The post Altimmune ditches nasal COVID vaccine on weak trial data appeared first on.

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“Game-changing” personalised cancer vaccine enters UK clinical trials   

Drug Discovery World

A clinical trial of a personalised mRNA cancer vaccine for melanoma patients has been launched in the UK. The post “Game-changing” personalised cancer vaccine enters UK clinical trials appeared first on Drug Discovery World (DDW). in the combination arm and 62.2%

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Phase I trial of next-generation srRNA rabies vaccine

Drug Discovery World

Replicate Bioscience has dosed the first participant in a Phase I trial of its RBI-4000 vaccine for the prevention of rabies. Replicate’s srRNA technology offers the potential for more robust and durable immune responses, and improved tolerability at lower doses than existing mRNA approaches,” said Zelanna Goldberg, CMO of Replicate. “In

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EC grants approval for Sanofi-GSK’s Covid-19 booster

Pharmaceutical Technology

The vaccine elicited a robust immune response against several variants in registrational trials conducted when the Omicron variant of the virus was dominant. These trials comprised the Phase III VAT08 Stage 2 trial analysing initial efficacy and two other immunogenicity trials.