Pharmaceutical Technology

OCTOBER 6, 2022

BioLink Life Sciences has received a contract worth $750,000 from the US Biomedical Advanced Research and Development Authority (BARDA) to develop Ramatroban for treating Covid-19 pneumonia patients in the hospital setting. The trial will also lay the ground for additional trials for acute and long Covid in the US.

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Development Life Science Immune Response Trials 162

The Pharma Data

NOVEMBER 10, 2020

Weiner, chairman of the scientific advisory board of Tiziana Life Sciences, commented: “We understand that this will be the first-ever study with ‘take-home’ capsules of any mAb for immunotherapies for human diseases. Tiziana Life Sciences January 9, 2020 Press Release ( [link] ). Billion by 2025. and Europe.

Life Science 40

Life Science Clinical Trials Clinical Trials Trials 40

BioTech 365

OCTOBER 22, 2020

-Proof-of-concept achieved for VY-UC to engineer donor cells without the complexities of gene-editing -Novel platform abrogates cellular immune response and obviates the need for immunosuppressive drugs TAMPA, Fla. & an immuno-centric discovery life science company with a … Continue reading →

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Gene Editing Immune Response Life Science Engineer 52

XTalks

AUGUST 8, 2022

Medicxi is a prominent international life sciences investment firm that invested in over 60 portfolio companies such as Versanis Bio, Rivus Pharmaceuticals, Capella Bioscience and more. One of Medicxi’s portfolio companies called MiroBio is set to be acquired by Gilead Sciences for approximately $405 million in cash.

Immune Response 98

Immune Response Antibody Life Science Engineer 98

Drug Discovery World

MARCH 30, 2023

Likang Life Sciences has been granted implied approval by China’s National Medical Products Administration (NMPA) for the clinical trial of its innovative personalised neoantigen-targeted vaccine LK101 Injection for advanced solid tumours.

Regulation 52

Regulation Vaccination Vaccine Trials 52

The Pharma Data

JANUARY 3, 2021

. This trial is the first to evaluate nasally administered Foralumab to improve the immune system’s fight against coronaviruses. Patient reported outcome to assess clinical responses related to COVID-19 symptoms, as per the FDA guidelines, will also be collected. About Tiziana Life Sciences.

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Life Science Clinical Trials Clinical Trials Antibody 40

XTalks

FEBRUARY 19, 2024

The study compared the immune responses evoked by Moderna’s mRNA vaccine to those generated by a previous vaccine candidate, namely, the MF59-adjuvanted glycoprotein B (gB) proten subunit vaccine (gB/MF59) developed by Sanofi. Paduano Professor in Pediatrics at Weill Cornell Medicine, in a news release.

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Vaccination Vaccine Trials Clinical Trials 59

pharmaphorum

JULY 26, 2021

. “Being able to distinguish the IgM from the IgG class of antibody response will also provide potentially useful information about the stage of a person’s immune response, and its likely persistence over time,” he added. The post Rapid COVID immune status test launched in UK, Ireland appeared first on.

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Antibody Immune Response Vaccination Vaccine 136

Drug Discovery World

MAY 6, 2024

Thanks to a prestigious academic legacy, Europe has long been a dominant region for life sciences. Europe is traditionally a life sciences powerhouse, with a strong tradition in pharmaceutical discovery. The oldest, still active pharmaceutical company worldwide, Merck, started life in 1668 in Darmstadt, Germany.

Drugs 59

Drugs Life Science Gene Editing Gene 59

pharmaphorum

MARCH 4, 2021

UK chancellor Rishi Sunak has announced a budget loaded with initiatives designed to kick-start the UK’s economy as it recovers from the coronavirus pandemic, with vaccine development, pharma and life sciences playing a key role. A scheme providing £500 payments to people self-isolating has been extended in England until the summer.

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Vaccination Vaccine Development Life Science 103

XTalks

OCTOBER 12, 2021

The vaccine was tested in rats and showed strong, immediate and long-lasting immune responses to confer protection against the disease. is an autoantigen, which means it is an endogenous antigen that triggers an immune response in the body. as a potential trigger for rheumatoid arthritis.

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Vaccination Vaccine Research Immune Response 105

pharmaphorum

JULY 18, 2022

It then elicits an immune response against that spike protein. You have a response with immunoglobulins type G (antibodies) and robust cellular response with both CD4 and CD8 T-cells being activated,” Morgon states. We get a higher immune response with the inhaled compared to the injectable,” Morgon relays.

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Vaccination Vaccine Development Immune Response 126

Drug Discovery World

JANUARY 31, 2023

This includes the advancement of the company’s lead asset, GRWD5769, into a Phase I/II clinical trial in the first half of 2023. Grey Wolf Therapeutics’ strategy is centred on generating entirely novel immune responses against tumours, thereby overcoming key resistance mechanisms to current immuno-oncology therapy such as poor tumour recognition (..)

Immune Response 52

Immune Response Clinical Trials Clinical Trials Life Science 52

XTalks

NOVEMBER 6, 2020

Symvivo’s bacTRL Gene Therapy Platform is designed and optimized to address limitations associated with typical vaccines, including the inability to accommodate large or multiple genes, lack of specificity to targeted tissue and poor control over immune response, says the company.

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Clinical Trials Clinical Trials Vaccination Vaccine 75

Pharmaceutical Technology

NOVEMBER 22, 2022

The mission was first put forward during the UK’s G7 Presidency of June 2021, with support from representatives of the life sciences industry. billion towards the “pandemic-busting plan”, which involves the investigation of rapid response vaccine technologies. The UK Government is behind this effort.

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Manufacturing Vaccination Vaccine RNA 130

XTalks

JUNE 24, 2022

In a subset of 230 children six months through 23 months of age, the immune response after receiving a two-dose primary series of 25 micrograms of the Moderna mRNA vaccine was comparable to the immune response of adults (18 to 25 years of age who received two higher doses of the vaccine in a previous study).

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Vaccination Vaccine Immune Response Trials 98

XTalks

JANUARY 20, 2021

While diseases like celiac are associated with inappropriate activation of the immune system triggered by food antigens, this is not the case in IBS. In a normal, healthy intestine, foods do not trigger immune responses and so in a patient with IBS, something else must activate the response. Mouse and Human Studies.

Immune Response 52

Immune Response Research Allergies Protein 52

pharmaphorum

APRIL 28, 2021

“Text mining was also able to highlight new insights into the mechanisms of pancreatic cancer’s immune evasion, which refers to cancer cells’ ability to evade an immune response” . Ferroptosis and immune evasion are highly relevant to pancreatic cancer and remain areas where further research is required.

Immune Response 104

Immune Response Life Science Genome Genomics 104

XTalks

JULY 26, 2023

XTALKS WEBINAR: Cancer Immunotherapy: Exploring Imaging as a Catalyst to Immune Response Prediction Live and On-Demand: Wednesday, September 27, 2023 , at 2pm EDT (11am PDT) Register for this free webinar to discover the present and transformative impact of predictive biomarkers on immunotherapy response, the role of cytotoxic T cells expressing CD8 (..)

FDA Approval 98

FDA Approval Immune Response Drugs Trials 98

XTalks

MAY 17, 2024

The vaccine used a ‘mosaic’ approach, designed to trigger immune responses against a wide variety of HIV strains globally. Their ongoing Phase I trial aims to leverage Moderna’s mRNA platform to produce HIV vaccine antigens, hoping to induce a broad and robust immune response.

Vaccination 52

Vaccination Vaccine Research Immune Response 52

XTalks

AUGUST 14, 2023

XTALKS WEBINAR: Cancer Immunotherapy: Exploring Imaging as a Catalyst to Immune Response Prediction Live and On-Demand: Wednesday, September 27, 2023, at 2pm EDT (11am PDT) Register for this free webinar to discover the present and transformative impact of predictive biomarkers on immunotherapy response.

FDA Approval 97

FDA Approval Antibody Immune Response Drugs 97

XTalks

NOVEMBER 20, 2020

Traditional antibody tests for uncovering past infections involve detection of antigen-specific antibodies produced during an immune response against a pathogen. The Adaptive Immune System and TCRs. These common TCRs are the reason why the same immune responses are generated in different people.

Antibody 98

Antibody Immune Response Protein In-Vitro 98

XTalks

NOVEMBER 30, 2023

Preclinical data demonstrated that HB-500 was well-tolerated, eliciting robust, high-quality and enduring immune responses, including antigen-specific T cells and antibodies, in non-human primates. In November 2023, Hookipa Pharma Inc., Notably, it significantly reduced viral load and clinical illness compared to a placebo.

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FDA Approval Gene Therapy Clinical Trials Clinical Trials 111

XTalks

JULY 28, 2021

While Merck’s previous shot, Pneumovax 23, defends against 23 serotypes and has been on the market for almost four decades, the immune responses it generates are not as durable as Prevnar 13. This is why Pfizer’s Prevnar 13 has dominated the pneumonia vaccine space for more than a decade.

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FDA Approval Vaccination Vaccine Immune Response 89

XTalks

APRIL 26, 2021

Moreover, a very strong immune response is needed to fend off the disease. The vaccine is protein-based and contains an adjuvant (MM), a component that helps generate a stronger immune response, that was developed by Novavax. Malaria Vaccine Phase II Trial. At six months, 29.5

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Vaccination Vaccine Immune Response Trials 105

XTalks

DECEMBER 14, 2021

Moderna revealed the first interim results from a small, Phase I study of its mRNA-based influenza vaccine, which showed that the vaccine had no significant safety concerns and elicited immune responses against four strains of the influenza virus. There were no significant safety findings reported through day 29. Mixed Results.

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Vaccination Vaccine Immune Response Antibody 98

pharmaphorum

JULY 20, 2021

According to some studies, beta may be the most likely to evade immune responses stimulated by the currently available shots as well as some antibody drugs for SARS-CoV-2, and is also thought to be more transmissible. 1.351) variant first identified in South Africa.

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Vaccination Vaccine Protein Immune Response 98

XTalks

DECEMBER 29, 2023

Classified as a bispecific T-cell engager (BiTE molecule), tarlatamab consists of two essential parts: one binds to T-cells, vital in immune response, and the other targets cancer cells. Tarlatamab differs from conventional chemotherapy as it’s an immunotherapy designed to help immune cells detect, attach to and fight cancer cells.

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Clinical Trials Clinical Trials FDA Approval Trials 119

XTalks

JUNE 15, 2022

protein that triggers the immune system to generate antibodies against the virus. Adjuvants can help boost the effectiveness of a vaccine and elicit a stronger immune response. Compared to adults, immune responses were approximately two- to three-fold higher in adolescents. The vaccine is given in two doses.

Vaccination 59

Vaccination Vaccine Immune Response Protein 59

Pharmaceutical Technology

JULY 22, 2022

Peter Hotez’s tweet on PAI Life Sciences’ phase 1 trial of its snail fever vaccine. The phase 1 clinical trial will evaluate the safety and immune response of the vaccine in healthy individuals at the Kaiser Permanente Washington Health Research Institute in Seattle, the article detailed. Retweets: 113.

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Vaccination Vaccine Life Science Immune Response 130

Drug Discovery World

FEBRUARY 28, 2024

Dr Nigel Blackburn, Director of Cancer Research UK’s Centre for Drug Development, says: “What’s interesting about IgE is its involvement in our body’s defence against parasites and the particularly powerful immune response it elicits.

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Development Research Drugs Antibody 64

Pharmaceutical Technology

APRIL 18, 2023

A piece of an HIV protein, an epitope from an HIV protein, or a mixture of several HIV proteins or fragments of them can all act as the antigenic polypeptide and produce an immune response. These can serve as an important component of a vaccine.

Protein 147

Protein Vaccination Vaccine Production 147

XTalks

AUGUST 26, 2020

The anti-inflammatory macrophages help in preventing an immune response from becoming dangerous, as seen with patients with autoimmune disease. This helps to ensure that inflammation naturally subsides after the initial immune response and promotes tissue repair.

Bacteria 105

Bacteria Immune Response Protein Medicine 105

pharmaphorum

DECEMBER 15, 2020

On the back of phase 1b data the Copenhagen-based biotech said it had brought in new investors Sanofi Ventures, Adjuvant Capital and Industrifonden along with existing investors Novo Holdings, REPAIR Impact, Sunstone Life Science Ventures and LF Investment. The post Minervax raises €47.4m

Bacteria 52

Bacteria Vaccination Vaccine Immune Response 52

XTalks

SEPTEMBER 16, 2021

The federal health regulator maintains that boosters of Pfizer’s vaccine may not be needed, but in documents prepared for outside advisors, FDA scientists acknowledged yesterday that a third dose can heighten immune responses.

Vaccination 52

Vaccination Vaccine Immune Response Clinical Trials 52

XTalks

NOVEMBER 10, 2020

Interim results of the trial show that all participants developed an antibody response after two doses of the COVID-19 adjuvanted vaccine candidate. Adjuvants are used to help stimulate stronger vaccine immune responses. These are very promising results. Plant-Based Vaccine Technology.

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Vaccination Vaccine Trials Immune Response 52

pharmaphorum

MARCH 23, 2021

In the case of AU-011, the VLPs are conjugated to an infrared dye called IRDye 700DX that when exposed to a laser causes direct damage to malignant cells and activates an immune response to the tumour, without damaging the healthy structures in the eye.

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Development Drugs Immune Response Life Science 63