Pharma Times

DECEMBER 20, 2023

Researchers from Johns Hopkins University School of Medicine have revealed new findings about a key pathological protein associated with Parkinson’s disease (PD), which could lead to new treatments. However, its relation to dopaminergic neuron death is unclear.

Protein 95

Protein Medicine Engineer Genetics 95

Pharmaceutical Technology

MARCH 27, 2023

Regenerative medicines in early-stage development (preclinical, discovery, or investigational new drug [IND]/ clinical trial application [CTA] filed status) have seen a change in drug targets compared to therapies in late-stage development (Phase II to pre-registration stage).

Medicine 246

Medicine Gene Therapy Gene Dermatology 246

Bio Pharma Dive

MAY 19, 2023

The biotech, best known for its vaccine research, said its clinical trial is the first to report results of a messenger RNA therapeutic designed for intracellular protein replacement.

RNA 294

RNA Medicine Clinical Trials Clinical Trials 294

Bio Pharma Dive

MAY 7, 2024

The company is using what it claims is the largest database of viral protein structures to unearth medicines for a range of diseases, said CEO and Flagship origination partner Lovisa Afzelius.

Protein 161

Protein Medicine Drugs 161

Pharmaceutical Technology

DECEMBER 23, 2022

Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines. The post Lilly and ProQR to expand genetic medicine development agreement appeared first on Pharmaceutical Technology.

Genetics 328

Genetics Medicine Development Gene Therapy 328

Bio Pharma Dive

MARCH 11, 2024

Sosei Heptares could receive more than 700 million euros in a deal to develop medicines aimed at the protein GPR52, an emerging drug target in multiple neurological diseases.

Drugs 278

Drugs Protein Medicine Development 278

Drug Discovery World

APRIL 17, 2024

Arvinas’ AR-V7-targeting PROTAC protein degrader is designed to target both AR-V7 and full-length AR. We are thrilled to partner with an organisation that shares our dedication to delivering transformative medicines to patients with significant unmet need,” said John Houston, Chairperson, President and Chief Executive Officer of Arvinas. “We

Protein 52

Protein Licensing Licensing Sales 52

Medical Xpress

FEBRUARY 16, 2023

An adenovirus serotype 26 respiratory syncytial virus (RSV) vector encoding a prefusion F (preF) protein (Ad26.RSV.preF) RSV.preF) in combination with RSV preF protein is immunogenic and prevents RSV-mediated lower respiratory tract disease in older adults, according to a study published in the Feb.

Protein 96

Protein Vaccination Vaccine Medicine 96

XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. Human plasma, the clear, liquid portion of blood, is composed of water, electrolytes, nutrients and crucial proteins such as antibodies, clotting factors and albumin.

Medicine 111

Medicine Recombinant Antibody Protein Antibody 111

Drug Discovery World

FEBRUARY 13, 2024

It goes on to show that NX-2127, a potent targeted protein degrader with differentiated activity against BTK and IKZF1/3, can overcome this resistance across a broad range of acquired mutations. The post Protein degrader overcomes resistance in B-cell malignancies appeared first on Drug Discovery World (DDW).

Protein 52

Protein Medicine Scientist Research 52

Medical Xpress

NOVEMBER 8, 2022

Researchers at the University of Maryland School of Medicine's (UMSOM) Center for Precision Disease Modeling identified how a specific protein in SARS-CoV-2, the virus responsible for COVID-19, damages heart tissue. They then used a drug to reverse the toxic effects of that protein on the heart.

Protein 98

Protein Medicine Drugs Research 98

Bio Pharma Dive

OCTOBER 24, 2023

The startup is taking aim at an inflammation-linked protein known as TSLP, which is the target of an approved asthma medicine.

Protein 306

Protein Medicine Drugs 306

Scienmag

NOVEMBER 22, 2021

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact.

Protein 90

Protein Scientist Genetics Medicine 90

Pharmaceutical Technology

SEPTEMBER 14, 2022

API peptides and proteins-based drugs have gained much attention in the past decade. Discover the top API protein and peptide companies in contract marketing. Technologies in the delivery of peptides and proteins. They are promising therapeutics for the treatment of a variety of metabolic and oncological disorders.

Protein 130

Protein Marketing Manufacturing Reagent 130

Drug Discovery World

MAY 4, 2023

Adaptyv Bio, a Swiss/US technology company that develops infrastructure and tools for protein designers to engineer better proteins, has built a protein engineering foundry that it says will “pave the way” for protein designers to develop new medicines, novel enzymes and sustainable materials.

Engineer 52

Engineer Protein Life Science Medicine 52

Bio Pharma Dive

MARCH 7, 2023

Rapport Therapeutics aims to find new so-called receptor-associated proteins that could serve as targets for neurological disease medicines. Its most advanced drug is already in early-stage human testing.

Drugs 362

Drugs Protein Medicine 362

Drug Discovery World

FEBRUARY 7, 2024

Professor Jonathan Blackburn, Chief Scientific Officer (CSO) of Sengenics, featured in a sponsored DDW Sitting Down With podcast to discuss the advantages of functional protein microarrays, challenges to overcome for biomarker discovery, Sengenics’ new i-Ome Discovery chip, and more. Sengenics can also help comb through all the data.

Medicine 59

Medicine Protein FDA Approval DNA 59

Bio Pharma Dive

FEBRUARY 15, 2024

Armed with $94 million in funding, the biotech is marrying antibody-drug conjugates with protein degraders to create a new kind of cancer medicine.

Protein 189

Protein Antibody Medicine Drugs 189

Medical Xpress

MARCH 28, 2023

The fast motor kinetics of prestin, a protein found in the inner ear, is essential for hearing high-frequency sounds, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.

Protein 81

Protein Medicine Research 81

Scienmag

JULY 15, 2021

New artificial intelligence software can compute protein structures in 10 minutes Credit: Ian Haydon, UW Medicine Institute for Protein Design Scientists have waited months for access to highly accurate protein structure prediction since DeepMind presented remarkable progress in this area at the 2020 Critical Assessment of Structure Prediction, or (..)

Protein 98

Protein Scientist Medicine Engineer 98

Pharmaceutical Technology

APRIL 27, 2023

Orbital will use the new funding to increase the application of RNA-based medicines for use in the fields of new vaccines, immunomodulation and protein replacement. New investors included the Redmile Group, the Abu Dhabi Growth Fund (ADG), Exor, Invus, Moore Strategic Ventures, the iGlobe Platinum Fund Group and Casdin Capital.

RNA 130

RNA Medicine Gene Therapy Gene 130

Medical Xpress

MARCH 21, 2023

An international study led by the Molecular Physiology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) identifies new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer's disease.

Protein 98

Protein Gene Life Science Research 98

Bio Pharma Dive

AUGUST 28, 2023

GPCRs, a ubiquitous family of proteins that are prime drug targets, have drawn the interest of companies like Structure Therapeutics, Septerna and now Superluminal Medicines.

Drugs 246

Drugs Protein Medicine 246

Pharmaceutical Technology

JUNE 20, 2023

Developed using pharmaceutical company GSK’s pandemic adjuvant, the vaccine targets the receptor-binding domain of the SARS-CoV-2 spike protein. The vaccine is based on recombinant protein vaccine technology and is suitable for storage between 2°C and 8°C. “We

Vaccination 363

Vaccination Vaccine Protein Clinical Trials 363

Scienmag

MARCH 4, 2022

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.

Protein 83

Protein Gene Medicine Research 83

Pharmaceutical Technology

APRIL 13, 2023

Clinical-stage biopharmaceutical firm Alentis Therapeutics has raised $105m in a Series C financing round for advancing transformational medicines targeting the CLAUDIN-1 protein.

Medicine 130

Medicine Development Antibody Engineer 130

Pharmaceutical Technology

JULY 7, 2022

But scientists have struggled to find effective treatments for many of these diseases since the dawn of modern medicine. Often referred to as a type of gene-modified cell therapy, CAR-T cell therapies involve genetically modifying a patient’s own T cells to produce a protein that enables them to identify and kill cancer cells.

Gene Therapy 245

Gene Therapy Gene Medicine Genetics 245

Bio Pharma Dive

OCTOBER 20, 2022

The deal gives AbbVie an experimental medicine for idiopathic pulmonary fibrosis, as well as a platform for designing antibody drugs that can target proteins known as GPCRs.

Protein 326

Protein Antibody Medicine Drugs 326

Drug Discovery World

JULY 24, 2023

The Defense Advanced Research Projects Agency (DARPA) has announced that Ginkgo Bioworks, which is building a platform for cell programming and biosecurity, has been awarded a four-year contract worth up to $18 million to reimagine how to manufacture complex therapeutic proteins.

Protein 52

Protein Manufacturing Gene Sequencing Production 52

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 2, 2024

Alzheimer’s disease is commonly associated with clumps and tangles of proteins building up in brain cells. A study led by researchers from the Stanford University School of Medicine returned to observations of large fat drops […]

Protein 161

Protein Medicine Research Clinical Trials 161

Medical Xpress

MARCH 29, 2023

Sanford Burnham Prebys researchers have identified a group of proteins that could be the secret to cellular reprogramming, an emerging approach in regenerative medicine in which scientists transform cells to repair damaged or injured body tissues.

Medicine 98

Medicine Protein Scientist Research 98

Scienmag

JANUARY 6, 2021

Proteins engineered to form honeycomb structures can block uptake of receptors from the surface of cells Credit: Ian Haydon, UW Medicine Institute for Protein Design A new class of protein material that interacts with living cells without being absorbed by them can influence cell signaling, a new study shows.

Protein 84

Protein Engineer Medicine 84

Medical Xpress

DECEMBER 5, 2022

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

Protein 75

Protein Genetic Engineering Research Engineer 75

Drug Discovery World

JANUARY 25, 2024

US company Vaxxinity and the University of Central Florida (UCF) have announced plans to work together to advance space medicine research. The post Immunotherapy partnership advances space medicine research appeared first on Drug Discovery World (DDW).

Medicine 52

Medicine Research In-Vivo In-Vitro 52

Bio Pharma Dive

JANUARY 29, 2024

A successor medicine to Sarepta's Exondys 51 appeared better at boosting dystrophin protein production, but was associated with electrolyte imbalances.

Protein 152

Protein Medicine Production 152

Bio Pharma Dive

APRIL 5, 2023

Public records and job postings show Resonance Medicine, which has ties to several high-profile venture capital firms, aims to reprogram protein-cutting enzymes to treat disease.

Protein 258

Protein Medicine 258

Scienmag

JUNE 30, 2021

Credit: Copyright Joslin Diabetes Center Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center that will be published 30th June in Science Translational Medicine.

Protein 85

Protein Medicine Research 85