Rethinking Clinical Trials

OCTOBER 13, 2022

There are some limitations and remaining questions from the trial: The trial did not include weekend and nighttime surgeries, so one remaining question is are handovers harmful during off-hours when fatigue and stress may play a bigger role? What instructions or guidance did you provide for the handover? Discussion Themes.

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Intouch Solutions

JUNE 27, 2023

Low Engagement Sessions and Rate replaces Bounces and Bounce Rate – Inverse of engaged session rate; users who did not meet the criteria listed for that metric. Based on this new metric and way of reporting, it is vital to partner with a tagging solutions expert to successfully tag the site that follows the GA4 event structure model.

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Marketing Branding Development 98

Rethinking Clinical Trials

JULY 27, 2022

– Before anyone was enrolled, which arm did you think would enroll the fastest? We did not see as much diversity in this decentralized trial. There was some evidence of increased acute care needs (urgent care, emergency room visit) in the fluticasone furoate arm. No safety concerns were identified. Discussion Themes.

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Rethinking Clinical Trials

FEBRUARY 16, 2023

If they did not opt-out within a month, we would monitor their prescription refills and send a nudge if one went unfilled for more than 7 days. Discussion Themes – How did the various types of notifications in the ICD-Pieces study impact opt-outs? Participants always know some things and agree to some extent.

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Intouch Solutions

NOVEMBER 30, 2021

blue links) of the organic results appeared to be pulling from content outside of the HTML title tag at a much higher frequency. This means all PDFs were excluded, as well as any URLs where data company Ahrefs did not record a SERP title within the given timeframes. Specifically, title links (i.e., Screaming Frog, Ahrefs, GSC, etc.).

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Rethinking Clinical Trials

FEBRUARY 28, 2024

Did participants receive the assigned treatment and did they stay on the treatment? Tags #pctGR, @Collaboratory1 The post Grand Rounds February 23, 2024: Virtual Vigilance: Monitoring of Decentralized Clinical Trials (Adrian Hernandez, MD; Christopher J. Was there complete ascertainment of primary and secondary efficacy data?

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Rethinking Clinical Trials

FEBRUARY 20, 2024

The results of the MINT trial did not demonstrate a statistically significant difference in the rate of 30-day death or recurrent MI in patients with acute MI and anemia assigned to a restrictive compared to a liberal transfusion strategy. Discussion Themes -When did you consent the patients – before or after the cath lab?

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Rethinking Clinical Trials

DECEMBER 6, 2022

– Did the mHealth group receive text messages on pill adherence? Patients did not get text messages about pill adherence. We did what we could to make the entry criteria as easy as possible. The median time to liberation in the HFNC group was 50 hours and the CPAP group was 43 hours. Discussion Themes.

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Rethinking Clinical Trials

JULY 22, 2022

– How did the public-private partnership contributed to the success of ACTIV? Five agents are still in testing. Each protocol has had many lessons learned. Across all is the need for clear communication, resources, and partnerships. Discussion Themes. Read more in Annals of Internal Medicine and Critical Care Medicine.

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Rethinking Clinical Trials

JUNE 7, 2023

John Alexander: One of the things we did in PROACT X-a is we allowed flexibility. There were sites that did no remote consent or enrollment. Then others did remote. We said that was fine. At times they changed their mind, based on other people doing it. There were some sites that allowed remote within a specific region.

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Rethinking Clinical Trials

MARCH 28, 2023

We did achieve a lot of the things we talked about in the first year, many of which we did not think were achievable. Learn more PCORnet Front Door Discussion Themes – Is there anything about what PCORnet®. Those are the areas we are looking at moving forward.

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Rethinking Clinical Trials

SEPTEMBER 16, 2022

A next step would be to do after action reports on what they did; what did we do that we could learn from and reorganize ourselves? How do we strategically choose the things that are the most important given the resources available? – Is this ethically problematic that we don’t have LHS proceeding in academic medical centers?

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Rethinking Clinical Trials

AUGUST 22, 2022

How did the trial handle recruitment? A pre-specified secondary analysis of the primary outcome indicates a substantial reduction in ED visits, hospitalizations, and death from COVID-19 with Metformin. Discussion Themes. It was a huge challenge. We started only looking within the participating health system and sites. pctGR, @Collaboratory1.

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Rethinking Clinical Trials

SEPTEMBER 13, 2023

Discussion Themes -Why did the RSI trial follow a different path – not a waiver of consent? Tags #pctGR, @Collaboratory1 The post Grand Rounds September 8, 2023: The DEVICE Trial: An Embedded, Pragmatic Trial of Emergency Airway Management (Matthew Prekker, MD, MPH; Jonathan Casey, MD, MSc) appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

MAY 25, 2023

The research team did not run into institutional barriers in the trial, likely because of the opportunity of Aspirin to be a much lower cost option if proven safe and effective. -Clinician buy-in and understanding the social component of clinical work was essential to the pragmatic trial.

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Rethinking Clinical Trials

OCTOBER 26, 2023

Discussion Themes – When did NIH begin to think a program like this was possible? Tags #pctGR, @Collaboratory1 The post Grand Rounds October 20, 2023: A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists (Rachael L. The current trends of Hepatitis C epidemiology in the U.S.

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Rethinking Clinical Trials

MAY 5, 2023

This was also true for all prespecified subgroups, and the 3 target groups did not differ for the secondary, exploratory, and safety outcomes. For many patients, this did not happen. Discussion Themes -What was the experience doing these repeated crossovers?

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Rethinking Clinical Trials

MAY 19, 2023

They estimated 5,000 hours to put it in the EHR, and they did it for free. Tags #pctGR, @Collaboratory1 The post Grand Rounds May 12, 2023: Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension (Richelle J. We are evaluating the usability of the app.

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Rethinking Clinical Trials

NOVEMBER 21, 2023

– How did the messages account for prescription dosage changes? Messages included PHI but the study followed the institutional security protocols that allowed the intervention to be approved. Patients could reply with Done and the message reminders would stop. The study would then recalculate the gaps.

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Rethinking Clinical Trials

DECEMBER 12, 2023

Discussion Themes -Within individual physicians, did you see an increase in goals of care discussions? Jumpstart may be useful in enhancing equity in serious illness communication among racially or ethnically minoritized patients. Learn more Read more in JAMA and a JAMA editorial. Clinicians could receive prompts on an almost daily basis.

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FDA Law Blog

JULY 20, 2021

The new rule applies not only to product labeling, but to any “mail order catalog” or “mail order promotional material” that includes a seal, mark, tag, or stamp that labels a product as having been made in the United States.

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Pharmaceutical Technology

JUNE 29, 2022

For example, while orphan drug designations have more than doubled in the last decade compared to the previous one, only 16% of therapies with orphan tags have managed to gain FDA approval in some indications.

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Drugs FDA Approval Marketing Development 246

Rethinking Clinical Trials

APRIL 27, 2023

Did some of these questions of autonomy vs. risk come up? Tags #pctGR, @Collaboratory1 The post Grand Rounds April 21, 2023: Personalised Cooler Dialysate for Patients Receiving Maintenance Haemodialysis (MyTEMP): A Pragmatic, Cluster-randomised Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N.

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XTalks

JUNE 8, 2021

With a price tag of over $2.5 At ten months old, Tora had become floppy and did not have any mobility. Prior to baseline, four patients (40 percent) in the treatment group required non-invasive ventilatory support, while six patients (60 percent) did not. This did not change in long-term follow-up.

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Rethinking Clinical Trials

FEBRUARY 9, 2023

– How did you derive and evaluate the evidence that was used in the IMPROVE-DD VTE CDS tool? The team also engaged with a diverse array of providers from multiple hospitals and specialties. It was important to observe behaviors in real time and be open to making changes at multiple points during the design and testing process.

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Rethinking Clinical Trials

AUGUST 28, 2023

Training is also going to be essential to move this forward. – How did the pandemic impact the updates to the guidance? We need to be clearer and more concise, while making sure that the statement fits with the needs of researchers. One important note is that we specifically moved away from a checklist approach.

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Rethinking Clinical Trials

AUGUST 28, 2023

Training is also going to be essential to move this forward. – How did the pandemic impact the updates to the guidance? We need to be clearer and more concise, while making sure that the statement fits with the needs of researchers. One important note is that we specifically moved away from a checklist approach.

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Rethinking Clinical Trials

SEPTEMBER 21, 2023

Which do you purchase the most?” – Did you have any intention to evaluate if the behavior would continue without the incentives? One thing we want to do in the future is pair with people who can help us do things that are more sophisticated, rather than just asking a question in a survey that says, “Here’s five options.

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The Pharma Data

MARCH 23, 2022

Unfortunately, in a Phase 3 clinical trial, treatment with remdesivir did not make a difference in mortality for Ebola virus disease patients. This special enzyme, once fused to Ebola virus polymerase, enables the polymerase to add a molecular tag to any other protein it interacts with.

Protein 52

Protein Genome Genomics Research 52

pharmaphorum

MAY 10, 2022

The FDA awarded a fast-track designation to lecanemab in December and has also given the drug breakthrough tag as a treatment for early-stage Alzheimer’s, and Biogen and Eisai will be hoping the drug can sidestep the controversy that engulfed Aduhelm from the moment it was approved.

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pharmaphorum

JANUARY 31, 2023

What people did not understand was that “fast tracking” approval does not limit the rigorous process involved in ensuring that a medication or vaccine is safe for market use. Given the high price tags placed on many medications, it’s easy to understand why patients often feel that they are being taken advantage of.

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Clinical Trials Clinical Trials Trials Vaccination 52

XTalks

OCTOBER 12, 2022

Although the tumor size did not change by Day 2, the tumor vascular parameters had sharply decreased, which shows that there was a good shutdown of the vasculature within that tumor. For ASL MR perfusion, water molecules in arterial blood from a feeder artery are magnetically tagged and tracked until they reach the region of interest.

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Clinical Trials Clinical Trials Trials Drugs 93

XTalks

APRIL 6, 2021

Where flour, pasta and other shelf-stable goods once sat in abundance quickly emptied to nothing but price tags. So how did the food system react and adapt to the pandemic and how has it strengthened over the year? How did this happen so quickly? The same went for meat and dairy. It was a shocking, yet humbling, sight for most.

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Production Sales Vaccination Vaccine 104

pharmaphorum

JUNE 2, 2022

R&D into orphan drugs is growing alongside the number of approved treatments, providing treatments for rare diseases that previously did not have any. Raising questions.

Drugs 52

Drugs Sales Marketing Development 52

pharmaphorum

DECEMBER 2, 2020

Leif Johansson, AZ’s chairman, did not mince his words, saying: “Pfizer’s approach throughout its pursuit of AstraZeneca appears to have been fundamentally driven by the corporate financial benefits to its shareholders of cost savings and tax minimisation. This did not stymie Pfizer’s desire to move its HQ out of the US, though.

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Rethinking Clinical Trials

FEBRUARY 2, 2023

– How did you navigate the IRB process? At Vanderbilt, we did not have any contact internally with the IRB. Tags #pctGR, @Collaboratory1 The post Grand Rounds January 27, 2023: The PREPARE II Trial: Embedding a Pragmatic Trial Into Clinical Care During an Emergency Procedure (Derek W. This trial used a mixed approach.

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Pharma Marketing Network

OCTOBER 4, 2020

Don ( PMN): Yeah and that might be a concern for some folks out there that who’s websites are supported by advertising because you’re relying upon another third-party that can be adding load time to a site when you’re when you’re add tags are loading.

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Doctors Doctor Marketing Packaging 52