Drug Discovery World

MARCH 2, 2023

A new paper has solved the 20-year mystery of how epigenetic modifications act as traffic lights to control gene expression and could ultimately speed up the development of a new class of epigenetic cancer drugs. Epigenetics is still largely unexplored and referred to as the ‘dark matter’ of the genome.

Gene Expression 52

Gene Expression Gene DNA RNA 52

The Pharma Data

MARCH 7, 2022

Because these modifications occur not in, but on top of genes, they are called epigenetic, from the Greek epi “over” or “above” the genes. The chemical modifications that regulate gene activity are called epigenetic markers. Cas9 binds and uses RNA as an address-tag.

Protein 52

Protein Gene Genome Genomics 52

Drug Discovery World

OCTOBER 31, 2022

Click’ chemistry used to tag proteins made by cancer cells. Epigenetics vital in predicting cancer drug outcomes. A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London. .

Drugs 52

Drugs Research Gene Editing Protein 52

Delveinsight

FEBRUARY 25, 2021

A team of Canadian researchers is suggesting a new combination strategy for enhancing the response of the immune system’s T cells to immuno-oncology drugs, and it comprises epigenetics. The researchers had previously discovered that when mouse tumors were treated with epigenetic drugs, there was an increase in T cells infiltrating cancer.

DNA 52

DNA In-Vivo Genetics Medicine 52

pharmaphorum

DECEMBER 23, 2022

price tag of $475,000 when it was first launched in 2017 – and it becomes apparent that these may not be desirable treatment options for every patient and in every setting. Results suggest durable epigenetic re-wiring and provide rationale for intermittent clinical dosing.

Development 52

Development Drugs Clinical Development Antibody 52

XTalks

FEBRUARY 11, 2021

They conducted two experiments, one with radioactive phosphorous to label DNA, and one with radioactive sulfur to tag protein (DNA does not contain sulfur and protein does not contain phosphate groups). Through the radioactive labels, they were able to track which of the two, DNA or protein, was injected into the bacteria.

Genetics 119

Genetics DNA Genome Genomics 119