Rethinking Clinical Trials

NOVEMBER 21, 2022

What we found from the pilot RCT, was that there were two distinct populations, step-up (i.e., For the step-down RCT, patient recruitment started in August 2019 with 587 patients consenting and 552 included in the primary analysis. acutely ill patients) and step-down, which is the extubation or post-extubation part of the care pathway.

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Rethinking Clinical Trials

DECEMBER 20, 2023

Increasing diversity in trial leadership is one of the most important strategies to increase diversity among RCT participants. Tags #pctGR, @Collaboratory1 The post Grand Rounds December 15, 2023: Diversifying Clinical Trials: A Path Forward (Roxana Mehran, MD, FACC, FAHA, MSCAI, FESC) appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

DECEMBER 6, 2022

For the step-down RCT, patient recruitment started in August 2019 with 587 patients consenting and 552 included in the primary analysis. The median time to liberation in the HFNC group was 50 hours and the CPAP group was 43 hours. It was a labor of love; the site payment was low; we asked friends to be sites in the trial.

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Rethinking Clinical Trials

SEPTEMBER 22, 2022

The DANFLU-1 trial is a large-scale pragmatic RCT that looked at high-dose vs standard-dose flu vaccine to test whether high-dose vaccines might reduce hospitalizations among the elderly, age 65 and older. The DECODE trial used registry data to identify patients with chronic kidney disease. Learn more. Read about DANFLU-1.

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Rethinking Clinical Trials

JANUARY 23, 2024

RCT design will vary depending on which CAD manifestation(s) are reflected in the information provided by the imaging test being studied, which affects the treatment target(s) being evaluated in a therapeutic trial. Tags #pctGR, @Collaboratory1 The post Grand Rounds January 19, 2024: Why Are Imaging RCTs Different?

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Rethinking Clinical Trials

FEBRUARY 2, 2023

Without RCTs we cannot know which treatments are helpful and which are not. Embedding RCT procedures within emergency care can deliver treatments in the manner that they are delivered in clinical care, collecting data on which clinicians and patients base decisions, and it can enroll diverse and representative trial populations.

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Rethinking Clinical Trials

JUNE 14, 2023

Tags #pctGR, @Collaboratory1 The post Grand Rounds June 9, 2023: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative (Shirley V. In any trial emulation, researchers encounter design emulation differences in addition to potential sources of bias.

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