The INSPIRE NIH Collaboratory Trial went live this month, with a new order entry screen being activated in the electronic health record at 51 hospital sites randomized to the intervention.
Congratulations to lead investigator Dr. Shruti Gohil, co–principal investigators Dr. Susan Huang and Dr. Richard Platt, and the INSPIRE team!
INSPIRE is studying the effectiveness of a personalized clinical decision support program in improving antibiotic prescribing for non–critically ill patients hospitalized with abdominal infections or skin and soft tissue infections. The trial is comparing routine care under hospital-based antibiotic stewardship programs with an enhanced program that adds a predictive algorithm to reduce unnecessary prescribing of extended-spectrum antibiotics.
The computerized provider order entry system at sites in the intervention group prompts physicians when the antibiotic they select is discordant with the estimated need for that antibiotic. The 18-month study will evaluate approximately 53,000 patients with abdominal infections and approximately 37,000 patients with skin or soft tissue infections.
INSPIRE is supported within the NIH Pragmatic Trials Collaboratory by a grant from the National Institute of Allergy and Infectious Diseases (NIAID).