Rethinking Clinical Trials

JANUARY 22, 2024

In a new article from the NIH Pragmatic Trials Collaboratory, investigators from 6 of the program's completed pragmatic clinical trials summarize the posttrial interpretation of their trials' results and consider the factors that influenced the sustainment or de-implementation of the studies' interventions. Read the full article.

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Rethinking Clinical Trials

JANUARY 11, 2024

In a new article from the NIH Pragmatic Trials Collaboratory, the BeatPain Utah study team describes the "implementation mapping" they used to plan for trial implementation. Learn more about BeatPain Utah. The article was published this month in Implementation Science Communications.

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Rethinking Clinical Trials

APRIL 4, 2024

ICD-Pieces, an NIH Collaboratory Trial , was a cluster randomized, pragmatic clinical trial testing an intervention that used an electronic health record–based algorithm and practice facilitators in 141 primary care practices. Vazquez also emphasized the value of conducting the ICD-Pieces study as an NIH Collaboratory Trial.

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Rethinking Clinical Trials

DECEMBER 18, 2023

Ethics and regulatory onboarding documentation for 2 of the NIH Pragmatic Trials Collaboratory's newest trials is now available. Learn more about ARBOR-Telehealth. Learn more about I CAN DO Surgical ACP. Both projects are in their planning phase. View the ethics and regulatory documentation for ARBOR-Telehealth.

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Rethinking Clinical Trials

AUGUST 1, 2023

If you are active on LinkedIn, we invite you to follow our page for the latest news about our innovative Demonstration Projects, tools and resources from the Core Working Groups, upcoming sessions of our weekly Rethinking Clinical Trials Grand Rounds webinar series, and fresh content from the Living Textbook of Pragmatic Clinical Trials.

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FEBRUARY 20, 2023

NIH Pragmatic Trials Collaboratory Fact Sheet A handout providing information about the NIH Collaboratory and pragmatic clinical trials The post NIH Pragmatic Trials Collaboratory Fact Sheet appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

AUGUST 3, 2023

This year’s Annual Steering Committee Meeting for the NIH Pragmatic Trials Collaboratory featured implementation science as one of the topics of focus. The earlier researchers can think about their interventions being used beyond the trial, the better,” Chambers explained.

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Rethinking Clinical Trials

MARCH 15, 2023

IMPACt-LBP, an NIH Pragmatic Trials Collaboratory Demonstration Project, enrolled its first study participant this week. Learn more about IMPACt-LBP in this interview with investigators Christine Goertz, Adam Goode, and Rishi Chakraborty. Congratulations to the IMPACt-LBP study team for reaching this important project milestone!

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Rethinking Clinical Trials

JULY 31, 2023

The NIH this month published notice of a funding opportunity to support the next round of pragmatic clinical trials within the NIH-DoD-VA Pain Management Collaboratory (PMC). Learn more about the PMC. Learn more about the PMC. Read the full notice of funding opportunity (RFA-AT-24-004).

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Rethinking Clinical Trials

JUNE 29, 2023

For alerts about new episodes, subscribe free on Apple Podcasts or SoundCloud. Click on the recording below to listen to the podcast. View the full Grand Rounds presentation. Read the transcript.

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Rethinking Clinical Trials

JULY 27, 2023

Leaders of the NIH Pragmatic Trials Collaboratory hosted an onboarding meeting for the program’s 3 newest Demonstration Projects. During the session, NIH Collaboratory leaders provided an overview of the program, the cooperative agreement support mechanism, and the program’s policies and guidance documents.

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Rethinking Clinical Trials

FEBRUARY 6, 2024

This was the finding of a secondary analysis of data from the Trauma Survivors Outcomes and Support (TSOS) study, an NIH Pragmatic Trials Collaboratory Trial. Patients in the control group received usual care plus nurse notification about their high level of distress. Learn more about the NIH Collaboratory Trials.

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Rethinking Clinical Trials

JULY 19, 2023

For alerts about new episodes, subscribe free on Apple Podcasts or SoundCloud. Click on the recording below to listen to the podcast.  View the full Grand Rounds presentation. Read the transcript.

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Rethinking Clinical Trials

OCTOBER 10, 2023

Ethics and regulatory onboarding documentation for the NIH Pragmatic Trials Collaboratory’s newest Demonstration Projects are now available. Learn more about BEST-ICU. Learn more about Chat 4 Heart Health. Learn more about TAICHIKNEE. All of the projects are in their 1-year planning phase.

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Rethinking Clinical Trials

APRIL 24, 2023

For alerts about new episodes, subscribe free on Apple Podcasts or SoundCloud. Click on the recording below to listen to the podcast. View the full Grand Rounds presentation. Read the transcript.

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Rethinking Clinical Trials

NOVEMBER 29, 2022

The NIH Pragmatic Trials Collaboratory is excited to welcome the INSPIRE Demonstration Project to its portfolio of innovative, large-scale pragmatic clinical trials embedded in healthcare systems. Huang and Platt are experienced investigators in the NIH Collaboratory. Shruti Gohil. Susan Huang. Dr. Richard Platt.

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Rethinking Clinical Trials

JUNE 22, 2023

Taunton Paine, Director of the NIH Scientific Data Sharing Policy Division At the annual NIH Pragmatic Trials Collaboratory Steering Committee meeting in May, we interviewed Taunton Paine, director of the NIH Scientific Data Sharing Policy Division, about the NIH’s new Data Management & Sharing Policy , which took effect in 2023.

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Rethinking Clinical Trials

OCTOBER 5, 2023

The GRACE trial, an NIH Pragmatic Trials Collaboratory Demonstration Project, was featured in a segment on CBS News Chicago. The study is supported by the NIH through the NIH HEAL Initiative under an award administered by the National Center for Complementary and Integrative Health. Learn more about the GRACE trial.

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Rethinking Clinical Trials

JUNE 29, 2023

In the latest episode of the NIH Collaboratory Grand Rounds podcast , Dr. Joshua Denny continues his discussion about All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine. The full May 5 Grand Rounds webinar with Dr. Denny is also available.

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Rethinking Clinical Trials

FEBRUARY 13, 2024

Steven George The NIH Pragmatic Trials Collaboratory published a new chapter in its Living Textbook of Pragmatic Clinical Trials. Because patients can provide valuable insights and perspectives about clinical care for specific conditions, they are key partners for pragmatic clinical trials. Read more about the Living Textbook.

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Rethinking Clinical Trials

FEBRUARY 12, 2024

Steven George The NIH Pragmatic Trials Collaboratory published a new chapter in its Living Textbook of Pragmatic Clinical Trials. Because patients can provide valuable insights and perspectives about clinical care for specific conditions, they are key partners for pragmatic clinical trials. Read more about the Living Textbook.

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Rethinking Clinical Trials

NOVEMBER 1, 2022

The NIH Pragmatic Trials Collaboratory will offer a full-day preconference workshop at the 2023 Health Care Systems Research Network (HSCRN) Annual Conference in Denver, Colorado. NIH Pragmatic Trials Collaboratory Preconference Workshop. CONFERENCE & WORKSHOP DETAILS AND REGISTRATION. 2023 HCSRN Annual Conference.

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Rethinking Clinical Trials

AUGUST 14, 2023

Kevin Weinfurt and Greg Simon reflected on cross-Core collaboration within the NIH Pragmatic Trials Collaboratory and opportunities for growth in the future. So many of the decisions about pragmatic trials involve compromise,” said Simon, chair of the Health Care Systems Interactions Core. “It

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Rethinking Clinical Trials

FEBRUARY 26, 2024

PRIM-ER, an ongoing NIH Collaboratory Trial, is a stepped-wedge, cluster randomized trial testing a multidisciplinary primary palliative care intervention in a diverse mix of emergency departments in the United States. Read more about PRIM-ER. The results of the study were published last week in BMC Palliative Care.

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Rethinking Clinical Trials

MARCH 14, 2023

NIH Pragmatic Trials Collaboratory · Podcast 44: The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials NIH Pragmatic Trials Collaboratory · Podcast 43: Ethical Considerations for Vulnerable Populations in Pragmatic Clinical Trials Want to hear more? View the full Grand Rounds presentation.

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Rethinking Clinical Trials

JUNE 22, 2023

Researchers from EMBED, an NIH Pragmatic Trials Collaboratory Demonstration Project, found a sharp rise in out-of-hospital overdose deaths in the early years of the COVID-19 pandemic, attributable largely to increasing involvement of fentanyl. Read the full report.

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Rethinking Clinical Trials

JUNE 14, 2023

Updated study snapshots and ethics and regulatory documentation are now available for the IMPACt-LBP and INSPIRE trials, both NIH Pragmatic Trials Collaboratory Demonstration Projects. IMPACt-LBP is supported within the NIH Collaboratory under an award from the National Center for Complementary and Integrative Health.

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Rethinking Clinical Trials

FEBRUARY 6, 2023

In the latest episode of the NIH Collaboratory Grand Rounds podcast , Dr. Emily Largent and Dr. Stephanie Morain continue their discussion about the ethical considerations for vulnerable populations participating in pragmatic clinical trials. The full January 13 Grand Rounds webinar with Dr. Largent is also available.

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Rethinking Clinical Trials

MAY 11, 2023

A new article from the NIH Pragmatic Trials Collaboratory outlines stakeholder insights and ethical considerations related to sharing deidentified, participant-level data in pragmatic clinical trials. The article was published this month in Learning Health Systems. Read the full report.

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Rethinking Clinical Trials

JUNE 26, 2023

Vazquez, MD and George Oliver, MD, PhD presented at the NIH Pragmatic Trials Collaboratory Grand Rounds on June 23, 2023. Learn more about the Improving Chronic Disease Management with Pieces (ICD-Pieces trial. They presented on the topic of Improving Delivery of Care for Chronic Kidney Disease, Diabetes in Hypertension.

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Rethinking Clinical Trials

JULY 3, 2023

In a new article published online ahead of print in JAMIA , the NIH Pragmatic Trials Collaboratory’s Demonstration Project teams reflect on the health equity challenges encountered by their trials and share the specific strategies they used to mitigate sources of potential bias and increase the generalizability of research results.

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Rethinking Clinical Trials

MAY 22, 2023

EMBED, an NIH Collaboratory Demonstration Project, was a cluster randomized trial across 21 emergency departments in 5 healthcare systems in the United States. Read more about EMBED in the Living Textbook, and learn about the other Demonstration Projects. Read the full report.

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Rethinking Clinical Trials

FEBRUARY 14, 2023

Fan Li, a member of the NIH Pragmatic Trials Collaboratory’s Biostatistics and Study Design Core, will present “Methods for Designing Cluster Randomized Trials to Detect Treatment Effect Heterogeneity” during IMPACT Grand Rounds on Thursday, February 16, at 12:00 pm eastern.

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Rethinking Clinical Trials

JULY 14, 2022

In the latest episode of the NIH Collaboratory Grand Rounds podcast , Dr. John Concato and Dr. Richard Platt continue their discussion about the FDA draft guidance on real-world evidence. The full June 24 Grand Rounds webinar with Dr. Concato is also available.

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Rethinking Clinical Trials

MAY 15, 2023

EMBED, an NIH Collaboratory Demonstration Project, was a cluster randomized trial across 21 emergency departments in 5 healthcare systems in the United States. Read more about EMBED in the Living Textbook, and learn about the other Demonstration Projects. Read the full report.

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Rethinking Clinical Trials

JUNE 29, 2023

Materials and videocast recordings are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Getting the Right Evidence to Decision-Makers Faster. These trials are at higher risk for failure when the goals of the research and healthcare system operations are not aligned.

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Rethinking Clinical Trials

AUGUST 8, 2023

From left: Dr. Steven George, Dr. Vincent Mor, and Dr. Angelo Volandes In an interview at this year’s NIH Pragmatic Trials Collaboratory Steering Committee annual meeting, Drs. “We as investigators probably don’t think enough about how health systems operate,” Mor said.

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