The NIH Pragmatic Trials Collaboratory is launching a special Grand Rounds series to share advances in the design and analysis of pragmatic clinical trials.

Join us on the first Friday of each month, October through January, to hear the latest best practices and explore emerging questions with experts from the program’s Biostatistics and Study Design Core.

Over the past decade, the Core has worked with investigators to fine-tune study designs, develop rigorous analysis plans, and offer guidance to the broader community of researchers who are planning pragmatic trials. With this new Grand Rounds series, the Core is bringing together biostatisticians, clinical trials methodologists, and investigators to discuss challenges and share lessons learned in the design, implementation, and analysis of pragmatic trials.

The webinar series, Advances in the Design and Analysis of Pragmatic Clinical Trials, will kick off on Friday, October 6, at 1:00 pm ET with a presentation on design and analysis considerations for implementation trials by David Murray, NIH associate director for disease prevention and director of the NIH Office of Disease Prevention.

The series will include 3 additional moderated webinar discussions. These sessions will focus on a range of topics, including complex clustering, best practices in the design and analysis of stepped-wedge trials, and handling missing data in cluster randomized trials.

Download the series flyer and see the full schedule below:

• October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods (David M. Murray, PhD; Moderator: Jonathan Moyer, PhD)
• November 3, 2023: The Perils and Pitfalls of Complex Clustering in Pragmatic Trials (Jonathan Moyer, PhD; Moderator: Andrea Cook, PhD)
• December 1, 2023: Guidelines for Design and Analysis of Stepped-Wedge Trials (Jim Hughes, PhD; Moderator: Patrick Heagerty, PhD)
• January 5, 2023: Methods for Handling Missing Data in Cluster Randomized Trials (Rui Wang, PhD; Moderator: Fan Li, PhD)

All sessions are free and open to the public; no registration is required. Recordings will be archived on the Rethinking Clinical Trials website.