The NIH Pragmatic Trials Collaboratory is excited to announce the addition of 5 new large-scale pragmatic clinical trials to its portfolio of innovative NIH Collaboratory Trials, which will extend the program's mission to strengthen the national capacity to implement cost-effective, large-scale research studies that engage healthcare delivery organizations as research partners.

Three of the new projects are funded through the Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) program, a component of the Helping to End Addiction Long-Term Initiative℠, or NIH HEAL Initiative℠, to address the opioid crisis.

• Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP) is a pragmatic trial that will address the challenge of implementing effective, non-opioid interventions for chronic pain management in rural and remote dwelling veteran populations by developing an innovative telehealth evidence-based intervention to address veterans' biophysical, psychological, and social needs. The study is administered by the National Institute of Nursing Research and will be conducted by Diana Burgess of the Minneapolis Veterans Affairs Healthcare System, Roni Evans of the University of Minnesota, and Katherine Hadlandsmyth of the University of Iowa.
• Advancing Rural Back Pain Outcomes through Rehabilitation Telehealth (ARBOR-Telehealth) is a pragmatic trial that seeks to understand the effectiveness of telerehabilitation as a method of improving access to physical therapy for patients with chronic lower back pain living in rural communities and improving outcomes of these patients. The study is administered by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and will be conducted by Richard Skolasky Jr and Kevin McLaughlin of Johns Hopkins University.
• Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients with Chronic Pain (AIM-CP) is a pragmatic trial that seeks to address chronic pain outcomes for individuals living in rural communities by adapting, piloting, and implementing a nurse care management model to test its effectiveness as a nonpharmacologic treatment option. The study is administered by the National Institute of Nursing Research and will be conducted by Sebastian Tong and Kushang Patel of the University of Washington.

The NIH Pragmatic Trials Collaboratory is also adding 2 projects supported by grants from the National Institute of Nursing Research and the National Institute on Minority Health and Health Disparities.

• Maternal OutcoMes Program: Testing Integrated Maternal Care Model Approaches to Reduce Disparities in Severe Maternal Morbidity (MOMs Chat & Care Study) is a pragmatic trial that will test the effectiveness of an integrated care model approach at 2 different levels of intensity designed to facilitate timely, appropriate care for high-risk Black birthing people and reduce risk for severe maternal morbidity. The study is administered by the National Institute of Nursing Research and will be conducted by Stephanie Fitzpatrick of the Feinstein Institutes for Medical Research at Northwell Health.
• Implementing Scalable, PAtient-centered Team-based Care for Adults with Type 2 Diabetes and Health Disparities (iPATH) is a pragmatic trial that will refine and implement an approach to practice transformation originally conceived to support federally qualified health centers’ pursuit of National Committee for Quality Assurance recognition as patient-centered medical homes as a method of addressing disparities in diabetes care at federally qualified health centers. This study is administered by the National Institute on Minority Health and Health Disparities and will be conducted by Sara Singer of Stanford University.

These new NIH Collaboratory Trials join the 4 other trials added to the NIH Pragmatic Trials Collaboratory portfolio in 2023, which include BEST-ICU, Chat 4 Heart Health, I CAN DO Surgical ACP, and TAICHIKNEE.