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Underscoring the opaque and confusing nature of pharmaceutical pricing, Amgen announced long-awaited discounts for its biosimilar version of Humira — the world’s best-selling medicine — and the numbers suggest the biggest winners may be health insurers and others in the supply chain, but not patients.

Here’s why: The drug company will offer its medication, called Amjevita, at two different discounts — 5% and 55% — off the roughly $80,000 wholesale, or list, price. The maneuver reflects the behind-the-scenes negotiations that occur between pharmaceutical companies and the pharmacy benefit managers, or PBMs, that create formularies, or lists of medicines for which insurance coverage is provided.

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To win favorable placement, drug companies typically offer rebates, which the PBMs are supposed to pass along to health plans. But a big discount off the wholesale price means less money for PBMs to pass along to insurers while also capturing fees. So while a 55% discount sounds impressive, there is less incentive for a PBM to bite. In other words, the 5% discount is likely to be more popular with payers.

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