Rethinking Clinical Trials

MAY 5, 2023

Assistant Professor of Medicine and Biomedical Informatics Medical Director, VICTR Center for Learning Healthcare Vanderbilt University Medical Center Slides Keywords Pragmatic Clinical Trials, Cluster-crossover Trial Key Points More than 3 million adults receive invasive mechanical ventilation each year in the U.S.

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Rethinking Clinical Trials

FEBRUARY 13, 2023

The primary outcome was ventilator-free days (VFD) from start of cardiopulmonary bypass to day 28, with a number of secondary outcomes. The hypothesis was that patients with nitric oxide would recover quicker allowing for more ventilator-free days, but there was no difference between the intervention and standard of care.

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Rethinking Clinical Trials

NOVEMBER 21, 2022

Sick children, when they are acutely ill, start with standard oxygen therapy, which escalates to noninvasive respiratory support (CPAP/BIPAP or high flow nasal cannula) before invasive ventilation support in the ICU. Reader in Pediatric Critical Care. Imperial College London. Pragmatic Clinical Trials. Key Points.

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Rethinking Clinical Trials

FEBRUARY 2, 2023

There was an interesting consistent pattern of subgroups of patients who were exposed earlier or more intensive positive pressure ventilation modalities, such as non-invasive ventilation, that was applied earlier in the procedure seemed to have better outcomes. It was conducted with waiver of informed consent.

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