BioTech 365

JUNE 14, 2021

Twist Bioscience Collaborates with Regeneron for Production of Genotyping by Sequencing Panel to Enable Diverse Genome-wide Screening Twist Bioscience Collaborates with Regeneron for Production of Genotyping by Sequencing Panel to Enable Diverse Genome-wide Screening — Population Genetics Sequencing Panel Incorporates … Continue reading (..)

Genotype 52

Genotype Genome Genomics Genetics 52

Pharmaceutical Technology

SEPTEMBER 5, 2022

The treatment is indicated for CF patients who are homozygous for the F508del mutation (F/F genotype) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It enrolled 46 children aged one to under two years with the F/F genotype. According to the findings, Orkambi was found to be well tolerated.

FDA Approval 130

FDA Approval Genotype Clinical Trials Clinical Trials 130

Pharmaceutical Technology

AUGUST 18, 2022

0 genotypes. The latest approval is based on findings from the Phase III clinical trials, HGB-207 (Northstar-2) and HGB-212 (Northstar-3), and the long-term follow-up LTF-303 study. The open-label, single-arm, 24-month Phase III trials enrolled 41 subjects of the age four to 34 years with non-?0/?0

Gene Therapy 246

Gene Therapy Gene Genotype FDA Approval 246

Pharmaceutical Technology

JULY 4, 2022

Given subcutaneously, the antibody can hinder the entry of all ten HBV genotypes into hepatocytes and can also lower virion and subviral particle levels in the blood. A widely neutralising monoclonal antibody (mAb), VIR-3434 (BRII-877) acts on the hepatitis B virus (HBV). The mAb is presently in the Phase II development stage.

Antibody 279

Antibody Genotype Drugs Licensing 279

Medical Xpress

JANUARY 5, 2023

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care. This approach contrasts with the typical phenotype-first approach to clinical research, which starts with clinical findings.

Genome 75

Genome Genomics Genetics Genotype 75

BioTech 365

JUNE 11, 2021

thalassemia Continues to Demonstrate Durable Efficacy Across Pediatric and Adult Patient Populations and All Genotypes in Data Presented at EHA2021 Virtual betibeglogene autotemcel (beti-cel) One-Time Gene Therapy for ?-thalassemia betibeglogene autotemcel (beti-cel) One-Time Gene Therapy for ?-thalassemia

Gene Therapy 52

Gene Therapy Genotype Gene 52

BioTech 365

NOVEMBER 23, 2021

FDA as the First and Only Treatment for People Ages 12 and Older with Post-Transplant Cytomegalovirus (CMV), Refractory (With or Without Genotypic Resistance) to Conventional Antiviral Therapies Takeda’s LIVTENCITYTM (maribavir) Approved by U.S. Takeda’s LIVTENCITYTM (maribavir) Approved by U.S. FDA … Continue reading →

Genotype 52

Genotype 52

Medical Xpress

MARCH 17, 2023

The use of DBS samples for HCV RNA detection and genotyping was shown to effectively assess cure after treatment and to differentiate between reinfection and treatment failure. A study with people who inject drugs evaluated a minimally invasive test based on dried blood spots (DBS) for the monitoring of hepatitis C virus (HCV) infection.

Genotype 82

Genotype RNA Drugs 82

Worldwide Clinical Trials

FEBRUARY 6, 2023

The best course of action will depend on many variables, such as the disease or population being studied and the genotype/phenotype relationship, risk, and impact on care. Obtaining appropriate assistance to facilitate planning up front for the complexities involved will save sponsors time and effort in the long run.

Genetics 130

Genetics Clinical Trials Clinical Trials Genotype 130

Medical Xpress

FEBRUARY 3, 2023

For their paper published in the journal Science, Lorenzo Talamanca, Cédric Gobet and Felix Naef analyzed data obtained for the Genotype-Tissue Expression project. A trio of bioengineering scientists at Ecole Polytechnique Fédérale de Lausanne has found age and gender differences in gene expression related to the circadian clock.

Gene Expression 75

Gene Expression Gene Genotype Scientist 75

Medical Xpress

FEBRUARY 28, 2023

Using artificial intelligence (AI) methods, researchers led by Professor Dr. Alexander Schönhuth from Bielefeld University's Faculty of Technology have succeeded in recording and deciphering the genotype profiles of 3,000 ALS patients and thus learning more about the development of the disease.

Genotype 75

Genotype Development Research 75

Medical Xpress

MARCH 22, 2023

Fiber intake is associated with a lower risk of developing cognitive decline in those old people with the apolipoprotein E ApoE ε4 genotype, regarded as a genetic risk factor linked to the development of Alzheimer's disease.

Genotype 75

Genotype Genetics Pharmacy Research 75

BioTech 365

DECEMBER 5, 2020

thalassemia Genotypes Achieve Transfusion Independence and Remain Free from Transfusions Up to Six Years Presented at 62nd ASH Meeting Long-Term Data for bluebird bio’s betibeglogene … Continue reading → Long-Term Data for bluebird bio’s betibeglogene autotemcel (beti-cel) Gene Therapy Show Patients Across Ages and ?-thalassemia

Gene Therapy 52

Gene Therapy Genotype Gene 52

pharmaphorum

JANUARY 18, 2023

Pharmaceutical companies and biotechs are also adapting their approaches, launching patient finding and engagement programmes that can start years before clinical trials begin and allow them to run ‘recontact by genotype’ studies that the Resilience Project would have liked to do. Giving participants something in return.

Genetic Disease 97

Genetic Disease Genetics Genotype Genome 97

Drug Discovery World

MAY 3, 2023

The combination of Roche’s expertise in the local microbiology market and the ABLD product portfolio will reportedly make it easier for laboratories to access robust genotyping by sequencing solutions at competitive prices and with local support.

Genotype 52

Genotype RNA Drugs Production 52

The Pharma Data

SEPTEMBER 2, 2020

The decision allows use of the therapy in the EU in children as young as six years of age and weighing at least 17kg, regardless of HCV genotype or liver disease severity. Source link.

Genotype 52

Genotype Clinical Trials Clinical Trials Trials 52

Scienmag

APRIL 19, 2022

An estimated 100,000 Australians carry the high-risk genotype for Hemochromatosis, a condition affecting people of northern European descent which sees the body accumulate too much iron. It […].

Genetics 62

Genetics Genotype Research 62

Scienmag

JUNE 10, 2021

Latest joint consensus guideline authored by representatives from AMP, CAP, Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy ROCKVILLE, Md.

Genotype 71

Genotype Medicine 71

Scienmag

JUNE 23, 2022

170 GWAS derived SNPs were genotyped on 3000 replication samples from participants in Ethiopia, Ghana, and […]. Orofacial clefts (OFCs) are congenital birth defects where the independently derived facial primordia that form the orofacial complex fail to fuse properly during embryonic development.

Genotype 58

Genotype Genome Genomics Development 58

BioTech 365

JULY 20, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Untrained beer drinkers can taste different barley genotypes.When it comes to craft beer, the flavor doesn’t have to be all in the hops. As a panel of … Continue reading →

Genotype 40

Genotype Research 40

Drug Discovery World

JANUARY 20, 2023

Standard treatment for some cancers now include genotyping or molecular imaging in living patients. The massive data sets generated from this research have driven advances in data science and are used to inform additional studies and clinical practice. This is an extraordinarily exciting time to be involved in precision medicine for cancer.

Medicine 52

Medicine Genotype RNA Protein 52

Pharmaceutical Technology

JUNE 6, 2023

Pharma Mar offers in vitro diagnostic products used for detection of virus and bacteria in respiratory infections and human papilloma virus genotypes, among others. Pharma Mar also offers kits used for diagnosis of influenza A and B and respiratory syncytial virus. Its development pipeline includes PM14 for solid tumors, among others.

Hormones 100

Hormones Genotype In-Vitro Clinical Trials 100

Drug Discovery World

OCTOBER 30, 2023

RA: You’ve recently announced a collaboration with the University of Oxford to access genotype data on women with endometriosis. We previously conducted a hypothesis-free study using genotype data from the UK Biobank, which resulted in the first mechanism-based stratification of endometriosis patients.

Clinical Trials 72

Clinical Trials Clinical Trials Genotype Genome 72

Drug Discovery World

SEPTEMBER 5, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. However, hepatoma lines may lack the key proteins essential for modeling.

Drugs 59

Drugs Gene Therapy Genotype Protein 59

Scienmag

DECEMBER 15, 2020

Striving for a better understanding of pest resistance in experimental lines Credit: Gurjit Singh Tifton, Georgia: A study out of the University of Georgia sought to determine the level of host plant resistance that can be assured by several promising experimental bermudagrass genotypes against potential damages committed by the fall armyworm.

Genotype 66

Genotype Research Production 66

Scienmag

AUGUST 25, 2020

Credit: Iliana Baums, Penn State Coral conservation efforts could get a boost from a newly developed genotyping “chip”–the first of its kind for corals.

Genotype 66

Genotype Genetics Research Development 66

Drug Discovery World

SEPTEMBER 19, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Genotype Protein 52

Drug Discovery World

SEPTEMBER 26, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. However, hepatoma lines may lack the key proteins essential for modeling.

Drugs 52

Drugs Gene Therapy Genotype Protein 52

Drug Discovery World

SEPTEMBER 12, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Drugs Genotype 52

Drug Discovery World

JULY 3, 2023

The OXEGENE dataset contains anonymised genotype data including disease stage and infertility status, from 1,000 surgically confirmed patients. Endometriosis affects 10% of women globally, but on average it takes over seven years for patients to receive a diagnosis.

Genotype 52

Genotype Genetics Medicine Gene 52

Drug Discovery World

AUGUST 25, 2023

Also, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. Hepatocellular carcinoma-derived cell lines, such as HepG2s, are less proliferative than CHO or HEK cells but remain readily expandable and retain aspects of hepatocyte function.

Gene Therapy 52

Gene Therapy Gene Drugs Genotype 52

Drug Discovery World

OCTOBER 4, 2022

Within the past year, BioIVT has undertaken a programme to annotate thousands of biospecimens with next-generation sequencing data (NGS), creating the largest biorepository of biospecimens with mutation or genotype data. .

Genotype 52

Genotype Clinical Research Drugs Research 52

Scienmag

JANUARY 13, 2021

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies. A new statistical method, developed […].

Genome 57

Genome Genomics Genotype Genetics 57

Pharmaceutical Technology

DECEMBER 15, 2022

Therefore, there is also a significant need for new therapies that target the underlying cause of CFD that may offer a cure for patients living with severe disease, or for patients with genotypes such as dysfibrinogenemia and hypodysfibrinogenemia, who are often ineligible for treatment with HFCs.

Gene Therapy 130

Gene Therapy Marketing Genotype Drugs 130

Delveinsight

DECEMBER 13, 2020

Hepatitis C treatment options, without a doubt, have improved significantly, including pan-genotypic medications that are used to treat all genotypes and subtypes. Typically, pan-genotypic treatments have high cure rates, few side effects, and short treatment durations (usually 8–12 weeks). and GT2 and GT3 with ribavirin.

Genotype 52

Genotype FDA Approval Drugs Clinical Trials 52

Scienmag

MAY 16, 2021

The fully human monoclonal antibody produced sustained reductions in triglyceride levels of up to 82 percent, depending on the patient’s genotype, while also lowering the […].

Antibody 45

Antibody Genotype Drugs Clinical Trials 45

pharmaphorum

JANUARY 21, 2022

The findings have been submitted to the Genotype-to-Phenotype National Virology Consortium (G2P-UK), the New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) and the Joint Committee on Vaccination and Immunisation (JCVI). Overall, antibody levels were nearly 2.5

Antibody 115

Antibody Vaccination Vaccine Genotype 115