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SSRgenotyper: A new tool to digitally genotype simple sequence repeats

Scienmag

SSRgenotyper: A simple sequence repeat genotyping application for whole-genome resequencing and reduced representational sequencing projects. Credit: Lewis, D. Jarvis, and P. Maughan.

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SpeeDx Build Further Coverage in SARS-CoV-2 Genotyping Reagent Portfolio

BioTech 365

SpeeDx Build Further Coverage in SARS-CoV-2 Genotyping Reagent Portfolio SpeeDx Build Further Coverage in SARS-CoV-2 Genotyping Reagent Portfolio Rapid development of key mutation detection reagents continues to facilitate critical investigation and monitoring activities SYDNEY–(BUSINESS WIRE)–#COVID19–SpeeDx Pty. Ltd.,

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NRGene Accelerates Growth with a New Office and Genotyping Lab in Canada

BioTech 365

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Twist Bioscience Collaborates with Regeneron for Production of Genotyping by Sequencing Panel to Enable Diverse Genome-wide Screening

BioTech 365

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#news #biotech SSRgenotyper: A new tool to digitally genotype simple sequence repeats

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: SSRgenotyper: A new tool to digitally genotype simple sequence repeats.SSRgenotyper is a newly developed, free bioinformatic tool that allows researchers to digitally genotype sequenced populations using simple … Continue reading → #news

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AMP recommends minimum set of pharmacogenetic alleles to guide clinical CYP2D6 genotype testing, pro

Scienmag

Latest joint consensus guideline authored by representatives from AMP, CAP, Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy ROCKVILLE, Md. – June 10, 2021 – The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical […]. Medicine & Health Medicine/Health

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#news #biotech Untrained beer drinkers can taste different barley genotypes

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Untrained beer drinkers can taste different barley genotypes.When it comes to craft beer, the flavor doesn’t have to be all in the hops. As a panel of … Continue reading → #news

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betibeglogene autotemcel (beti-cel) One-Time Gene Therapy for ?-thalassemia Continues to Demonstrate Durable Efficacy Across Pediatric and Adult Patient Populations and All Genotypes in Data Presented at EHA2021 Virtual

BioTech 365

thalassemia Continues to Demonstrate Durable Efficacy Across Pediatric and Adult Patient Populations and All Genotypes in Data Presented at EHA2021 Virtual betibeglogene autotemcel (beti-cel) One-Time Gene Therapy for ?-thalassemia

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Long-Term Data for bluebird bio’s betibeglogene autotemcel (beti-cel) Gene Therapy Show Patients Across Ages and ?-thalassemia Genotypes Achieve Transfusion Independence and Remain Free from Transfusions Up to Six Years Presented at 62nd ASH Meeting

BioTech 365

thalassemia Genotypes Achieve Transfusion Independence and Remain Free from Transfusions Up to Six Years Presented at 62nd ASH Meeting Long-Term Data for bluebird bio’s betibeglogene … Continue reading → Business Wire

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EU OKs paediatric use of Gilead's Epclusa

The Pharma Data

The decision allows use of the therapy in the EU in children as young as six years of age and weighing at least 17kg, regardless of HCV genotype or liver disease severity. The decision allows use of the therapy in the EU in children as young as six years of age.

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US FDA approves Vertex’s Orkambi for cystic fibrosis in children

Pharmaceutical Technology

The treatment is indicated for CF patients who are homozygous for the F508del mutation (F/F genotype) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It enrolled 46 children aged one to under two years with the F/F genotype.

Genotype 130
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Brii Bio acquires Vir’s antibody rights for Hepatitis B in Greater China

Pharmaceutical Technology

Given subcutaneously, the antibody can hinder the entry of all ten HBV genotypes into hepatocytes and can also lower virion and subviral particle levels in the blood.

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FDA grants approval for bluebird’s Zynteglo to treat beta-thalassemia

Pharmaceutical Technology

0 genotypes. The US Food and Drug Administration (FDA) has granted approval for bluebird bio ’s Zynteglo (betibeglogene autotemcel, beti-cel) for the treatment of the underlying genetic cause of beta?thalassemia thalassemia in adult and paediatric patients.

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Crucial link found between arthritis, liver disease and a common genetic condition

Scienmag

An estimated 100,000 Australians carry the high-risk genotype for Hemochromatosis, a condition affecting people of northern European descent which sees the body accumulate too much iron. New Edith Cowan University (ECU) research has identified a crucial link between arthritis and the risk of serious liver disease in people with Australia’s most common genetic condition.

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African cleft GWAS signal replication in an independent African cohort

Scienmag

170 GWAS derived SNPs were genotyped on 3000 replication samples from participants in Ethiopia, Ghana, and […]. Orofacial clefts (OFCs) are congenital birth defects where the independently derived facial primordia that form the orofacial complex fail to fuse properly during embryonic development. Recent African genome-wide association studies (GWAS) for OFCs identified 170 near significant SNPs (p=10-5).

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Why early participant engagement is now a top priority in genetic disease research

Pharma Phorum

Pharmaceutical companies and biotechs are also adapting their approaches, launching patient finding and engagement programmes that can start years before clinical trials begin and allow them to run ‘recontact by genotype’ studies that the Resilience Project would have liked to do.

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Bermudagrass versus the armyworm

Scienmag

Striving for a better understanding of pest resistance in experimental lines Credit: Gurjit Singh Tifton, Georgia: A study out of the University of Georgia sought to determine the level of host plant resistance that can be assured by several promising experimental bermudagrass genotypes against potential damages committed by the fall armyworm.

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Enterprise Therapeutics’ First-in-Class TMEM16A potentiator program for treatment of cystic fibrosis and other respiratory diseases acquired by Roche

BioTech 365

Enterprise’s novel TMEM16A potentiator portfolio includes ETD002, a first in class compound which is currently in Phase 1 TMEM16A potentiation is a novel therapeutic approach applicable to all cystic fibrosis patients, independent of CFTR genotype, and may provide benefit in … Continue reading → Business Wire

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Forbion Portfolio Company, Enterprise Therapeutics’ First-in-Class TMEM16A Potentiator Program for Treatment of Cystic Fibrosis and Other Respiratory Diseases Acquired by Roche

BioTech 365

Enterprise’s novel TMEM16A potentiator portfolio includes ETD002, a first in class compound which is currently in Phase 1 TMEM16A potentiation is a novel therapeutic approach applicable to all cystic fibrosis patients, independent of genotype, and may provide benefit in other … Continue reading → Business Wire

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Enterprise Therapeutics Doses First Subjects in Phase 1 Trial for First-in-Class Cystic Fibrosis Therapy ETD002

BioTech 365

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New tool for identifying endangered corals could aid conservation efforts

Scienmag

Credit: Iliana Baums, Penn State Coral conservation efforts could get a boost from a newly developed genotyping “chip”–the first of its kind for corals.

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The power of similarities to accelerate antiviral development for COVID-19

Pharma R&D Today

As part of the few drugs available on the market, Boceprevir is a ketoamide-derived HCV NS3 protease inhibitor used to treat hepatitis caused by HCV genotype 1 and closely structurally related to PF-07321332, the antiviral developed by Pfizer for COVID-19.

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Inferring human genomes at a fraction of the cost promises to boost biomedical research

Scienmag

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies.

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#news #biotech Sensing what plants sense: Integrated framework helps scientists explain biology and predict crop performance

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Sensing what plants sense: Integrated framework helps scientists explain biology and predict crop performance.Scientists have invested great time and effort into making connections between a plant’s genotype, … Continue reading → #news

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Novel monoclonal antibody can substantially lower triglycerides in patients with acute pancreatitis

Scienmag

The fully human monoclonal antibody produced sustained reductions in triglyceride levels of up to 82 percent, depending on the patient’s genotype, while also lowering the […]. The investigational drug evinacumab reduced triglycerides in patients with severe hypertriglyceridemia (sHTG) and a history of hospitalizations for acute pancreatitis in a phase 2 global study led by Mount Sinai.

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Large-Scale Study Shows Guardant360 Liquid Biopsy Accelerates Clinical Trial Enrollment Compared to Tissue Biopsy

BioTech 365

Despite advances in precision oncology, progress is slowed by the limitations of tissue genotyping, … Continue reading → Business WireNature Medicine Publication Reports that Liquid Biopsy More Than Doubles Clinical Trial Enrollment Rate Compared to Tissue Biopsy REDWOOD CITY, Calif.–(BUSINESS –(BUSINESS WIRE)–Guardant Health, Inc. Nasdaq: GH).

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#news #biotech GTEx Consortium releases fresh insights into how DNA differences govern gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GTEx Consortium releases fresh insights into how DNA differences govern gene expression.Scientists from the Genotype-Tissue Expression (GTEx) project, a National Institutes of Health-funded consortium including researchers from … Continue reading → #news

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European Commission( EC) Approves LIVTENCITYTM ?( maribavir) for the Treatment of Grown-ups WithPost-transplant Cytomegalovirus( CMV) Infection And/ or complaint That Are Refractory( With or Without Resistance) to One or further previous curatives

The Pharma Data

It’s also approved by Health Canada for the treatment of grown-ups withpost-transplant cytomegalovirus( CMV) infection/ complaint who are refractory( with or without genotypic resistance) to one or further previous antiviral curatives.11 European Commission( EC) Approves LIVTENCITYTM ?(

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Evolution in Hepatitis B and C Virus: Can we expect success similar to Hepatitis C in Hepatitis B as well?

Delveinsight

Hepatitis C treatment options, without a doubt, have improved significantly, including pan-genotypic medications that are used to treat all genotypes and subtypes. Epclusa) was developed as the first drug therapy to treat all hepatitis C genotypes.

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Study adds to HRT and Alzheimer’s debate

Pharma Phorum

Their work specifically focused on the effect of HRT on women with the APOE4 genotype. Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK.

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Covid vaccine booster raises antibody levels in fight against Omicron

Pharma Phorum

The findings have been submitted to the Genotype-to-Phenotype National Virology Consortium (G2P-UK), the New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) and the Joint Committee on Vaccination and Immunisation (JCVI).

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Congenital fibrinogen deficiency market forecast to reach $800m across 3MM by 2031

Pharmaceutical Technology

Therefore, there is also a significant need for new therapies that target the underlying cause of CFD that may offer a cure for patients living with severe disease, or for patients with genotypes such as dysfibrinogenemia and hypodysfibrinogenemia, who are often ineligible for treatment with HFCs.

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How’s my driving? GPS tracking spots Alzheimer’s with 86% accuracy

Pharma Phorum

Adding in genotype testing for ApoE4 – a well-established diagnostic biomarker for Alzheimer’s pushed the accuracy of the diagnosis up, but only a little to 90%, showing that the GPS monitoring was remarkably effective on its own.

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EMA reviewing Novartis’ Adakveo after phase 3 miss

Pharma Phorum

for placebo, which is equivalent to a 45% reduction, regardless of sickle cell disease genotype or whether they were receiving hydroxyurea, a decades-old treatment for SCD.

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Bluebird trumpets long-term data from beta-thalassaemia gene therapy

Pharma Phorum

Davidson added: “Transfusion independence has been observed in paediatric, adolescent and adult patients and across genotypes – suggesting outcomes with this gene therapy may be consistent regardless of age or genotype.”.

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Can genetic data be a magic bullet for drug R&D?

Pharma Phorum

In terms of how the company operates, Auton stated that it currently has more than 13 million genotyped customers, 80% of whom consented for their health data to be used in research.

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How Pharmacogenomics may finally realise its promise

Pharma Phorum

The program is aiming to genotype roughly 150,000 participants over the next few years to demonstrate the impact personalised testing can have on a large scale. More than 60 percent of all American adults take prescription drugs , amounting to approximately 131 million individuals.

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Finding GRACE in a cancer diagnosis

Triage Cancer

Tissue Genotyping. Genotype directed therapies.

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EPA, DHA Intake From Fish May Reduce Childhood Asthma Risk

The Pharma Data

On stratification by FADS genotype, the odds ratio was 0.49 (95 percent confidence interval, 0.31 MONDAY, Feb.

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RSNA: Anxiety May Hasten Progression to Alzheimer Disease

The Pharma Data

WEDNESDAY, Nov.

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Genetics Tied to Thromboembolism Risk With Inflammatory Bowel Disease

The Pharma Data

from Cedars-Sinai Medical Center in Los Angeles, and colleagues used whole-exome sequencing and genome-wide genotyping to determine the proportion of 792 IBD patients genetically at risk for TED and investigate the effect of the genetic risk for TED in IBD. Professional.

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Novartis receives positive CHMP opinion for Pluvicto ® for cases with progressive, PSMA-positive metastatic castration- resistant prostate cancer

The Pharma Data

This differs from ‘ genotypic ’ perfection drug which targets specific inheritable differences in cancer cells10.

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Takeda Receives Positive CHMP Opinion for Maribavir for the Treatment of Adults with Post-transplant Cytomegalovirus (CMV) Refractory (With or Without Resistance) to Prior Therapies

The Pharma Data

Food and Drug Administration( FDA) blessing, under the brand name LIVTENCITYTM, for the treatment of grown-ups and pediatric cases( 12 times of age or aged and importing at least 35 kg) withpost-transplant cytomegalovirus( CMV) infection/ complaint that’s refractory to treatment( with or without genotypic resistance) with ganciclovir, valganciclovir, cidofovir, or foscarnet.