Scienmag

JULY 18, 2025

In a groundbreaking study that promises to redefine how we understand immune-mediated kidney disease, researchers have unveiled PathoPlex, a cutting-edge multiplexing technology that offers unprecedented insight into the cellular and molecular mechanisms driving renal pathology.

Antibody 90

Antibody In-Vivo In-Vitro Research 90

Scienmag

JUNE 17, 2025

The analysis of human clinical samples alongside in vitro and in vivo models strengthened the translatability of these findings, bridging the gap between bench and bedside. Persistent pulmonary hypertension of the newborn remains a significant clinical challenge, largely due to the incomplete grasp of its pathological mechanisms.

RNA 72

RNA Regulation DNA In-Vivo 72

Scienmag

JULY 4, 2025

Through a combination of transcriptomic analysis, chromatin immunoprecipitation sequencing, and in vivo tumor growth assays, the researchers meticulously charted the molecular consequences of HNF4α restoration. These interventions often provide only temporary relief and are frequently accompanied by severe side effects.

In-Vivo 59

In-Vivo Gene Gene Expression Research 59

Scienmag

JUNE 10, 2025

Cell lines often lose critical tumor-specific features through prolonged in vitro culture, but PDXs maintain the malignant phenotype in vivo, providing a more faithful and clinically relevant experimental framework. Despite their promise, PDX models confront substantial hurdles that have limited their widespread adoption.

Research 59

Research Clinical Trials Clinical Trials Gene Editing 59

Scienmag

JUNE 19, 2025

Complementary in vivo studies in animal models corroborated these findings, showing that the nanoparticles preferentially target malignant tissues, reducing off-target toxicity that often limits chemotherapeutic dosage in clinical settings. For decades, PLGA has been a stalwart in the fabrication of biodegradable nanoparticles.

Drug Delivery 72

Drug Delivery Drugs Drug Delivery Systems Protein 72

Scienmag

JUNE 23, 2025

The DNA barcodes can be activated and recorded in vivo in living mice, thereby preserving the natural developmental environment and avoiding the artifacts associated with in vitro studies. The essence of LoxCode lies in its ingenious use of DNA barcoding to uniquely mark each cell within a genetically engineered mouse.

In-Vivo 52

In-Vivo DNA Genetic Engineering Genetics 52

Scienmag

JULY 7, 2025

In the rapidly evolving field of genome editing, precision remains the cornerstone for advancing therapeutic potentials and broadening biological understanding. Among the myriad of tools developed, base editors (BEs) have emerged as transformative agents in enabling targeted nucleotide conversions without inducing double-strand breaks.

Genomics 59

Genomics Genome Genotype Engineer 59

XTalks

MAY 9, 2025

The ex vivo gene therapy involves harvesting a patients own skin cells, genetically modifying them in the lab to correct the COL7A1 mutation and then growing skin grafts that are transplanted back onto the patients wounds. Patients also suffer from scarring and increased risk of aggressive skin cancers.

Gene Therapy 90

Gene Therapy Gene FDA Approval Dermatology 90

Scienmag

JUNE 30, 2025

In the intricate workings of the brain, the circadian rhythm governs countless physiological processes, orchestrated by a complex interplay of molecular components. Among these, the transcription factor CLOCK has long been recognized as a crucial regulator, ubiquitously expressed across tissues to maintain robust circadian cycles. Fontenot, M.R.,

Gene Expression 80

Gene Expression Gene Regulation In-Vivo 80

Scienmag

JUNE 23, 2025

The seamless integration of the synthetic pathway within cellular metabolism ensures sufficient substrate availability and product flux, enabling sustained in vivo rearrangement over time. This unprecedented achievement, chronicled in the soon-to-be-published work by Johnson et al.

Engineer 52

Engineer In-Vivo Reagent Genetic Engineering 52

Scienmag

JULY 16, 2025

In a groundbreaking study published in Nature Microbiology , an international team of researchers led by Arzamasov, Rodionov, and Hibberd has unveiled unprecedented insights into the genetic and functional diversity of carbohydrate metabolism among human gut bifidobacteria.

Genomics 59

Genomics Genome Gene Bioinformatics 59

Scienmag

JULY 3, 2025

The researchers conducted meticulous in vivo and in vitro experiments demonstrating that binge alcohol exposure upregulates VGLUT3 expression in Kupffer cells. The liver is a vital organ responsible for detoxifying harmful substances, metabolizing drugs, and maintaining metabolic homeostasis.

In-Vivo 52

In-Vivo Genetics In-Vitro Gene Expression 52

Scienmag

JUNE 30, 2025

In the evolving landscape of biomedical materials, renewable polymers derived from natural sources have attracted significant scientific interest. The quest for sustainable and biocompatible materials has positioned polymers such as vegetable-derived cellulose, bacterial cellulose, chitosan, and starch at the forefront of cutting-edge research.

Medicine 87

Medicine Drug Delivery Systems Drug Delivery Production 87

Scienmag

JUNE 26, 2025

In vivo studies have pinpointed Purkinje cells and Golgi neurons within the cerebellum as the primary populations exhibiting elevated DNA damage upon cytarabine exposure. In the intricate landscape of neuronal biology, the epigenetic modifications of DNA play crucial yet often enigmatic roles.

DNA 59

DNA Genomics Genome Regulation 59

Scienmag

JULY 14, 2025

In the wake of successful tuberculosis (TB) treatment, a perplexing clinical challenge emerges: a subset of patients experience relentless and progressive lung damage that severely impairs respiratory function. It highlights not merely the immune cells but also structural and endothelial cells as active participants in disease perpetuation.

In-Vivo 59

In-Vivo Gene Expression Gene RNA 59

Scienmag

JUNE 24, 2025

In a groundbreaking advancement poised to redefine prenatal diagnostics, researchers are exploring the quantification of pulmonary T2 as a novel method to assess fetal lung status in cases of congenital diaphragmatic hernia (CDH). Despite advances in neonatal care, CDH remains a leading cause of neonatal morbidity and mortality worldwide.

In-Vivo 52

In-Vivo Development Medicine Research 52

Scienmag

JUNE 20, 2025

Recent research has delved deeper into how humeral rotation influences strain patterns and loading within the rotator cuff, revealing new insights that may have profound implications for understanding shoulder injuries and their rehabilitation.

In-Vitro 52

In-Vitro In-Vivo Research Engineer 52

Scienmag

JULY 3, 2025

The research employed a combination of in vivo murine models, human induced pluripotent stem cells (iPSCs), and novel epigenomic profiling techniques including chromatin immunoprecipitation sequencing (ChIP-seq) and single-cell RNA sequencing.

Genome 59

Genome Genomics Gene Regulation 59

Scienmag

JULY 2, 2025

The researchers utilized a comprehensive array of techniques including transcriptomic profiling, metabolomics, and in vivo muscle performance assays over multiple circadian phases. Rev-erbα is a transcriptional repressor involved in generating 24-hour rhythms by regulating clock gene transcription and metabolic genes.

Gene Expression 59

Gene Expression Gene Regulation In-Vivo 59

BioTech 365

JUNE 17, 2025

Zetagen Therapeutics Announces Peer-reviewed Publication of In-Vivo Dose Optimization Findings for ZetaMast™ (Zeta-MBC-005) for Triple Negative Breast Cancer Liver Metastases Zetagen Therapeutics Announces Peer-reviewed Publication of In-Vivo Dose Optimization Findings for ZetaMast™ (Zeta-MBC-005) for Triple Negative Breast Cancer Liver (..)

In-Vivo 40

In-Vivo 40

XTalks

NOVEMBER 29, 2024

This CD19-directed therapy generates CAR-T cells directly within the patient’s body, addressing the scalability challenges of traditional ex vivo approaches. The deal, valued at approximately $1 billion in upfront cash and up to an additional $500 million in milestone payments, is expected to close in the first quarter of 2025.

Gene Therapy 100

Gene Therapy Gene Gene Editing Genetic Engineering 100

Scienmag

JUNE 19, 2025

Organoids have surfaced as a transformative platform bridging the gap between two-dimensional cell cultures and in vivo tumor biology. The groundbreaking study, spearheaded by Nakano, K., Yamazaki, M., Such insights illuminate the adaptive reprogramming that equips these cells to endure recent cytotoxic stress.

In-Vivo 59

In-Vivo Research Gene Expression Genotype 59

Scienmag

JULY 9, 2025

Experimental induction of DNA damage in adipocyte progenitors using Etoposide recapitulated key in vivo stress responses, manifested by elevated stress marker proteins and a concomitant decline in differentiation capacity.

Gene Expression 59

Gene Expression Gene In-Vivo In-Vitro 59

Scienmag

JULY 3, 2025

In the relentless pursuit to decipher the molecular underpinnings of bladder cancer, a groundbreaking study has unveiled a pivotal role of the transcription factor TCF3 in orchestrating tumor progression through a novel ferroptosis-dependent pathway.

Regulation 59

Regulation Gene In-Vivo In-Vitro 59

Scienmag

JUNE 18, 2025

Delving into the methodology, probabilistic tractography leverages diffusion tensor imaging (DTI) to chart the probabilistic paths of water diffusion along axonal fibers, thus reconstructing white matter connectivity in vivo. These findings shed light on the neurodevelopmental trajectory of psychotic disorders.

In-Vivo 95

In-Vivo Genetics Research Genomics 95

BioTech 365

JUNE 12, 2025

Editas Medicine Reports Proprietary Targeted Lipid Nanoparticle Delivery in Non-Human Primates Enables In Vivo HBG1/2 Promoter Editing for Sickle Cell Disease and Beta Thalassemia at the European Hematology Association 2025 Congress in June Editas Medicine Reports Proprietary Targeted Lipid Nanoparticle … Continue reading →

In-Vivo 52

In-Vivo Medicine 52

Scienmag

JUNE 30, 2025

Importantly, the research employs both in vitro cell culture models and in vivo murine tumor xenografts to validate the relevance of SH3BGRL-mediated engulfment in cancer progression. However, mutations within the TP53 gene—a hallmark in a vast majority of human cancers—transform this protective sentinel into a driver of malignancy.

Protein 59

Protein Gene In-Vivo In-Vitro 59

Scienmag

JUNE 24, 2025

This invaluable resource enables researchers to culture organoids—miniature, three-dimensional fallopian tube models—that faithfully recapitulate in vivo tissue architecture and cellular interactions. Nagarajan Kannan, Ph.D., She notes, “Most high-grade ovarian cancers actually originate in the fallopian tube epithelium.

Clinical Research 59

Clinical Research Research Biobanking Genetics 59

Scienmag

JUNE 21, 2025

This study employed advanced molecular biology techniques alongside rigorous in vitro and in vivo models of NSCLC to map the Nrf2-HMOX1 axis’s function and its impact on cisplatin responsiveness. Cisplatin remains a cornerstone chemotherapeutic agent for NSCLC, yet its efficacy is severely limited by the rapid emergence of drug resistance.

Regulation 52

Regulation In-Vivo In-Vitro Research 52

Scienmag

JUNE 9, 2025

This detailed mimicry of phase separation dynamics in a synthetic system opens a window into understanding how ECM proteins modulate their assembly pathways in vivo, which has traditionally been difficult due to biological complexity and transient intermediate states.

Engineer 86

Engineer Protein In-Vivo In-Vitro 86

Scienmag

JUNE 25, 2025

In the relentless battle against glioblastoma (GBM), one of the deadliest primary brain cancers known to medicine, researchers have unveiled a groundbreaking method to decode the complex cellular conversations occurring within the tumor microenvironment.

Genetics 75

Genetics RNA In-Vivo Research 75

Scienmag

JUNE 30, 2025

In recent years, neurodegenerative disorders characterized by abnormal tau protein accumulation, collectively known as tauopathies, have posed a formidable challenge to biomedical research and clinical treatment. The study, conducted by Bar et al.,

Protein 72

Protein In-Vivo Research Genetics 72

Scienmag

JULY 14, 2025

Notably, no differences were observed in CCL22 production, a recruiter of regulatory T cells, across treatments, aligning with similar levels of immunosuppressive Treg infiltration in vivo. This revelation paves the path for innovative microbiota-driven immunotherapies that harness the body’s own cellular machinery to combat cancer.

Immune Response 59

Immune Response In-Vivo Gene Expression Production 59

Scienmag

JUNE 21, 2025

Importantly, the study utilises a combination of in vitro glioblastoma models, patient-derived cells, and in vivo murine systems to validate these findings. This unexpected duality challenges existing paradigms around cell death pathways in cancer and opens novel avenues for therapeutic intervention.

In-Vivo 72

In-Vivo In-Vitro Bioinformatics Research 72

Scienmag

JUNE 30, 2025

This depletion of hostility within a single person’s microbiome points to selection mechanisms that favor tolerance or mutual coexistence in vivo, thus ensuring a stable and functional microbial community. The variability in antimicrobial production and resistance among S.

Bacteria 59

Bacteria Genomics Genome In-Vivo 59

XTalks

NOVEMBER 25, 2024

XTALKS WEBINAR: Enhance Early Biomarker Discovery: Translating In Vitro and In Vivo Multi-Omics Oncology Data Live and On-Demand: Thursday, January 16, 2025, at 11am EST (4pm GMT/UK) Register for this free webinar to learn how to harness the full potential of multi-omics data and advanced patient models to drive early biomarker discovery.

FDA Approval 105

FDA Approval In-Vivo In-Vitro Drugs 105

Scienmag

JUNE 21, 2025

In a groundbreaking stride toward addressing the complex challenges posed by Fanconi anemia, a genetic disorder marked by progressive bone marrow failure and cancer susceptibility, researchers have unveiled novel therapeutic agents that promise to fundamentally alter treatment landscapes.

Drugs 59

Drugs Genetics Protein DNA 59