Intellia, Regeneron ace first trial with ‘in vivo’ CRISPR drug

Pharma Phorum

The first ever clinical data with a CRISPR/Cas9 drug used to edit the genomes of cells within the body has yielded impressive results in patients with ATTR amyloidosis, a life-threatening rare disease. . In three more patients treated at 0.1mg/kg levels fell by 52%.

Ixaka to present in vivo gene delivery platform for CAR-T and related bioproduction challenges at 6th CAR TCR Summit

BioTech 365

Ixaka to present in vivo gene delivery platform for CAR-T and related bioproduction challenges at 6th CAR TCR Summit Ixaka to present in vivo gene delivery platform for CAR-T and related bioproduction challenges at 6th CAR TCR Summit CSO, Cecile … Continue reading → Business Wire

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Precision BioSciences to Host In Vivo Gene Editing R&D Event on September 9, 2021

BioTech 365

Precision BioSciences to Host In Vivo Gene Editing R&D Event on September 9, 2021 Precision BioSciences to Host In Vivo Gene Editing R&D Event on September 9, 2021 DURHAM, N.C.–(BUSINESS –(BUSINESS WIRE)–Precision BioSciences, Inc. Nasdaq: DTIL), a clinical stage biotechnology company … Continue reading → Business Wire

Neurons in spinal-cord injuries are reconnected in vivo via carbon nanotube sponges

Scienmag

Editas Sees Light in First Data from In Vivo CRISPR Eye Therapy

BioSpace

EDIT-101 targets a disease-causing mutation in the CEP290 gene that causes degeneration in ocular photoreceptor cells, which are critical for normal vision

Nimbus Therapeutics Presents In Vivo Data Showing Single-Agent and Combination Activity of HPK1 Inhibitor

BioTech 365

Nimbus Therapeutics Presents In Vivo Data Showing Single-Agent and Combination Activity of HPK1 Inhibitor Nimbus Therapeutics Presents In Vivo Data Showing Single-Agent and Combination Activity of HPK1 Inhibitor CAMBRIDGE, Mass.–(BUSINESS

LIfT BioSciences N-LIfT Cell Therapy Successfully Infiltrates Pancreatic Tumours In-vivo

BioTech 365

New microrobot with in situ, in vivo bioprinting offers promise for gastric wounds

Scienmag

Researchers in China have taken the first step towards a new way of treating gastric wounds by using a microrobot combined with the new concept of “in situ in vivo bioprinting” to carry out tissue repair inside the body. Their study, published today in the IOP Publishing journal Biofabrication, establishes proof-of-concept for this new method […].

Medicine of the Future Happening Today - Seelos Sees Promise for In Vivo Gene Editing

BioSpace

This appears to be a second example of CRISPR gene editing inside the body, as opposed to in cell cultures

CorWave Presents an Unprecedented Chronic In Vivo Study at the 41st Annual Meeting of the International Society of Heart and Lung Transplantation

BioTech 365

CorWave Presents an Unprecedented Chronic In Vivo Study at the 41st Annual Meeting of the International Society of Heart and Lung Transplantation CorWave Presents an Unprecedented Chronic In Vivo Study at the 41st Annual Meeting of the International Society of … Continue reading → Business Wire

Synaffix Sees Competitive Early In Vivo Data from ADCs Based on Proprietary Exatecan Linker-Payload

BioTech 365

In vivo efficacy on a par with gold standard deruxtecan-based ADCs Poster to be presented at World ADC meeting on 17 September 2020 AMSTERDAM–(BUSINESS WIRE)–Synaffix B.V.,

#news #biotech Sanofi pays $160M for mRNA tech to reprogram T cells in vivo

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Sanofi pays $160M for mRNA tech to reprogram T cells in vivo.Sanofi pays $160M for mRNA tech to reprogram T cells in vivo ntaylor Mon, 04/12/2021 – … Continue reading → #news

Researchers overcome translational gap by developing novel in vivo model for the labeling of insulin secretory granule pools

Scienmag

Furthermore, the current understanding of beta cell function is mostly derived from studies of ex vivo isolated islets in rodent […]. Biology developing gap granule insulin labeling model overcome pools researchers secretory translational vivo

Draper’s Tumor-on-a-Chip Parallels In Vivo Findings of Checkpoint Inhibitor Efficacy in Mice

BioSpace

Draper, in one of the latest lab-on-a-chip advances, has shown that its dynamic, in vitro tumor microenvironment can be used to distinguish tumor responses against two different checkpoint inhibitors in three mouse lines

Intellia Establishes Proof-of-Concept for in vivo CRISPR Bone Marrow Editing

BioSpace

Intellia Therapeutics presented preclinical data of its non-viral genome editing platform at the Keystone eSymposium: Precision Engineering of the Genome, Epigenome and Transcriptome

Positive preclinical in vivo results with AFFiRiS’ antibody mAB C6-17 to treat Huntington’s disease to be presented at the 16th Annual Huntington’s Disease Therapeutics Conference

BioTech 365

Positive preclinical in vivo results with AFFiRiS’ antibody mAB C6-17 to treat Huntington’s disease to be presented at the 16th Annual Huntington’s Disease Therapeutics Conference Positive preclinical in vivo results with AFFiRiS’ antibody mAB C6-17 to treat Huntington’s disease to … Continue reading → GlobeNewswire

Theratechnologies Presents New In Vivo Pre-Clinical Data at AACR Demonstrating Significant Anti-Tumor Activity of TH1902 in All Studied Cancer Types

BioTech 365

Theratechnologies Presents New In Vivo Pre-Clinical Data at AACR Demonstrating Significant Anti-Tumor Activity of TH1902 in All Studied Cancer Types Theratechnologies Presents New In Vivo Pre-Clinical Data at AACR Demonstrating Significant Anti-Tumor Activity of TH1902 in All Studied Cancer Types … Continue reading → GlobeNewswire

New Preclinical Data Presented at the 2021 American Society of Genetic & Cell Therapy Annual Meeting Highlights Precision BioSciences’ ARCUS In Vivo Genome Editing

BioTech 365

New Preclinical Data Presented at the 2021 American Society of Genetic & Cell Therapy Annual Meeting Highlights Precision BioSciences’ ARCUS In Vivo Genome Editing New Preclinical Data Presented at the 2021 American Society of Genetic & Cell Therapy Annual Meeting … Continue reading → Business Wire

Novel Biological Cell Signaling Tech Enables IoT-Like Control of Cell Function in Vivo

BioSpace

A novel way to control biologic signaling allows cellular function to be modulated via cell phone, according to research presented at the American Chemical Society’s annual meeting Tuesday by researchers at the University of Maryland

Beyond Air® Presents In Vivo Solid Tumor Data Confirming In Situ Cancer Vaccination with a Single Injection of Gaseous Nitric Oxide at the AACR Conference on Tumor Immunology and Immunotherapy

BioTech 365

New in vivo data for colon cancer show anti-tumor immunity in 100% of mice In vivo breast cancer data show a significant delay in challenge tumor uptake GARDEN CITY, N.Y., 19, 2020 (GLOBE NEWSWIRE) — Beyond Air, Inc. NASDAQ: … Continue reading → GlobeNewswire

Intellia, beginning treatment in CRISPR study, secures Gates Foundation backing

Bio Pharma Dive

The biotech won a grant from the foundation two days after dosing the first patient in a study of an in vivo CRISPR medicine, a milestone for the company and the technology

Editas Medicine to Present Preclinical Data Demonstrating Advancements in In Vivo Gene Editing Approach for the Treatment of Genetic Ocular Diseases at the Association for Research in Vision and Ophthalmology Annual Meeting

BioTech 365

Editas Medicine to Present Preclinical Data Demonstrating Advancements in In Vivo Gene Editing Approach for the Treatment of Genetic Ocular Diseases at the Association for Research in Vision and Ophthalmology Annual Meeting Editas Medicine to Present Preclinical Data Demonstrating Advancements … Continue reading → GlobeNewswire

Preclinical Data on New Pancreatic Cancer Drug Shines with over 90% Efficacy

BioSpace

Preclinical data for its drug candidate, LP-184, reportedly showed over 90 percent efficacy in shrinking pancreatic cancer tumors in mouse models in vitro, in-vivo, and ex-vivo

Pfizer, BioNTech’s COVID-19 vaccine likely to be effective against UK strain

Pharma Times

Antibodies in blood of vaccinated individuals neutralised in vivo version of variant

Biotech Company Driven by Cutting Edge Science and Patients, Not Ego

BioSpace

On June 26, Intellia announced the first-ever clinical data supporting the safety and efficacy of in vivo CRISPR genome editing in human patients

NanoMab receives MHRA approval to commence a Phase 2 Clinical Study to investigate PD-L1 expression using its NM-01 product as a tool for non-invasive in vivo imaging.

Drug Discovery Today

London, November 4th, 2020: NanoMab Technology Limited, a privately held biopharmaceutical company focussing on cancer precision therapies, today announced that it had received CTA Acceptance from the Medicines Healthcare products Regulatory Agency (MHRA) to carry out a Phase II clinical Study for its NM-01 product

A Pivotal Moment for CRISPR in the Gene Editing Journey

BioSpace

With this milestone, the field is now wide open for the next in vivo CRISPR success, and Editas is hoping that it will be in the ocular disease space

Mispro’s Emerging Business Model Helps Biopharma Companies Get to Market Faster

BioSpace

This model has the benefit of giving companies direct oversight of their in vivo studies, allowing them to move faster while operationalizing every dollar of their seed financing

Sorrento Announces the Closing of Its Acquisition of SmartPharm to Build Next Generation G-MAB-Encoded Plasmid DNA For Cost-Efficient and In Vivo Production of Antibody Therapeutics in Patients

BioTech 365

SAN DIEGO and BOSTON, Sept. 02, 2020 (GLOBE NEWSWIRE) — Sorrento Therapeutics, Inc. Nasdaq: SRNE, “Sorrento”) and SmartPharm Therapeutics, Inc. (“SmartPharm”) announced today that Sorrento has completed the acquisition of SmartPharm, a gene-encoded protein therapeutics company developing non-viral DNA and … Continue reading → GlobeNewswire

Celltrion: COVID-19 antibody treatment effective against Delta variant

BioPharma Reporter

Celltrion Group has reported that data from an in vivo efficacy study shows that its monoclonal antibody treatment for COVID-19, regdanvimab (CT-P59), has a strong neutralizing effect against the rapidly spreading Delta variant.

First observation of the early link between proteins linked to Alzheimer’s disease

Scienmag

These results will help researchers to identify at an early stage the people most at risk of developing the disease, well before the first cognitive symptoms appear Credit: ©ULiège/CRC In Vivo Imaging Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the […].

Cancer: Information theory to fight resistance to treatments

Scienmag

Researchers from the UNIGE and the HUG have used information theory for the first time to monitor in vivo the development of resistance mechanisms to a cancer-targeted therapy.

Integrative analyses revealed the roles of G6PD in cisplatin resistance via redox system

Scienmag

Niigata and Tokyo, Japan – Three-dimensional (3D) culturing approaches help probe cancer stem-like cells (CSCs)-associated traits, chemoresistance, and cellular heterogeneity ex vivo.

Sanofi gains mRNA immunotherapy platform with Tidal Therapeutics acquisition

BioPharma Reporter

Sanofi has acquired Cambridge, Massachusetts biotech Tidal Therapeutics: gaining its novel mRNA-based approach for in vivo reprogramming of immune cells.

CAR T therapy focused Umoja hits manufacturing capability linked milestone

BioPharma Reporter

Seattle-based Umoja Biopharma, a company looking to reprogram immune cells in-vivo to create next-generation immunotherapies for the treatment of solid tumors and hematologic malignancies, has started work on its new development and manufacturing facility in Colorado.

Martin Borch Jensen to present at the 8th Aging Research & Drug Discovery Meeting 2021

Scienmag

Martin Borch Jensen to present new research in the biology of aging at the world’s largest aging research for drug discovery conference Credit: Insilico Medicine Hong Kong Limited Wednesday, June 23, 2021, London — Martin Borch Jensen, PhD.,

iECURE Appoints Brian Di Donato to Board of Directors

BioTech 365

iECURE Appoints Brian Di Donato to Board of Directors iECURE Appoints Brian Di Donato to Board of Directors PHILADELPHIA–(BUSINESS WIRE)–iECURE, a mutation-agnostic in vivo gene editing company striving to cure devastating diseases with high unmet need, today announced it has … Continue reading → Business Wire

Nectero Medical Completes $19.5 Million Series C Financing

BioTech 365

Million Series C Financing Proceeds from new investors will fund in vivo and clinical development of innovative platform for aneurysmal disease, including Abdominal Aortic Aneurysms (AAA) TEMPE, Ariz.–(BUSINESS Nectero Medical Completes $19.5

Oncotarget: mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC

Scienmag

Oncotarget published “High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC” which reported that the aim of […].

NKarta Therapeutics’ NKT Cells Elicit Better Response than CAR-T Cells Alone

BioSpace

NKarta Therapeutics is using engineered chimeric antigen receptor natural killer T cells (CAR-NKT cells) for allogeneic therapy, showing substantial benefits both in vitro and in vivo, according to James Trager, CSO, speaking Wednesday at the virtual CAR-TCR Summit – Europe

Biosensors monitor plant well-being in real time

Scienmag

Diurnal in vivo xylem sap glucose and sucrose monitoring using implantable organic electrochemical transistor sensors Credit: Thor Balkhed Researchers at Linköping University, Sweden, have developed biosensors that make it possible to monitor sugar levels in real time deep in the plant tissues – something that has previously been impossible.

Smectite promotes probiotic biofilm formation in gut for cancer immunotherapy

Scienmag

Credit: Lei Dong, Nanjing University Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice.

First non-human primate study showing promise of gene therapy for stroke repair

Scienmag

Gong Chen at Jinan University, Guangzhou, China recently reported the first non-human primate study demonstrating successful in vivo neural regeneration from brain internal glial cells for stroke repair.