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‘In vivo’ cell therapy: expanding beyond CAR-T

Bio Pharma Dive

At least five startups have emerged with new ways to genetically modify immune cells within the body, an approach that, if successful, could widen the field of CAR-T treatment.

In-Vivo 359
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Interius Gets Go-Ahead for Phase I Trial of In Vivo CAR-T Therapy in Australia

BioSpace

Interius BioTherapeutics has received approval from Australia’s Human Research Ethics Committee to begin the first-in-human trial of an investigational in vivo CAR-T therapy designed to treat B-cell malignancies.

In-Vivo 74
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3rd In Vivo Cell Engineering & Gene Editing Summit

pharmaphorum

Achieve Safe & Targeted In Vivo Delivery of Payloads with Clarity in Regulations & Appropriate Models to Advance the Next Frontier of In Vivo Editing from Research to Clinic

In-Vivo 52
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$175M financing will support development of in vivo CAR-T therapies

Drug Discovery World

The proceeds will be used to advance CPTX2309, Capstan’s lead in vivo chimeric antigen receptor T cell (CAR-T) candidate, to early clinical proof-of-concept in autoimmune disorders, and to further develop Capstan’s tLNP pipeline. Biotechnology company Capstan Therapeutics has raised $175 million in an oversubscribed Series B financing.

In-Vivo 52
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Astellas teams up with startup Kelonia to make ‘in vivo’ cell therapies

Bio Pharma Dive

Kelonia will receive $40 million upfront through a partnership to develop “off-the-shelf” cell therapies for cancer.

In-Vivo 298
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The in vivo tool enabling a confident transition to Phase I trials

Drug Discovery World

The post The in vivo tool enabling a confident transition to Phase I trials appeared first on Drug Discovery World (DDW). Download the latest whitepaper to learn more about: The importance of selecting appropriate starting doses in clinical trials. Why humanised mice better predict human responses to therapeutics.

In-Vivo 52
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€30m raised for first-in-class in vivo cell reprogramming platform

Drug Discovery World

The therapy has achieved preclinical proof of concept (PoC) in patient-derived ex vivo models as well as rodent in vivo models, inducing strong anti-tumour immunity and abscopal effect, even in a monotherapy setting. We believe this breakthrough strategy will give rise to the next generation of cell therapies.

In-Vivo 52