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In Vivo Mapping of Human Enhancer Mutagenesis

Scienmag

In a groundbreaking new study, scientists have unveiled a comprehensive map detailing the mutagenesis sensitivity of human developmental enhancers in vivo, shedding unprecedented light on the intricate sequence architecture that governs gene regulation during human development.

In-Vivo 80
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Innovative Technique Allows In Vivo Creation of CAR T Cells for Cancer and Autoimmune Disease Treatment

Scienmag

This novel strategy circumvents the traditional, labor-intensive ex vivo manufacturing processes by enabling the generation of CAR T cells directly within the patient’s body. The reliance on ex vivo manipulation also exposes cells to potential contamination, and manufacturing variability can impact therapeutic efficacy.

In-Vivo 52
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AbbVie to buy CAR-T developer Capstan in deal worth up to $2.1B

Bio Pharma Dive

The acquisition will expand AbbVie's exploration of in vivo CAR-T therapy, an ambitious approach that could sidestep some of the difficulties presented by current cell treatments.

In-Vivo 141
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Insights into Brain Tumor Growth Patterns Could Enhance Patient Care Strategies

Scienmag

Untangling the complexities of how mechanical stress impacts the brain has posed challenges historically, limited by the difficulty of adequately measuring these forces in vivo during surgery and correlating them with clinical outcomes. Funded by prominent bodies such as the National Institutes of Health and the U.S.

In-Vivo 59
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Near-Infrared Activated Chemically Induced CRISPR

Scienmag

Such capability paves the way for in vivo applications, allowing clinicians to trigger gene editing in hard-to-reach tissues or organs without surgical incisions. Upon activation, this inducer triggers the assembly or functionalization of CRISPR-Cas components, thereby enabling genomic editing activities precisely where and when desired.

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Engineered Aligned Stem Cell Sheets Advance Regenerative Medicine Therapies

Scienmag

This synergy enhances the overall biological performance of the stem cell constructs, potentially translating into superior regenerative capacity in vivo. These biochemical signals are critical mediators in the healing cascade, often determining the success of regenerative therapies.

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Triggering Bacterial Calcification to Combat MRSA

Scienmag

In vivo experiments demonstrated that bacterial calcification stimulates the upregulation of calprotectin proteins—specifically S100A8 and S100A9—in macrophages and monocytes. Its notorious ability to evade conventional antimicrobials has fueled severe infections that are increasingly difficult to treat with existing therapies.