China-based biotech licenses Sanofi's RNA drug technology

Bio Pharma Dive

The Lilly-backed Rona Therapeutics gains rights to a platform for small interfering RNA, along with a slate of preclinical candidates aimed at targets in the liver and other tissues

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Amgen partners with Arrakis to develop drugs aimed at RNA

Bio Pharma Dive

Arrakis, a specialist in designing oral drugs that target RNA, will receive $75 million under the deal, which could be worth "several billion dollars" more

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Hallmark cancer gene regulates RNA ‘dark matter’

Scienmag

A key genetic mutation that occurs early on in cancer alters RNA “dark matter” and causes the release of previously unknown RNA biomarkers for cancer early detection, a new study by UC Santa Cruz researchers published in the journal Cell Reports shows. Cancer cancer dark gene Hallmark matter regulates RNA

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J&J to explore RNA reprogramming with Remix research deal

Bio Pharma Dive

The agreement with the Cambridge-based startup is the latest to reflect growing large pharma company interest in targeting RNA with small molecules

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Moderna founder unveils new drug company focused on a different kind of RNA

Bio Pharma Dive

The biotech is researching how to make medicines from transfer RNA molecules Encouraged by Moderna's success, Flagship Pioneering has been busy creating startups like Alltrna, which launched Tuesday.

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Messenger RNA technology shows promise for developing infectious disease therapeutics

Scienmag

Army scientists and industry partners were among the first to demonstrate that messenger RNA (mRNA)—the technology recently used in COVID-19 vaccines and others—could also be used to develop treatments for infectious diseases.

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Moderna founder launches new biotech, looking to cure diseases through 'endless RNA'

Bio Pharma Dive

Laronde comes equipped with $50 million in funding from Flagship Pioneering and a goal to upend how diseases are treated with long-lasting RNA medicines

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UTSW study: RNA exosome key for B cell development

Scienmag

New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system’s ability to protect against infection.

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Merck makes circular RNA play with $3.5bn Orna alliance

pharmaphorum

Merck & Co has ramped up its involvement in the RNA category, partnering with US biotech Orna Therapeutics in a deal valued at up to $3.5 Now, Merck has made its own play, partnering with Orna on its proprietary ‘oRNA’ technology, which stands for circular RNA.

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Double-stranded RNA induces bone loss during gum disease

Scienmag

They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone. Medicine & Health bone Disease Doublestranded gum induces loss RNA

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Single cell RNA sequencing uncovers new mechanisms of heart disease

Scienmag

Biology cell Disease heart mechanisms RNA sequencing single uncoversHypertrophic cardiomyopathy is a heart disease that leads to a stressed, swollen heart muscle. Due to a poor understanding of underlying mechanisms, effective clinical treatments are not available.

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???????Research sheds light on mysterious messenger RNA modifications

Scienmag

A team led by scientists at the University of Birmingham has come a step closer to uncovering the purpose of a distinctive set of modifications found at the beginning of messenger RNA which have long remained a fundamental mystery in molecular biology.

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Venture capital pours more money into RNA medicines with the launch of Replicate

Bio Pharma Dive

The company, which focuses on self-replicating RNA, comes equipped with $40 million from Apple Tree Partners and a stamp of approval from the former research head at Biogen

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Next Generation RNA Therapeutics Summit

Pharma Phorum

Are you looking to solve challenges with current RNA therapeutics, such as the degradation of RNA by RNAses, the difficulty of RNA crossing the cell membrane by diffusion and the immunogenicity elicited by exogenous RNA? Next generation RNA therapeutics can help!

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Moderna founder's next big play in RNA raises $440 million

Bio Pharma Dive

Just a few months out of stealth mode, Laronde and its "endless RNA" technology have caught the attention of well-known investors like Fidelity, T. Rowe Price Associates and Invus

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Roche adds to RNA drug deal streak with Ribometrix partnership

Bio Pharma Dive

The companies' pact is the latest addition to a growing list of deals involving startups developing chemical drugs to target RNA molecules

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New analysis reveals ecological patterns and roles of marine RNA viruses

Scienmag

Community- and “species”-level analysis on Global Ocean RNA sequences sampled from waters worldwide has shed light on the poorly understood diversity and ecological footprint of marine RNA viruses, according to a new report. The findings underscore the important roles marine RNA viruses play in the ocean ecosystem. Latest News analysis ecological Marine Patterns reveals RNA roles viruses

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Eli Lilly Pursues RNA Editing in New Partnership with ProQR

XTalks

billion deal will see the companies use ProQR’s proprietary Axiomer RNA editing platform technology to advance editing oligonucleotide-based therapeutics toward clinical development and commercialization.

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COVID-19 : Measuring viral RNA to predict which patients will die

Scienmag

Credit: CHUM The amount of a SARS-CoV-2 genetic material—viral RNA—in the blood is a reliable indicator in detecting which patients will die of the disease, a team led by Université de Montréal medical professor Dr.?Daniel Medicine & Health COVID19 die Measuring Patients predict RNA vira

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RNA Therapeutics 2022

Pharma Phorum

SMi Group’s 13th Annual Conference: RNA Therapeutics 2022. Bolstering the latest advances and opportunities in RNA-based medicine. Delve into the latest innovations in novel RNA delivery and target specificity. Head of RNA Biology.

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With Cryo-EM, Sloan Kettering Institute scientists determine structure of key factor in RNA quality control

Scienmag

Biology control cryoEM determine factor Institute Kettering key quality RNA scientists Sloan structureNEW YORK, JUNE 9, 2022 – In biology, getting rid of stuff can be just as important as making it.

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HKUST researchers reveal RNA elements that enhance the cleavage of pre-miRNAs/shRNAs by DICER

Scienmag

Biology cleavage DICER elements enhance HKUST premiRNAsshRNAs researchers reveal RNA

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New open-source software automates RNA analysis to speed up research and drug development

Scienmag

LA JOLLA, CA—Scientists at Scripps Research have unveiled a new software tool for studying RNA (ribonucleic acid) molecules, which have a host of critical roles in organisms. Latest News analysis automates development Drug opensource research RNA software speed

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RNA-Dependent RNA Polymerase (RdRP or RNA Replicase) Inhibitor Drug Pipeline Market Research Report 2022 – ResearchAndMarkets.com

BioTech 365

RNA-Dependent RNA Polymerase (RdRP or RNA Replicase) Inhibitor Drug Pipeline Market Research Report 2022 – ResearchAndMarkets.com RNA-Dependent RNA Polymerase (RdRP or RNA Replicase) Inhibitor Drug Pipeline Market Research Report 2022 – ResearchAndMarkets.com DUBLIN–(BUSINESS WIRE)–The “RNA-Dependent RNA Polymerase (RdRP or RNA … Continue reading → Business Wire

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RNA molecules control repair of human DNA in cancer cells

Scienmag

A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to better cancer treatments. It was long assumed that RNA molecules – basic molecules that exist […]. Latest News cancer cells control DNA human molecules repair RNA

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Lilly joins RNA editing race with ProQR deal

Bio Pharma Dive

An agreement with the Dutch biotech, which could be worth as much as $1.3 billion, expands Lilly's work in genetic medicine research

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Novel, sensitive, and robust single-cell RNA sequencing technique outperforms competition

Scienmag

The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized the fields of medicine and biology by providing the ability to study the inner workings of thousands of cells at one go. Social & Behavioral Science competition outperforms RNA robust sensitive sequencing Singlecell technique

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Merck pays startup Orna $150M as ‘circular RNA’ attracts industry interest

Bio Pharma Dive

The pharmaceutical company has formed an alliance with Orna and invested $100 million in its Series B round, hoping the young biotech’s approach could lead to multiple new vaccines and drugs

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BioTuring enters collaboration to enable detailed single-cell RNA research

Pharma Phorum

The collaboration aims to “close the gap between single-cell RNA sequencing wet-lab services and single-cell data analysis solutions,” which will allow scientists to study the finest details that can be hard to access. News R&D pharma rna rna therapeutics Single Cell Analysis

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How RNA-Based Pesticides Can Improve Pest Control

XTalks

Perhaps popularized by the COVID-19 vaccines, RNA-based technologies now have the potential to become the next best pesticide to combat crop pests, like insects and fungal pathogens. What are RNA-Based Pesticides? Advantages of RNA-Based Pesticides.

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GSK dives into NASH, RNA interference with Arrowhead deal

Bio Pharma Dive

GSK has secured rights to a genetic medicine in early-stage human testing for NASH, a disease thought to affect millions of people and which has proven to be a tough target for drugmakers

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CAMP4 raises $100m to take lead RNA drugs into clinic

pharmaphorum

Armed with a $100 million second-round financing, CAMP4 Therapeutics is preparing to start the first clinical trial of a drug targeting regulatory RNA (regRNA) molecules that can be used to fine-tune the expression of genes.

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RNA Therapeutics Experience Renaissance Amidst Global Pandemic

BioSpace

RNA caught the public’s imagination in the form of mRNA vaccines against COVID-19, but RNA can be used in other ways, too, to make therapeutic proteins

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Alnylam Files Lawsuits Against Pfizer and Moderna Over Patent Infringement of RNA Delivery Technology

XTalks

Credited as a pioneering RNA interference (RNAi) therapeutics company, Alnylam Pharmaceuticals is taking Pfizer and Moderna to court, claiming that the companies’ use of the lipid nanoparticle (LNP)-based RNA delivery technology in their mRNA COVID-19 vaccines infringes on a patented technology.

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Lucerna is Illuminating the Mysteries of RNA to Solve Disease

BioSpace

The company aims to make RNA molecules visible and druggable – opening the door to study RNA-based diseases

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Peanut studies reveal surprising truths about RNA and open the door to better understanding epigenetic mechanisms in plants

Scienmag

Medicine & Health door epigenetic mechanisms open Peanut plants reveal RNA Studies surprising truths UnderstandingPlants encounter microbes all the time, in the air, water, and soil. Some cause disease, others are neutral, but a few microbes promote plant health and growth.

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Quantabio Launches Ultra-Fast RNA Library Prep Kit with Integrated Ribosomal RNA and Globin Depletion for Precision Oncology Applications

BioTech 365

Quantabio Launches Ultra-Fast RNA Library Prep Kit with Integrated Ribosomal RNA and Globin Depletion for Precision Oncology Applications Quantabio Launches Ultra-Fast RNA Library Prep Kit with Integrated Ribosomal RNA and Globin Depletion for Precision Oncology Applications sparQ RNA-Seq HMR Kit … Continue reading → Business Wire

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Regulating the ribosomal RNA production line

Scienmag

coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].

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RNA modification may protect against liver disease

Scienmag

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2nd RNA Editing Summit 2020

Pharma Phorum

The only industry-led meeting showcasing the recent development of RNA editing mechanisms and dedicated to realizing the research and therapeutics opportunity of RNA editing as quickly as possible. The post 2nd RNA Editing Summit 2020 appeared first on.

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CAMP4’s funding influx paves the way for tapping regulatory RNA to treat urea cycle disorders

Pharmaceutical Technology

Last week, CAMP4 Therapeutics announced the close of a $100 million Series B round , which will be used to advance their regulatory RNA (regRNA)-focused programs. In order to find the specific RNA sequences for a genetic disease, the biotech is using an AI- and machine learning-based approach.

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Pushing Beyond Gene Editing Limits with Programmable RNA Medicines

BioSpace

Shape Therapeutics is evolving programmable RNA medicines that push the limits of current gene editing capabilities. BioSpace spoke with CSO David Huss

Lilly buys into MiNA’s protein-boosting RNA tech in $1.25bn deal

Pharma Phorum

UK biotech MiNA Therapeutics has signed up another big pharma partner for its small activating RNA (saRNA) platform, which upregulates the activity of proteins, with Eli Lilly the latest to get in on the action. . News R&D Eli Lilly MiNA Therapeutics partnering rna RNA-based drugs

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