Drugging RNA with pills: small molecules for a big frontier
Bio Pharma Dive
SEPTEMBER 6, 2022
A handful of startups have formed in recent years with plans to target RNA with small molecules. Many have caught the attention of big drugmakers
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Next-generation RNA technologies: making longer-lasting drugs with a broader reach
Bio Pharma Dive
AUGUST 23, 2022
At least 10 biotechnology startups are trying to use RNA molecules in new ways to make medicines. Here’s a look at where they stand
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China-based biotech licenses Sanofi's RNA drug technology
Bio Pharma Dive
JULY 25, 2022
The Lilly-backed Rona Therapeutics gains rights to a platform for small interfering RNA, along with a slate of preclinical candidates aimed at targets in the liver and other tissues
Ascidian starts up with $50M and a twist on RNA editing
Bio Pharma Dive
OCTOBER 12, 2022
The startup, run by Translate Bio cofounder Romesh Subramanian, believes its RNA “exon editing” approach could have long-lasting effects without the risks that come with editing DNA
Amgen partners with Arrakis to develop drugs aimed at RNA
Bio Pharma Dive
JANUARY 11, 2022
Arrakis, a specialist in designing oral drugs that target RNA, will receive $75 million under the deal, which could be worth "several billion dollars" more
Beam-linked startup launches with an eye on the next generation of RNA drugs
Bio Pharma Dive
SEPTEMBER 7, 2022
“We see a huge opportunity in the setting of RNA-based therapies to overcome some of the shortcomings that have been there with the first generation of RNA companies,” said former Alnylam CEO and Orbital Therapeutics co-founder John Maraganore
AstraZeneca gives up on Ionis’ RNA drug for heart disease
Bio Pharma Dive
SEPTEMBER 23, 2022
The British drugmaker decided the medicine, which works similarly to Novartis’s Leqvio, wasn’t potent enough to justify further testing
Moderna founder unveils new drug company focused on a different kind of RNA
Bio Pharma Dive
NOVEMBER 9, 2021
The biotech is researching how to make medicines from transfer RNA molecules Encouraged by Moderna's success, Flagship Pioneering has been busy creating startups like Alltrna, which launched Tuesday.
Moderna founder launches new biotech, looking to cure diseases through 'endless RNA'
Bio Pharma Dive
MAY 10, 2021
Laronde comes equipped with $50 million in funding from Flagship Pioneering and a goal to upend how diseases are treated with long-lasting RNA medicines
Hallmark cancer gene regulates RNA ‘dark matter’
Scienmag
JULY 19, 2022
A key genetic mutation that occurs early on in cancer alters RNA “dark matter” and causes the release of previously unknown RNA biomarkers for cancer early detection, a new study by UC Santa Cruz researchers published in the journal Cell Reports shows. Cancer cancer dark gene Hallmark matter regulates RNA
14th Annual RNA Therapeutics Conference
Pharma Phorum
NOVEMBER 1, 2022
14th Annual RNA Therapeutics. Investigating the next generation of genetic medicine through RNA based therapies. This is reflected with the value of the global antisense & RNA therapeutics market expected to reach USD 1.81 Who should attend: Directors of novel RNA therapies.
As Arrowhead falters, lungs remain a tough target for RNA drugs
Bio Pharma Dive
JULY 6, 2021
The biotech's decision to pause testing of a cystic fibrosis drug is the latest reminder of the difficulty of delivering RNA medicines into the lungs
Messenger RNA technology shows promise for developing infectious disease therapeutics
Scienmag
JULY 6, 2022
Army scientists and industry partners were among the first to demonstrate that messenger RNA (mRNA)—the technology recently used in COVID-19 vaccines and others—could also be used to develop treatments for infectious diseases.
Merck makes circular RNA play with $3.5bn Orna alliance
Pharma Phorum
AUGUST 16, 2022
Merck & Co has ramped up its involvement in the RNA category, partnering with US biotech Orna Therapeutics in a deal valued at up to $3.5 Now, Merck has made its own play, partnering with Orna on its proprietary ‘oRNA’ technology, which stands for circular RNA.
UTSW study: RNA exosome key for B cell development
Scienmag
JUNE 13, 2022
New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system’s ability to protect against infection.
Double-stranded RNA induces bone loss during gum disease
Scienmag
APRIL 8, 2022
They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone. Medicine & Health bone Disease Doublestranded gum induces loss RNA
Venture capital pours more money into RNA medicines with the launch of Replicate
Bio Pharma Dive
SEPTEMBER 8, 2021
The company, which focuses on self-replicating RNA, comes equipped with $40 million from Apple Tree Partners and a stamp of approval from the former research head at Biogen
Moderna founder's next big play in RNA raises $440 million
Bio Pharma Dive
AUGUST 30, 2021
Just a few months out of stealth mode, Laronde and its "endless RNA" technology have caught the attention of well-known investors like Fidelity, T. Rowe Price Associates and Invus
Roche adds to RNA drug deal streak with Ribometrix partnership
Bio Pharma Dive
JANUARY 6, 2021
The companies' pact is the latest addition to a growing list of deals involving startups developing chemical drugs to target RNA molecules
???????Research sheds light on mysterious messenger RNA modifications
Scienmag
MARCH 9, 2022
A team led by scientists at the University of Birmingham has come a step closer to uncovering the purpose of a distinctive set of modifications found at the beginning of messenger RNA which have long remained a fundamental mystery in molecular biology.
Single cell RNA sequencing uncovers new mechanisms of heart disease
Scienmag
MAY 10, 2022
Biology cell Disease heart mechanisms RNA sequencing single uncoversHypertrophic cardiomyopathy is a heart disease that leads to a stressed, swollen heart muscle. Due to a poor understanding of underlying mechanisms, effective clinical treatments are not available.
Next Generation RNA Therapeutics Summit
Pharma Phorum
APRIL 25, 2022
Are you looking to solve challenges with current RNA therapeutics, such as the degradation of RNA by RNAses, the difficulty of RNA crossing the cell membrane by diffusion and the immunogenicity elicited by exogenous RNA? Next generation RNA therapeutics can help!
Eli Lilly Pursues RNA Editing in New Partnership with ProQR
XTalks
SEPTEMBER 13, 2021
billion deal will see the companies use ProQR’s proprietary Axiomer RNA editing platform technology to advance editing oligonucleotide-based therapeutics toward clinical development and commercialization.
RNA Therapeutics 2022
Pharma Phorum
OCTOBER 18, 2021
SMi Group’s 13th Annual Conference: RNA Therapeutics 2022. Bolstering the latest advances and opportunities in RNA-based medicine. Delve into the latest innovations in novel RNA delivery and target specificity. Head of RNA Biology.
COVID-19 : Measuring viral RNA to predict which patients will die
Scienmag
NOVEMBER 26, 2021
Credit: CHUM The amount of a SARS-CoV-2 genetic material—viral RNA—in the blood is a reliable indicator in detecting which patients will die of the disease, a team led by Université de Montréal medical professor Dr.?Daniel Medicine & Health COVID19 die Measuring Patients predict RNA vira
Merck pays startup Orna $150M as ‘circular RNA’ attracts industry interest
Bio Pharma Dive
AUGUST 16, 2022
The pharmaceutical company has formed an alliance with Orna and invested $100 million in its Series B round, hoping the young biotech’s approach could lead to multiple new vaccines and drugs
HKUST researchers reveal RNA elements that enhance the cleavage of pre-miRNAs/shRNAs by DICER
Scienmag
APRIL 19, 2022
Biology cleavage DICER elements enhance HKUST premiRNAsshRNAs researchers reveal RNA
New analysis reveals ecological patterns and roles of marine RNA viruses
Scienmag
JUNE 9, 2022
Community- and “species”-level analysis on Global Ocean RNA sequences sampled from waters worldwide has shed light on the poorly understood diversity and ecological footprint of marine RNA viruses, according to a new report. The findings underscore the important roles marine RNA viruses play in the ocean ecosystem. Latest News analysis ecological Marine Patterns reveals RNA roles viruses
New open-source software automates RNA analysis to speed up research and drug development
Scienmag
MAY 3, 2022
LA JOLLA, CA—Scientists at Scripps Research have unveiled a new software tool for studying RNA (ribonucleic acid) molecules, which have a host of critical roles in organisms. Latest News analysis automates development Drug opensource research RNA software speed
Lilly joins RNA editing race with ProQR deal
Bio Pharma Dive
SEPTEMBER 9, 2021
An agreement with the Dutch biotech, which could be worth as much as $1.3 billion, expands Lilly's work in genetic medicine research
With Cryo-EM, Sloan Kettering Institute scientists determine structure of key factor in RNA quality control
Scienmag
JUNE 9, 2022
Biology control cryoEM determine factor Institute Kettering key quality RNA scientists Sloan structureNEW YORK, JUNE 9, 2022 – In biology, getting rid of stuff can be just as important as making it.
RNA-Dependent RNA Polymerase (RdRP or RNA Replicase) Inhibitor Drug Pipeline Market Research Report 2022 – ResearchAndMarkets.com
BioTech 365
FEBRUARY 3, 2022
RNA-Dependent RNA Polymerase (RdRP or RNA Replicase) Inhibitor Drug Pipeline Market Research Report 2022 – ResearchAndMarkets.com RNA-Dependent RNA Polymerase (RdRP or RNA Replicase) Inhibitor Drug Pipeline Market Research Report 2022 – ResearchAndMarkets.com DUBLIN–(BUSINESS WIRE)–The “RNA-Dependent RNA Polymerase (RdRP or RNA … Continue reading → Business Wire
RNA molecules control repair of human DNA in cancer cells
Scienmag
FEBRUARY 23, 2022
A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to better cancer treatments. It was long assumed that RNA molecules – basic molecules that exist […]. Latest News cancer cells control DNA human molecules repair RNA
How RNA-Based Pesticides Can Improve Pest Control
XTalks
NOVEMBER 9, 2021
Perhaps popularized by the COVID-19 vaccines, RNA-based technologies now have the potential to become the next best pesticide to combat crop pests, like insects and fungal pathogens. What are RNA-Based Pesticides? Advantages of RNA-Based Pesticides.
BioTuring enters collaboration to enable detailed single-cell RNA research
Pharma Phorum
JANUARY 19, 2022
The collaboration aims to “close the gap between single-cell RNA sequencing wet-lab services and single-cell data analysis solutions,” which will allow scientists to study the finest details that can be hard to access. News R&D pharma rna rna therapeutics Single Cell Analysis
Benchling launches purpose-built tools to accelerate RNA R&D
BioPharma Reporter
SEPTEMBER 7, 2022
Technology firm, Benchling, has developed what it calls the biopharma industryâs first set of full capabilities for designing, modelling, and studying both natural and chemically modified RNA in a single platform.
GSK dives into NASH, RNA interference with Arrowhead deal
Bio Pharma Dive
NOVEMBER 23, 2021
GSK has secured rights to a genetic medicine in early-stage human testing for NASH, a disease thought to affect millions of people and which has proven to be a tough target for drugmakers
Novel, sensitive, and robust single-cell RNA sequencing technique outperforms competition
Scienmag
JUNE 27, 2022
The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized the fields of medicine and biology by providing the ability to study the inner workings of thousands of cells at one go. Social & Behavioral Science competition outperforms RNA robust sensitive sequencing Singlecell technique
Lucerna is Illuminating the Mysteries of RNA to Solve Disease
BioSpace
SEPTEMBER 9, 2021
The company aims to make RNA molecules visible and druggable – opening the door to study RNA-based diseases
RNA Therapeutics Experience Renaissance Amidst Global Pandemic
BioSpace
AUGUST 4, 2021
RNA caught the public’s imagination in the form of mRNA vaccines against COVID-19, but RNA can be used in other ways, too, to make therapeutic proteins
Regulating the ribosomal RNA production line
Scienmag
JANUARY 22, 2021
coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].
Peanut studies reveal surprising truths about RNA and open the door to better understanding epigenetic mechanisms in plants
Scienmag
JANUARY 13, 2022
Medicine & Health door epigenetic mechanisms open Peanut plants reveal RNA Studies surprising truths UnderstandingPlants encounter microbes all the time, in the air, water, and soil. Some cause disease, others are neutral, but a few microbes promote plant health and growth.
Alnylam Files Lawsuits Against Pfizer and Moderna Over Patent Infringement of RNA Delivery Technology
XTalks
MARCH 21, 2022
Credited as a pioneering RNA interference (RNAi) therapeutics company, Alnylam Pharmaceuticals is taking Pfizer and Moderna to court, claiming that the companies’ use of the lipid nanoparticle (LNP)-based RNA delivery technology in their mRNA COVID-19 vaccines infringes on a patented technology.
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