Moderna says its coronavirus vaccine sparks immune response in older people

Bio Pharma Dive

An initial look at the vaccine's effects on the elderly shows those in their 70s had similar responses to those under 55, Moderna told a government panel

The host immune response in COVID-19 and beyond

Pharma Phorum

MeMed CEO Dr. Eran Eden explores the relationship between the host immune response and SARS-CoV-2 infection and how technology could help personalise treatment strategies. One of these involves listening to what the body’s own immune system can tell us.

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Strong immune response underlies acute kidney injury related to COVID-19

Scienmag

— Mayo Clinic researchers have found that acute kidney injury associated with COVID-19 resembles sepsis-caused kidney injury, and the immune response triggered by the infection plays a pivotal role. ROCHESTER, Minn. The findings, published in Mayo Clinic Proceedings, also suggest that mitochondrial dysfunction — a loss of function in cellular energy production — is commonly […]. Infectious Emerging Diseases Infectious/Emerging Diseases Medicine/Health

Scientists blueprint bacterial enzyme believed to “stealthily” suppress immune response

Scienmag

Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a “stealthy” role in the progression of infection by reducing the immune response. Blueprints such as these allow drug designers to uncover potential weaknesses in bacterial arsenals as they seek to develop new therapeutics that […].

Potential cancer therapy may boost immune response

Scienmag

The addition of an anti-inflammatory medication to a common chemotherapy drug may improve immune response in patients by activating cells to fight cancer Credit: Cedars-Sinai LOS ANGELES (EMBARGOED UNTIL DEC.

Off-target immune response could predict COVID-19 severity

Scienmag

The presence of special immune system defense molecules, called autoimmune antibodies, has been strongly tied to how poorly people fare when hospitalized with COVID-19, a new study shows. Medicine & Health COVID19 immune Offtarget predict response severity

How a receptor shapes the immune response

Scienmag

Immune cells specialize to ensure the most efficient defense against viruses and other pathogens. Researchers at the University of Basel have shed light on this specialization of T cells and shown that it occurs differently in the context of an acute and a chronic infection. This could be relevant for new approaches against chronic viral […]. Biology Immunology/Allergies/Asthma Medicine/Health Molecular Biology Virology

Study: Antibody Reduces Death in COVID-19 Patients Unable to Mount an Immune Response

BioSpace

?The new data shows REGEN-COV reduced the risk of death in hospitalized patients unable to mount their own immune response by 20

Study identifies noncoding RNA involved in immune response and sepsis

Scienmag

AstraZeneca's COVID-19 Vaccine Boosts Immune Response in Older, Younger Adults

BioSpace

FDA greenlit the restart of AstraZeneca’s Phase III COVID-19 vaccine trial, the company said the preventative medication boosts immune responses in older and younger adults against the novel coronavirus Days after the U.S.

SARS-CoV-2 curtails immune response in the gut

Scienmag

Study finds that children’s immune response protects against COVID-19

Scienmag

September 21, 2020–(BRONX, NY)–The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

Infant antibiotic exposure can affect future immune responses toward allergies

Scienmag

Early life exposure to antibotics in utero and through mother’s milk disrupts beneficial gut bacteria, compromising T-cell development, Rutgers research shows Exposure to antibiotics in utero and infancy can lead to an irreversible loss of regulatory T-cells in the colon-a valuable component of the immune system’s response toward allergens in later life – after only […].

Triggering tumor antiviral immune response in triple negative breast cancer

Scienmag

14, 2021) – Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body’s immune response. HOUSTON – (Jan.

Sanofi-GSK COVID-19 Vaccine Hits Snag With Insufficient Immune Response in 50+ Population

BioSpace

The COVID-19 vaccine candidate developed by Sanofi and GlaxoSmithKline hit a snag that will delay the launch of a Phase III study due to an insufficient immune response in older trial patients

Gut’s immune response in COVID-19 may not provide efficient protection of other organs

Scienmag

A study of immune cells circulating in the blood hints the gut’s immune response to COVID-19 infection may not provide sufficient whole-body immunity from the virus Our guts may not provide long-lasting systemic immunity from COVID-19, which is where immune cells circulate through the body to provide protection to other organs, finds a new study […].

Study: CureVac’s COVID-19 Vaccine Produces Immune Responses in Healthy Volunteers

BioSpace

Newly announced results of a Phase I dose-escalation study show CureVac’s COVID-19 vaccine candidate, CVnCoV, generates noticeable immune responses in healthy volunteers

‘Goldilocks’ neonatal immune response may protect against autism

Scienmag

Mid-range level of immune protein associated with lowest risk Philadelphia, November 10, 2020 – The causes of autism spectrum disorder (ASD) – including genetic and environmental factors – are not entirely understood. Many studies have already shown that serious maternal infection during pregnancy is associated with increased risk for offspring in both people and animals. […].

Eurofins Launches Quantitative Antibody Test to Measure Immune Response to COVID-19 and Vaccines

BioTech 365

Exercise benefit in breast cancer linked to improved immune responses

Scienmag

BOSTON – Exercise training may slow tumor growth and improve outcomes for females with breast cancer – especially those treated with immunotherapy drugs – by stimulating naturally occurring immune mechanisms, researchers at Massachusetts General Hospital (MGH) and Harvard […]. Tumors grew more slowly and responded better to immunotherapy in mice that exercised compared with sedentary mice.

#news #biotech Harnessing the immune response against common moles to combat melanoma

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Harnessing the immune response against common moles to combat melanoma.Harnessing the immune response against common moles to combat melanoma aliu Wed, 06/23/2021 – 12:57 from FierceBiotech: Biotech … Continue reading → #news

Intranasal influenza vaccine Phase 1 study shows strong immune response

BioPharma Reporter

A single-dose intranasal influenza vaccine is safe and produces a durable immune response, according to a Phase 1 study published in the Journal of Clinical Investigation this week.

Early data shows CanSinoBIO’s inhaled COVID-19 vaccine triggers immune response

Pharma Times

No serious side effects were observed in the Phase I trial

Canadian study investigates immune response and vaccine hesitancy among Canada’s South Asian communities

BioTech 365

Canadian study investigates immune response and vaccine hesitancy among Canada’s South Asian communities Canadian study investigates immune response and vaccine hesitancy among Canada’s South Asian communities HAMILTON, Ontario, June 03, 2021 (GLOBE NEWSWIRE) — The Government of Canada, through its … Continue reading → GlobeNewswire

Eli Lilly and Kumquat Seek Enhanced Tumor-Specific Immune Response in $2B+ Deal

BioSpace

?The two companies announced their exclusive collaboration that will harness Kumquat’s small molecule immuno-oncology platform's capabilities to discover novel clinical candidates

Rhesus macaques develop promising immune response to SARS-CoV-2

Scienmag

Results suggest lasting immunity after infection In a promising result for the success of vaccines against COVID-19, rhesus macaque monkeys infected with the human coronavirus SARS-CoV-2 developed protective immune responses that might be reproduced with a vaccine.

AstraZeneca’s COVID-19 Vaccine Delivers Strong Immune Response, Study Confirms

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study.

Strong immune responses seen in adults of all ages

The Pharma Data

response in the over-50s, the age group deemed at higher risk for contracting the severe form of the virus. . The interim results from the phase 2 trial on the vaccine, published today, on the contrary, showed a “ strong neutralizing antibody response” ?

#news #biotech COVID-flu combo vaccine from Novavax sparks immune response to both viruses in animals

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: COVID-flu combo vaccine from Novavax sparks immune response to both viruses in animals.COVID-flu combo vaccine from Novavax sparks immune response to both viruses in animals arlene.weintraub Mon, … Continue reading → #news

Scientists reveal structural details of how SARS-CoV-2 variants escape immune response

Scienmag

The findings provide direction for future vaccines or therapies that may offer broader protection against variants LA JOLLA, CA–Fast-spreading variants of the COVID-19-causing coronavirus, SARS-CoV-2, carry mutations that enable the virus to escape some of the immune response created naturally or by vaccination.

Modeling future COVID-19 cases under a variety of immune responses, and with or without vaccines

Scienmag

Their work emphasizes how dependent the future course of the pandemic is on the nature of the adaptive immune response to this virus and on […]. Researchers who adapted standard epidemiological models to explore how the COVID-19 pandemic trajectory might unfold in the next five years report diverse scenarios ranging from recurring severe epidemics to elimination.

Second-Generation mRNA COVID-19 Vaccine Candidate, CV2CoV, Demonstrates Improved Immune Response and Protection in Preclinical Study

The Pharma Data

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV.

Many COVID-19 patients produce immune responses against their body’s tissues or organs

Scienmag

A University of Birmingham-led study funded by the UK Coronavirus Immunology Consortium has found that many patients with COVID-19 produce immune responses against their body’s own tissues or organs. COVID-19 has been associated with a variety of unexpected symptoms, both at the time of infection and for many months afterwards. It is not fully understand […]. Infectious Emerging Diseases Immunology/Allergies/Asthma Infectious/Emerging Diseases Medicine/Health

Ultrasensitive blood test detects viral protein, confirms vaccine activates robust immune response

Scienmag

In series of samples collected from individuals vaccinated against COVID-19, an ultrasensitive test detected low concentrations of circulating antigen; Following robust production of antibodies, viral protein declined to undetectable levels The carefully orchestrated dance between the immune system and the viral proteins that induce immunity against COVID-19 may be more complex than previously thought.

GSK and Sanofi report positive data from COVID-19 vaccine candidate trial: Strong immune responses seen in adults of all ages

BioPharma Reporter

Sanofi and GSK announced today that their COVID-19 vaccine candidate demonstrated strong immune responses across all adult age groups in a Phase 2 trial.

Theratechnologies Announces New Data Demonstrating Tesamorelin’s Positive Effect on Immune Response Linked to Liver Inflammation

BioTech 365

Theratechnologies Announces New Data Demonstrating Tesamorelin’s Positive Effect on Immune Response Linked to Liver Inflammation Theratechnologies Announces New Data Demonstrating Tesamorelin’s Positive Effect on Immune Response Linked to Liver Inflammation Data presented at ENDO 2021 MONTREAL, March 20, 2021 (GLOBE … Continue reading → GlobeNewswire

Johns Hopkins Scientists Discover Possible Key to Controlling COVID-19 Immune Response

BioSpace

They believe that by inhibiting factor D, it would reduce the inflammatory reactions that make COVID-19 so deadly