NIH study finds mixing COVID-19 boosters increases immune response

Bio Pharma Dive

Results suggested Pfizer's and Moderna's vaccines may serve as a more potent booster for those who initially received Johnson & Johnson's shot, although data are limited and preliminary

Moderna vaccine safe and spurs immune response in kids, company says

Bio Pharma Dive

The trial results should allow the company to ask the FDA for approval of its vaccine in younger children, just as Pfizer nears a crucial decision for its shot in 5- to 11-year olds

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Pfizer says coronavirus vaccine is safe and spurs immune response in children

Bio Pharma Dive

The results position Pfizer and BioNTech to seek clearance in children as young as five years old. But the companies haven't yet shared data on a rare heart inflammation associated with their shot that's a concern for regulators

Moderna says its coronavirus vaccine sparks immune response in older people

Bio Pharma Dive

An initial look at the vaccine's effects on the elderly shows those in their 70s had similar responses to those under 55, Moderna told a government panel

Nature article: SARS-CoV-2 disrupts timing of immune response

Scienmag

to downgrade its immune response. In severe COVID-19, however, this messenger is released at the very beginning of the infection, thus blocking the early control of the pathogen by the innate immune system.

Genetic ancestry shapes immune response to influenza virus

Scienmag

A new study aimed at explaining differential susceptibility to viral epidemics reveals that ancestry and associated genetic variation can explain population-level differences in the immune response to the flu virus and perhaps also to COVID-19. Latest News ancestry genetic immune influenza response shapes virus

The host immune response in COVID-19 and beyond

Pharma Phorum

MeMed CEO Dr. Eran Eden explores the relationship between the host immune response and SARS-CoV-2 infection and how technology could help personalise treatment strategies. One of these involves listening to what the body’s own immune system can tell us.

Study identifies noncoding RNA involved in immune response and sepsis

Scienmag

Strong immune response underlies acute kidney injury related to COVID-19

Scienmag

— Mayo Clinic researchers have found that acute kidney injury associated with COVID-19 resembles sepsis-caused kidney injury, and the immune response triggered by the infection plays a pivotal role. ROCHESTER, Minn. The findings, published in Mayo Clinic Proceedings, also suggest that mitochondrial dysfunction — a loss of function in cellular energy production — is commonly […]. Infectious Emerging Diseases Infectious/Emerging Diseases Medicine/Health

Scientists blueprint bacterial enzyme believed to “stealthily” suppress immune response

Scienmag

Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a “stealthy” role in the progression of infection by reducing the immune response. Blueprints such as these allow drug designers to uncover potential weaknesses in bacterial arsenals as they seek to develop new therapeutics that […].

MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio

BioTech 365

MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed BV® test recently … Continue reading → GlobeNewswire

MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio

BioTech 365

MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed BV® test recently … Continue reading → GlobeNewswire

MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio

BioTech 365

MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed raises $93M to accelerate commercialization of its host immune-response product portfolio MeMed BV® test recently … Continue reading → GlobeNewswire

How a receptor shapes the immune response

Scienmag

Immune cells specialize to ensure the most efficient defense against viruses and other pathogens. Researchers at the University of Basel have shed light on this specialization of T cells and shown that it occurs differently in the context of an acute and a chronic infection. This could be relevant for new approaches against chronic viral […]. Biology Immunology/Allergies/Asthma Medicine/Health Molecular Biology Virology

New understanding of the deleterious immune response in rheumatoid arthritis

Scienmag

Credit: (C) Erica Tandori Researchers within the Biomedicine Discovery Institute at Monash University have made a breakthrough in understanding the role played by high-risk immune genes associated with the development of rheumatoid arthritis (RA).

SARS-CoV-2 curtails immune response in the gut

Scienmag

COVAXIN™ (BBV152) Booster Dose Study Demonstrates Robust Immune Responses and Long-Term Safety

BioTech 365

COVAXIN™ (BBV152) Booster Dose Study Demonstrates Robust Immune Responses and Long-Term Safety COVAXIN™ (BBV152) Booster Dose Study Demonstrates Robust Immune Responses and Long-Term Safety Participants receiving a booster dose six months after second dose of COVAXIN™ saw significant increase (>10-fold … Continue reading → GlobeNewswire

3D-Printed Vaccine Patch Offers Enhanced Immune Response, Comfort Level

BioSpace

The patch is not only painless, it requires less vaccine to generate the same or greater effects

AstraZeneca’s COVID-19 Vaccine Delivers Strong Immune Response, Study Confirms

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study.

Mix-and-Match Vaccine Platform May Boost Immune Response & Duration

BioSpace

IDRI is working with a newly-formed consortium to develop a next-gen COVID-19 vaccine that will be stable at routine temperatures and that may be able to confer immunity for a longer duration

Study: Antibody Reduces Death in COVID-19 Patients Unable to Mount an Immune Response

BioSpace

?The new data shows REGEN-COV reduced the risk of death in hospitalized patients unable to mount their own immune response by 20

AstraZeneca's COVID-19 Vaccine Boosts Immune Response in Older, Younger Adults

BioSpace

FDA greenlit the restart of AstraZeneca’s Phase III COVID-19 vaccine trial, the company said the preventative medication boosts immune responses in older and younger adults against the novel coronavirus Days after the U.S.

Study finds that children’s immune response protects against COVID-19

Scienmag

September 21, 2020–(BRONX, NY)–The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

Immune response to COVID-19 vaccine different with prior infection

Scienmag

A quick stick in the arm with an approved COVID-19 vaccine elicits a flurry of activity in the body’s immune system. Biology COVID19 immune infection prior response vaccine

Strong immune responses seen in adults of all ages

The Pharma Data

response in the over-50s, the age group deemed at higher risk for contracting the severe form of the virus. . The interim results from the phase 2 trial on the vaccine, published today, on the contrary, showed a “ strong neutralizing antibody response” ?

Insights into how diet-related factors may influence immune response for cancer patients

Scienmag

Dietary fiber and probiotics impact gut bacteria and immunotherapy responses in melanoma patients, a new study in patients shows. A high-fiber diet was associated with improved survival and response to immunotherapy, the results reveal. The influence of the gut microbiome on therapeutic response has now been demonstrated in numerous human cohorts and in preclinical models. […]. Latest News cancer dietrelated factors immune influence insights Patients response

Off-target immune response could predict COVID-19 severity

Scienmag

The presence of special immune system defense molecules, called autoimmune antibodies, has been strongly tied to how poorly people fare when hospitalized with COVID-19, a new study shows. Medicine & Health COVID19 immune Offtarget predict response severity

Infant antibiotic exposure can affect future immune responses toward allergies

Scienmag

Early life exposure to antibotics in utero and through mother’s milk disrupts beneficial gut bacteria, compromising T-cell development, Rutgers research shows Exposure to antibiotics in utero and infancy can lead to an irreversible loss of regulatory T-cells in the colon-a valuable component of the immune system’s response toward allergens in later life – after only […].

Delaying second dose of mRNA COVID-19 vaccine produces stronger immune response

The Pharma Data

The first peer-reviewed study in North America examining the timing between the first and second doses of COVID-19 mRNA vaccines shows that a longer dose interval leads to a stronger immune response. Informing immunization strategy decisions.

AstraZeneca’s Vaccine Produced Immune Responses in Older Patients

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, elicited immune responses in older coronavirus patients similar to ones generated in younger adults, lending more promise to a vaccine that’s seen as one of the leading contenders in the race to become the first approved COVID-19 vaccine.

Triggering tumor antiviral immune response in triple negative breast cancer

Scienmag

14, 2021) – Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body’s immune response. HOUSTON – (Jan.

Drug made from pig intestine helps escape the “trap” of clot-causing immune response

Scienmag

When the body attempts to fight off an infection, immune cells called neutrophils may shoot out spider web-like networks of toxic proteins to help contain the invaders. Latest News clotcausing Drug escape helps immune intestine pig response trapHowever, when not properly regulated, these web-like neutrophil extracellular traps, or NETs, play a role in forming blood clots and promoting inflammation for several diseases, including COVID-19. Utilizing […].

Using mice models to gain insight into immune response to SARS-CoV-2

BioPharma Reporter

Charles River and La Jolla Institute for Immunology (LJI) are collaborating on a new project to uncover how different cells in the human immune system respond to SARS-CoV-2 in early, acute infection.

Chimeric exosomes co-activate immune response and tumor microenvironment for cancer immunotherapy

Scienmag

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed macrophage–tumor chimeric exosomes that co-activate the immune response and tumor microenvironment to support cancer immunotherapy.

Gut’s immune response in COVID-19 may not provide efficient protection of other organs

Scienmag

A study of immune cells circulating in the blood hints the gut’s immune response to COVID-19 infection may not provide sufficient whole-body immunity from the virus Our guts may not provide long-lasting systemic immunity from COVID-19, which is where immune cells circulate through the body to provide protection to other organs, finds a new study […].

Sanofi-GSK COVID-19 Vaccine Hits Snag With Insufficient Immune Response in 50+ Population

BioSpace

The COVID-19 vaccine candidate developed by Sanofi and GlaxoSmithKline hit a snag that will delay the launch of a Phase III study due to an insufficient immune response in older trial patients

‘Goldilocks’ neonatal immune response may protect against autism

Scienmag

Mid-range level of immune protein associated with lowest risk Philadelphia, November 10, 2020 – The causes of autism spectrum disorder (ASD) – including genetic and environmental factors – are not entirely understood. Many studies have already shown that serious maternal infection during pregnancy is associated with increased risk for offspring in both people and animals. […].

Eurofins Launches Quantitative Antibody Test to Measure Immune Response to COVID-19 and Vaccines

BioTech 365

Second-Generation mRNA COVID-19 Vaccine Candidate, CV2CoV, Demonstrates Improved Immune Response and Protection in Preclinical Study

The Pharma Data

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV.

Exercise benefit in breast cancer linked to improved immune responses

Scienmag

BOSTON – Exercise training may slow tumor growth and improve outcomes for females with breast cancer – especially those treated with immunotherapy drugs – by stimulating naturally occurring immune mechanisms, researchers at Massachusetts General Hospital (MGH) and Harvard […]. Tumors grew more slowly and responded better to immunotherapy in mice that exercised compared with sedentary mice.

UK study shows mixing Pfizer and AstraZeneca COVID-19 vaccines with Moderna elicits better immune response

Pharma Times

Results show support in favour of heterologous dosing which may help to advance vaccination programmes in poorer countries

Intranasal influenza vaccine Phase 1 study shows strong immune response

BioPharma Reporter

A single-dose intranasal influenza vaccine is safe and produces a durable immune response, according to a Phase 1 study published in the Journal of Clinical Investigation this week.

Study: CureVac’s COVID-19 Vaccine Produces Immune Responses in Healthy Volunteers

BioSpace

Newly announced results of a Phase I dose-escalation study show CureVac’s COVID-19 vaccine candidate, CVnCoV, generates noticeable immune responses in healthy volunteers