Moderna says its coronavirus vaccine sparks immune response in older people

Bio Pharma Dive

An initial look at the vaccine's effects on the elderly shows those in their 70s had similar responses to those under 55, Moderna told a government panel

AstraZeneca's COVID-19 Vaccine Boosts Immune Response in Older, Younger Adults

BioSpace

FDA greenlit the restart of AstraZeneca’s Phase III COVID-19 vaccine trial, the company said the preventative medication boosts immune responses in older and younger adults against the novel coronavirus Days after the U.S.

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AstraZeneca’s COVID-19 Vaccine Delivers Strong Immune Response, Study Confirms

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study.

AstraZeneca’s Vaccine Produced Immune Responses in Older Patients

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, elicited immune responses in older coronavirus patients similar to ones generated in younger adults, lending more promise to a vaccine that’s seen as one of the leading contenders in the race to become the first approved COVID-19 vaccine.

Johns Hopkins Scientists Discover Possible Key to Controlling COVID-19 Immune Response

BioSpace

They believe that by inhibiting factor D, it would reduce the inflammatory reactions that make COVID-19 so deadly

Study finds that children’s immune response protects against COVID-19

Scienmag

September 21, 2020–(BRONX, NY)–The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

#news #biotech Moderna’s COVID-19 vaccine spurs immune response in older adults

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Moderna’s COVID-19 vaccine spurs immune response in older adults.Moderna’s COVID-19 vaccine spurs immune response in older adults ntaylor Wed, 09/30/2020 – 06:26 from FierceBiotech: Biotech [link].

Cells sacrifice themselves to boost immune response to viruses

Scienmag

Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection. New research appearing in the journal Nature Immunology describes how different cells in the immune system work together, communicate, and – in the case of cells called neutrophils – bring about their own […].

Modeling future COVID-19 cases under a variety of immune responses, and with or without vaccines

Scienmag

Their work emphasizes how dependent the future course of the pandemic is on the nature of the adaptive immune response to this virus and on […]. Researchers who adapted standard epidemiological models to explore how the COVID-19 pandemic trajectory might unfold in the next five years report diverse scenarios ranging from recurring severe epidemics to elimination.

#news #biotech Pfizer, BioNTech report ‘strong’ immune response in animals to COVID-19 mRNA vaccine candidate

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Pfizer, BioNTech report ‘strong’ immune response in animals to COVID-19 mRNA vaccine candidate.Pfizer, BioNTech report ‘strong’ immune response in animals to COVID-19 mRNA vaccine candidate arlene.weintraub Wed, … Continue reading → #news

Pfizer-BioNTech reports strong immune response in animals to its COVID-19 vaccine

The Pharma Data

Pfizer-BioNTech announced Wednesday that preliminary preclinical data from mouse and macaque monkey models showed a strong immune response from its mRNA COVID-19 vaccine. . Photo by Md. Tareq Aziz Touhid.

Early data shows Russia’s Sputnik V COVID-19 vaccine produces immune response

Pharma Phorum

A trial of Russia’s Sputnik V coronavirus vaccine has shown the jab produces an immune response, although the study was too small to produce conclusive findings, particularly on safety. The vaccine also produced a T-cell response within 28 days, a secondary outcome.

Delayed immune responses may drive COVID-19 mortality rates among men and the elderly

Scienmag

Immune responses to SARS-CoV-2 may depend on viral load and infection time course COVID-19 (SARS-CoV-2) infections tend to be more severe among older adults and males, yet the mechanisms underlying increased mortality in these two demographics are unknown.

#news #biotech Editing immune response could make gene therapy more effective

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Editing immune response could make gene therapy more effective.Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell.

Novavax’s COVID-19 vaccine produces immune response in early study

Pharma Times

Vaccine was generally well-tolerated with only a few mild side-effects reported

Early NK cell-mediated immune response may contribute to severe COVID-19

Scienmag

Credit: Markus Marcetic Researchers may have come one step closer toward understanding how the immune system contributes to severe COVID-19.

J&J’s Single-Dose COVID-19 Vaccine Generates Strong Immune Response, Early Data Shows

BioSpace

The company posted an interim analysis of its Phase I/IIa trial that showed a single dose of JNJ-78436735 induced a strong neutralizing antibody response in nearly all participants and was well-tolerated

IL-21 protein a key part of immune response to central nervous system infections

Scienmag

— Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system. HERSHEY, Pa. The results of their recent study support further investigation into using IL-21 as a therapeutic agent for persistent central nervous system infections. CD4 T […]. Infectious Emerging Diseases Immunology/Allergies/Asthma Infectious/Emerging Diseases Medicine/Health

Diomics Announces Agreement With Department of Defense to Accelerate Development and Testing of Diocheck™ SARS-CoV-2 Immune Response Indicator Patch

BioTech 365

Simple Skin Patch Empowers Individuals to Monitor for Immune Response to Help Stop COVID-19 Spread SAN DIEGO–(BUSINESS WIRE)–Diomics, a San Diego-based biotech company, today announced that it has been awarded a $2,125,000 Medical Technology Enterprise Consortium (MTEC) Other Transaction Agreement … Continue reading → Business Wire

Sanford Burnham Prebys receives $3M NIH award for drugs that restore immune response to COVID-19

Scienmag

Scientists will study how SARS-CoV-19 hijacks the immune system and creates a ‘cytokine storm’ Credit: Sanford Burnham Prebys Medical Discovery Institute. Scientists at Sanford Burnham Prebys Medical Discovery Institute have received a $3 million grant from the National Institutes of Health (NIH) to study how SARS-CoV-19 weakens the immune system–and identify drugs to help infected […].

Finding clues to a successful immune response in the T cells of COVID-19 patients

Scienmag

While antibodies may fade fast, T cells appear to be long-lived and might confer lasting immunity. When news about a novel coronavirus switched from a chronicle of its progress in China to headlines about a worldwide COVID-19 pandemic, Gladstone Institutes scientist Nadia Roan, PhD, was in the midst of publishing several papers on T cells […]. Medicine & Health AIDS/HIV Biology Cell Biology Immunology/Allergies/Asthma Infectious/Emerging Diseases Virology

The Lancet Infectious Diseases: Preliminary results find vaccine candidate based on inactivated SARS-CoV-2 virus is safe and induces an immune response in healthy volunteers

Scienmag

Phase 1/2 randomised controlled trial of an inactivated SARS-CoV-2 vaccine candidate was carried out in China between 29 April and 30 July 2020 and involved more than 600 healthy volunteers. Peer reviewed / Randomised clinical trial / People The Lancet Infectious Diseases: Preliminary results find vaccine candidate based on inactivated SARS-CoV-2 virus is safe and […].

Median Technologies: Promising Results on the Use of the IBiopsy® Platform in the Context of Measuring the Anti-tumor Immune Response

BioTech 365

Solid gets all-clear from FDA to restart gene therapy trial

Bio Pharma Dive

Worrisome immune responses had led the FDA to halt Solid's study. Now, the agency will permit Solid to continue after the biotech made adjustments to its manufacturing and patient enrollment procedures

NIHR, UKRI stream £8.4m into coronavirus studies

Pharma Times

The studies aim to increase understanding on immune responses to SARS-CoV-2

Icelandic COVID-19 Study: Long-Lasting Antibodies and 0.3% Death Rate

BioSpace

There is new research out of Iceland that suggests the body’s immune response to COVID-19 lasts longer than other research has suggested

Sinopharm Publishes Positive Data from Phase I/II COVID-19 Vaccine Study

BioSpace

A COVID-19 vaccine candidate developed by Chinese pharmaceutical company Sinopharm triggered antibody-based immune responses in early and mid-stage trials

CureVac Touts Positive Preclinical Data for COVID-19 Vaccine | 2020-10-26

The Pharma Data

German drugmaker CureVac said preclinical studies of its COVID-19 vaccine candidate, CVnCoV, showed the vaccination prompted a successful immune response.

Clover Biopharmaceuticals Announces Positive Preclinical Data and Updates on Phase 1 Study for its Adjuvanted S-Trimer COVID-19 Vaccine Candidate

BioTech 365

Preclinical data show Clover’s protein-based adjuvanted COVID-19 vaccine candidate, S-Trimer, induces a strong neutralizing immune response in animalsand protects nonhuman primates from SARS-CoV-2 challenge Strong immune response and protection observed with adjuvant systems from GSK and Dynavax led to inclusion … Continue reading → Business Wire

New immunotherapy to beat cancer

Scienmag

Cancer immunotherapy is the manipulation of the immune responses naturally present in the human body to fight cancer. Often, these immune responses are blocked by cells or molecules that prevent them from killing cancer cells, and the tumour is able to establish itself and grow. In 2004, Sophie Lucas, researcher at the University of Louvain […]. Cancer cancer Cell Biology Immunology/Allergies/Asthma Medicine/Health Microbiology

Vycellix CEO to Present its Universal Cell Program (VY-UC) for Off-the-Shelf NK Cell Therapy at Allogeneic Cell Therapies Summit

BioTech 365

-Proof-of-concept achieved for VY-UC to engineer donor cells without the complexities of gene-editing -Novel platform abrogates cellular immune response and obviates the need for immunosuppressive drugs TAMPA, Fla. &

Equipping the Immune System to Fight Against COVID-19

BioSpace

When someone gets sick with COVID-19, there is a lag in an efficient immune response, giving the virus time to do significant damage before the immune system can reign in the infection

Ludwig study finds a common nutritional supplement might boost cancer immunotherapy

Scienmag

Credit: Ludwig Cancer Research OCTOBER 5, 2020, NEW YORK – A Ludwig Cancer Research study has uncovered a mechanism by which the tumor’s harsh internal environment sabotages T lymphocytes, leading cellular agents of the anticancer immune response.

Elkhorn coral actively fighting off diseases on reef, study finds

Scienmag

Findings showed coral has core immune response regardless of disease type Credit: Photo: Margaret Miller, SECORE International MIAMI–As the world enters a next wave of the ongoing COVID-19 pandemic, we are aware now more than ever of the importance of a healthy immune system to protect ourselves from disease.

Study connects hormones we’re born with to lifetime risk for immunological diseases

Scienmag

Credit: Michigan State University Differences in biological sex can dictate lifelong disease patterns, says a new study by Michigan State University researchers that links connections between specific hormones present before and after birth with immune response and lifelong immunological disease development.

Protein that keeps immune system from freaking out could form basis for new therapeutics

Scienmag

Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction, supports a mechanism critical for survival in mouse models of sepsis and colitis Credit: UC San Diego Health Sciences The immune response to infections is a delicate balance.

NYUAD researchers discover immune evasion strategy used by Malaria-causing parasite

Scienmag

Genocea Announces Upcoming Data Presentations at Virtual SITC 2020

BioTech 365

Will showcase clinical and immune responses from the ongoing GEN-009 Phase 1/2a trial Will provide a detailed introduction to GEN-011, an adoptive T cell therapy designed to improve upon the limitations of TIL and TCR therapies Will share new insights … Continue reading → GlobeNewswire

Vaccine ingredients could be hiding in small molecule libraries

Scienmag

Long-term COVID-19 containment will be shaped by strength, duration of immunity

Scienmag

Credit: Tumisu from Pixabay New research suggests that the impact of natural and vaccine-induced immunity will be key factors in shaping the future trajectory of the global coronavirus pandemic, known as COVID-19.