Moderna says its coronavirus vaccine sparks immune response in older people

Bio Pharma Dive

An initial look at the vaccine's effects on the elderly shows those in their 70s had similar responses to those under 55, Moderna told a government panel

Potential cancer therapy may boost immune response

Scienmag

The addition of an anti-inflammatory medication to a common chemotherapy drug may improve immune response in patients by activating cells to fight cancer Credit: Cedars-Sinai LOS ANGELES (EMBARGOED UNTIL DEC.

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Study identifies noncoding RNA involved in immune response and sepsis

Scienmag

Triggering tumor antiviral immune response in triple negative breast cancer

Scienmag

14, 2021) – Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body’s immune response. HOUSTON – (Jan.

AstraZeneca's COVID-19 Vaccine Boosts Immune Response in Older, Younger Adults

BioSpace

FDA greenlit the restart of AstraZeneca’s Phase III COVID-19 vaccine trial, the company said the preventative medication boosts immune responses in older and younger adults against the novel coronavirus Days after the U.S.

AstraZeneca’s COVID-19 Vaccine Delivers Strong Immune Response, Study Confirms

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study.

Eurofins Launches Quantitative Antibody Test to Measure Immune Response to COVID-19 and Vaccines

BioTech 365

Intranasal influenza vaccine Phase 1 study shows strong immune response

BioPharma Reporter

A single-dose intranasal influenza vaccine is safe and produces a durable immune response, according to a Phase 1 study published in the Journal of Clinical Investigation this week.

AstraZeneca’s Vaccine Produced Immune Responses in Older Patients

The Pharma Data

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, elicited immune responses in older coronavirus patients similar to ones generated in younger adults, lending more promise to a vaccine that’s seen as one of the leading contenders in the race to become the first approved COVID-19 vaccine.

Rhesus macaques develop promising immune response to SARS-CoV-2

Scienmag

Results suggest lasting immunity after infection In a promising result for the success of vaccines against COVID-19, rhesus macaque monkeys infected with the human coronavirus SARS-CoV-2 developed protective immune responses that might be reproduced with a vaccine.

Study: CureVac’s COVID-19 Vaccine Produces Immune Responses in Healthy Volunteers

BioSpace

Newly announced results of a Phase I dose-escalation study show CureVac’s COVID-19 vaccine candidate, CVnCoV, generates noticeable immune responses in healthy volunteers

Study finds that children’s immune response protects against COVID-19

Scienmag

September 21, 2020–(BRONX, NY)–The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

Medicago Says COVID-19 Vaccine Candidate Triggers Promising Immune Response | 2020-11-10

The Pharma Data

Canadian biopharmaceutical company Medicago has announced that its investigational COVID-19 vaccine generated “significant antibody and cellular immune responses” after two doses in all subjects in an early-stage clinical trial. He said the company will potentially supply 76 million doses of the plant-based vaccine, which uses noninfectious virus-like particles to mimic the coronavirus in order to induce an immune response.

Johns Hopkins Scientists Discover Possible Key to Controlling COVID-19 Immune Response

BioSpace

They believe that by inhibiting factor D, it would reduce the inflammatory reactions that make COVID-19 so deadly

‘Goldilocks’ neonatal immune response may protect against autism

Scienmag

Mid-range level of immune protein associated with lowest risk Philadelphia, November 10, 2020 – The causes of autism spectrum disorder (ASD) – including genetic and environmental factors – are not entirely understood. Many studies have already shown that serious maternal infection during pregnancy is associated with increased risk for offspring in both people and animals. […].

#news #biotech China’s Sinovac sees speedy immune response with COVID-19 shot in early trials

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: China’s Sinovac sees speedy immune response with COVID-19 shot in early trials.China’s Sinovac sees speedy immune response with COVID-19 shot in early trials badams Wed, 11/18/2020 – … Continue reading → #news

#news #biotech CureVac links COVID-19 vaccine to immune response, setting it up to enter pivotal trial

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: CureVac links COVID-19 vaccine to immune response, setting it up to enter pivotal trial.CureVac links COVID-19 vaccine to immune response, setting it up to enter pivotal trial … Continue reading → #news

#news #biotech GSK sees ‘robust immune response’ from RSV vaccine hopefuls

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GSK sees ‘robust immune response’ from RSV vaccine hopefuls.GSK sees ‘robust immune response’ from RSV vaccine hopefuls badams Wed, 10/21/2020 – 04:07 from FierceBiotech: Biotech [link].

Cells sacrifice themselves to boost immune response to viruses

Scienmag

Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection. New research appearing in the journal Nature Immunology describes how different cells in the immune system work together, communicate, and – in the case of cells called neutrophils – bring about their own […].

#news #biotech Moderna’s COVID-19 vaccine spurs immune response in older adults

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Moderna’s COVID-19 vaccine spurs immune response in older adults.Moderna’s COVID-19 vaccine spurs immune response in older adults ntaylor Wed, 09/30/2020 – 06:26 from FierceBiotech: Biotech [link].

Modeling future COVID-19 cases under a variety of immune responses, and with or without vaccines

Scienmag

Their work emphasizes how dependent the future course of the pandemic is on the nature of the adaptive immune response to this virus and on […]. Researchers who adapted standard epidemiological models to explore how the COVID-19 pandemic trajectory might unfold in the next five years report diverse scenarios ranging from recurring severe epidemics to elimination.

AZ’s COVID-19 vaccine produces ‘encouraging’ immune response in older adults

Pharma Times

New findings from phase 2 study published in The Lancet

#news #biotech Pfizer, BioNTech report ‘strong’ immune response in animals to COVID-19 mRNA vaccine candidate

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Pfizer, BioNTech report ‘strong’ immune response in animals to COVID-19 mRNA vaccine candidate.Pfizer, BioNTech report ‘strong’ immune response in animals to COVID-19 mRNA vaccine candidate arlene.weintraub Wed, … Continue reading → #news

The Lancet Respiratory Medicine: Clinical trial finds inhaled immune response protein increases odds of recovery for hospitalised COVID-19 patients

Scienmag

Inhaled delivery of a formulation of a key protein involved in the immune response – interferon beta-1a – to hospitalised COVID-19 patients in the UK reduced the odds that they would develop severe disease or die from SARS CoV-2 infection.

NanoString’s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications

BioTech 365

NanoString’s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications NanoString’s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications Massachusetts General Hospital-led study … Continue reading → Business Wire

Novavax’s COVID-19 vaccine produces immune response in early study

Pharma Times

Vaccine was generally well-tolerated with only a few mild side-effects reported

Pfizer-BioNTech reports strong immune response in animals to its COVID-19 vaccine

The Pharma Data

Pfizer-BioNTech announced Wednesday that preliminary preclinical data from mouse and macaque monkey models showed a strong immune response from its mRNA COVID-19 vaccine. . Photo by Md. Tareq Aziz Touhid.

Early data shows Russia’s Sputnik V COVID-19 vaccine produces immune response

Pharma Phorum

A trial of Russia’s Sputnik V coronavirus vaccine has shown the jab produces an immune response, although the study was too small to produce conclusive findings, particularly on safety. The vaccine also produced a T-cell response within 28 days, a secondary outcome.

Delayed immune responses may drive COVID-19 mortality rates among men and the elderly

Scienmag

Immune responses to SARS-CoV-2 may depend on viral load and infection time course COVID-19 (SARS-CoV-2) infections tend to be more severe among older adults and males, yet the mechanisms underlying increased mortality in these two demographics are unknown.

TScan Therapeutics Announces Partnership with QIAGEN to Develop T Cell-Based Laboratory Test for Comprehensive COVID-19 Immune Response

BioTech 365

TScan Therapeutics Announces Partnership with QIAGEN to Develop T Cell-Based Laboratory Test for Comprehensive COVID-19 Immune Response TScan Therapeutics Announces Partnership with QIAGEN to Develop T Cell-Based Laboratory Test for Comprehensive COVID-19 Immune Response QIAGEN Secures Option to License Discoveries … Continue reading → Business Wire

#news #biotech Editing immune response could make gene therapy more effective

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Editing immune response could make gene therapy more effective.Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell.

J&J’s Single-Dose COVID-19 Vaccine Generates Strong Immune Response, Early Data Shows

BioSpace

The company posted an interim analysis of its Phase I/IIa trial that showed a single dose of JNJ-78436735 induced a strong neutralizing antibody response in nearly all participants and was well-tolerated

Early NK cell-mediated immune response may contribute to severe COVID-19

Scienmag

Credit: Markus Marcetic Researchers may have come one step closer toward understanding how the immune system contributes to severe COVID-19.

Vitamin E from palm oil useful in boosting immune response based on studies on liver cells

Scienmag

The article by Dr. Ahmed Atia and colleagues is published in Current Pharmaceutical Biotechnology, 2020 Palm oil contains abundant quantities of vitamin E compounds, which include tocopherols and tocotrienols. These compounds have anti-oxidant effects, which protect cells from damage from toxic chemical produced by metabolic processes. While tocopherol is a widely known and researched compound, […].

Diomics Announces Agreement With Department of Defense to Accelerate Development and Testing of Diocheck™ SARS-CoV-2 Immune Response Indicator Patch

BioTech 365

Simple Skin Patch Empowers Individuals to Monitor for Immune Response to Help Stop COVID-19 Spread SAN DIEGO–(BUSINESS WIRE)–Diomics, a San Diego-based biotech company, today announced that it has been awarded a $2,125,000 Medical Technology Enterprise Consortium (MTEC) Other Transaction Agreement … Continue reading → Business Wire

IL-21 protein a key part of immune response to central nervous system infections

Scienmag

— Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system. HERSHEY, Pa. The results of their recent study support further investigation into using IL-21 as a therapeutic agent for persistent central nervous system infections. CD4 T […]. Infectious Emerging Diseases Immunology/Allergies/Asthma Infectious/Emerging Diseases Medicine/Health

Sanford Burnham Prebys receives $3M NIH award for drugs that restore immune response to COVID-19

Scienmag

Scientists will study how SARS-CoV-19 hijacks the immune system and creates a ‘cytokine storm’ Credit: Sanford Burnham Prebys Medical Discovery Institute. Scientists at Sanford Burnham Prebys Medical Discovery Institute have received a $3 million grant from the National Institutes of Health (NIH) to study how SARS-CoV-19 weakens the immune system–and identify drugs to help infected […].

Finding clues to a successful immune response in the T cells of COVID-19 patients

Scienmag

While antibodies may fade fast, T cells appear to be long-lived and might confer lasting immunity. When news about a novel coronavirus switched from a chronicle of its progress in China to headlines about a worldwide COVID-19 pandemic, Gladstone Institutes scientist Nadia Roan, PhD, was in the midst of publishing several papers on T cells […]. Medicine & Health AIDS/HIV Biology Cell Biology Immunology/Allergies/Asthma Infectious/Emerging Diseases Virology

The Lancet: New polio vaccine against strain that threatens eradication is safe and generates immune response in adults, young children, and infants

Scienmag

Phase 2 trials in 1,200 adults, young children, and infants suggest new poliovirus vaccine may have the potential to overcome outbreaks caused by a mutated polio strain linked to the oral vaccine that typically circulates in areas of low immunisation coverage, and poses one of biggest barriers to eradication. Scientists have developed the first poliovirus […].

New Research Shows IBS Symptoms May be Caused by Gut Infections

XTalks

Researchers at KU Leuven in Belgium have found a potential mechanism underlying irritable bowel syndrome (IBS) that involves activation of immune cells primed by past gastrointestinal infections. Moreover, the response did not induce symptoms typical of a food allergy.

Cancer-focused biotech turns its tools to building a 2nd-generation coronavirus vaccine

Bio Pharma Dive

As worries about coronavirus mutations grow, Gritstone Oncology will work with the NIH to develop a shot capable of stimulating a broad immune response

Median Technologies: Promising Results on the Use of the IBiopsy® Platform in the Context of Measuring the Anti-tumor Immune Response

BioTech 365

The Lancet: Phase 2 trial of Oxford COVID-19 vaccine in healthy older adults finds it is safe and provokes immune response

Scienmag

Older adults are at a disproportionate risk of severe COVID-19 disease, so it is essential that any vaccine adopted for use against SARS-CoV-2 is effective in this group Peer-reviewed / Randomised Controlled Trial / People **There will be a UK Science Media Centre briefing at 10.15am UK time on Thursday 19th November about this study. […].