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Phase III trial shows gene therapy skin grafts help heal chronic wounds in blistering skin disease

Medical Xpress

Skin grafts genetically engineered from a patient's own cells can heal persistent wounds in people with an extremely painful dermatologic disease, a Stanford Medicine-led clinical trial has shown.

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Immune Markers of Anti-BCMA CAR-T in Myeloma

Scienmag

CAR-T cell therapies, by genetically engineering patients’ own T cells to express receptors specific to BCMA—a surface protein highly expressed on malignant plasma cells—have revolutionized treatment paradigms.

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Near-Infrared Activated Chemically Induced CRISPR

Scienmag

This novel CRISPR control method signifies the broader trend of integrating external physical stimuli with genetic engineering to achieve sophisticated bio-manipulation. This enhanced specificity underscores the clinical relevance and biosafety of the approach, fostering confidence in its future application.

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Decoding Barcodes Reveals the Earliest Blueprints of Our Cellular Origins

Scienmag

The essence of LoxCode lies in its ingenious use of DNA barcoding to uniquely mark each cell within a genetically engineered mouse. It includes comprehensive experimental validation using genetically engineered mouse models, illustrating the robustness and reproducibility of the barcoding technique. 2025.04.026.

In-Vivo 52
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Groundbreaking Study Advances Pig-to-Human Kidney Transplantation

Scienmag

Furthermore, refined genetic engineering of donor pigs, aimed at attenuating antigenicity based on pathways uncovered in this study, stands to significantly ameliorate host immune activation and rejection risks.

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Human CLOCK Boosts Neocortex Function Enhancements

Scienmag

The genetic engineering techniques employed to generate the HU mouse model underscore cutting-edge methodologies in modern neuroscience. By revealing CLOCK’s dualistic role in circadian rhythms and cortical maturation, the study invites a reevaluation of temporal regulation in brain function and its evolutionary pressures.

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Stanford Researchers Identify Missing Yew Tree Enzymes Crucial for Producing Common Cancer Drug

Scienmag

A Breakthrough in Taxol Biosynthesis: Unlocking the Enzymatic Blueprint for Scalable Cancer Drug Production Taxol, also known as paclitaxel, has stood as a cornerstone chemotherapy agent for decades, revolutionizing treatments for ovarian, breast, and lung cancers worldwide.