pharmaphorum

JULY 17, 2025

With the rise of advanced simulation and model-informed drug development (MIDD) techniques like digital twins, researchers can now transform their strategies by using models to duplicate biological systems.

Development 52

Development Drugs Trials Research 52

The Pharma Data

JUNE 24, 2025

This alliance aims to address mounting challenges in the development and commercialization of mAb therapies and gene therapies, particularly those involving AAV vectors. These standards are widely recognized by regulatory agencies such as the FDA and EMA for use in analytical method development, validation, and quality control.

Gene Therapy 40

Gene Therapy Gene Development Manufacturing 40

Bio Pharma Dive

JULY 8, 2025

The cell therapy developer, which raised nearly $500 million in 2023 on the promise of its CAR-T work, has floundered since a safety setback forced it to scrap its lead candidate.

Trials 161

Trials Development 161

Scienmag

JULY 1, 2025

This prospect opens exciting avenues for synthetic biology applications and the development of safer, more sophisticated gene therapies. Such developments accelerate the realization of personalized medicine, synthetic gene networks, and advanced biological research tools.

Gene Editing 59

Gene Editing Gene Gene Therapy Genomics 59

Rethinking Clinical Trials

JULY 1, 2025

The panelists proposed the development of more standardized materials for the consent process and other trial elements. Gohil described her research team’s commitment to developing a dissemination toolkit so people will understand how to approach implementation.

Trials 147

Trials Research Clinical Trials Clinical Trials 147

Scienmag

JUNE 23, 2025

A groundbreaking development in the early detection of hepatocellular carcinoma (HCC) has emerged from the halls of Wuhan Union Hospital at Huazhong University of Science and Technology. This is largely attributable to the fact that the disease frequently escapes detection until it advances to unmanageable stages.

Medicine 81

Medicine Antibody Research Engineer 81

Scienmag

JULY 3, 2025

However, the psychological sequelae, particularly the development of PTSD, are increasingly acknowledged as equally debilitating. undertakes the formidable task of identifying which factors among patients contribute most significantly to PTSD development, providing an evidence base for targeted mental health support.

Research 59

Research Development Medicine Drugs 59

Scienmag

JUNE 16, 2025

Scientists at King’s College London have developed a groundbreaking nanoneedle patch, a device embedded with tens of millions of microscopic needles, each thousands of times thinner than a human hair. He emphasizes that after over a decade of research on nanoneedles, this development marks the most significant breakthrough to date.

Scientist 59

Scientist Life Science Research Clinical Trials 59

Scienmag

JUNE 23, 2025

A groundbreaking development in neurosurgery has emerged with the FDA’s investment in an innovative AI-based technology designed to enhance the precision of brain mapping. Moving forward, it is crucial for both practitioners and technology developers to remain attentive to the implications presented by this novel software.

FDA Approval 52

FDA Approval Marketing Research Development 52

Scienmag

JULY 8, 2025

Beyond yellow fever, these findings have broad implications for live-attenuated vaccine development. Insights from this study empower scientists to refine this vaccine further or develop enhanced variants with improved immunogenic profiles or stability under varied climatic conditions.

Vaccine 59

Vaccine Vaccination Protein Genetics 59

The Pharma Data

JUNE 24, 2025

The remainder of the funding is structured as a credit facility, providing the company with the optionality to draw funds over time based on specific development and commercialization milestones. Its portfolio includes royalty interests in over 35 marketed and development-stage products across a range of therapeutic areas.

Medicine 40

Medicine Development Drugs Protein 40

Scienmag

JUNE 23, 2025

The study identifies the gene TATA-box binding protein associated factor 2 (TAF2) as a critical driver in hepatocyte survival and hepatocellular tumorigenesis, heralding new avenues for targeted therapy development. Dr. Sarkar’s research team applied rigorous preclinical models to underscore TAF2’s pivotal role in liver cancer progression.

Genetics 92

Genetics Scientist Gene Protein 92

Scienmag

JULY 11, 2025

In summation, the development of this contrastive deep learning framework marks a significant milestone in the evolution of high-content image-based phenotypic screening. The validation and extension toward other assay formats and biological contexts also provide exciting avenues for future exploration.

Compound Screening 59

Compound Screening Research Drugs Medicine 59

Scienmag

JULY 2, 2025

Central to this development is the marriage of biomechanical engineering with clinical neuroscience. Developing these computational models required sophisticated biomechanical simulations that account for tissue elasticity, tumor rigidity, and fluid dynamics within brain parenchyma.

In-Vivo 59

In-Vivo Engineer Research Doctor 59

Scienmag

JUNE 21, 2025

Such distinctions could help explain the divergent clinical presentations and treatment responses observed between the two disorders, suggesting that individualized diagnostic and therapeutic approaches might be developed based on interneuron molecular signatures. The translational potential of these findings cannot be overstated.

Gene Expression 80

Gene Expression Gene Regulation Research 80

pharmaphorum

JULY 15, 2025

An obesity therapy developed Hengrui Pharma and Kailera is being prepared for its first regulatory submission, in China

Development 85

Development 85

Scienmag

JUNE 22, 2025

The study illuminates the metabolic underpinnings of the developing cerebellum, a brain region central to motor control and cognitive functions, highlighting how early nutritional interventions can pave the way for improved neurological outcomes in vulnerable preterm populations. Article References: Basu, S.K., Ottolini, K.M., Kapse, K.J.

Research 59

Research Development Production Medicine 59

Scienmag

JUNE 17, 2025

The Notch signaling pathway, a highly conserved cell communication mechanism, is known for its essential role in vascular development and remodeling. Newborn infants affected by PPHN exhibit an abnormally high pulmonary vascular resistance, leading to impaired oxygen exchange and severe hypoxemia.

RNA 72

RNA Regulation DNA In-Vivo 72

Scienmag

JULY 3, 2025

In sum, the development of functional aligned mesenchymal stem cell sheets fabricated using micropatterned thermo-responsive culture surfaces represents a transformative stride forward. The method’s adaptability and ease of implementation further advocate for its rapid integration into preclinical and clinical research pipelines.

Engineer 92

Engineer Medicine In-Vivo Immune Response 92

Scienmag

JUNE 20, 2025

In a groundbreaking study published in the upcoming issue of Pediatric Research, researchers have unveiled novel insights into the heterogeneity of Kawasaki disease, particularly focusing on patients who develop coronary artery abnormalities. Clinical trials for emerging KD treatments may also benefit from this stratification.

Research 81

Research Immune Response Big Data Development 81

Scienmag

JULY 15, 2025

This metabolic paralysis leads to an effective bacterial eradication mechanism that circumvents the traditional routes targeted by antibiotics, potentially mitigating the development of further resistance. Beyond the bactericidal effects, the study reveals compelling immunomodulatory outcomes induced by this novel therapeutic strategy.

Antibody 59

Antibody Immune Response Bacteria In-Vivo 59

Scienmag

JUNE 19, 2025

Moreover, the platform’s ultrahigh colloidal stability could enable more flexible dosing schedules, patient-friendly administration routes, and the development of novel formulations such as injectable gels or inhalable aerosols. These adaptations could significantly improve patient compliance and clinical outcomes.

Drug Delivery 72

Drug Delivery Drugs Drug Delivery Systems Protein 72

Scienmag

JULY 18, 2025

This model closely mimics human pathological processes, involving proteinuria, developing crescentic lesions within glomeruli, and a relentless decline in kidney function. The spatial and temporal dynamics of this cluster highlighted its early and sustained involvement in disease evolution from acute injury to fully developed CGN.

Antibody 90

Antibody In-Vivo In-Vitro Research 90

Bio Pharma Dive

JULY 2, 2025

Industry veteran Catherine Owen Adams expects external innovation will be key to getting the brain-focused drug developer to “the next level.”

Development 141

Development Drugs 141

Scienmag

JULY 4, 2025

The novel insight that Cx43 reduces DNA repair capacity invites the intriguing hypothesis that modulating Cx43 levels or function might overcome or delay resistance development. These inhibitors have transformed the treatment landscape for patients with BRAF-mutant tumors; however, resistance invariably emerges.

DNA 100

DNA HR Protein Genotoxicity 100

Scienmag

JULY 4, 2025

At the heart of the research lies the notion that medical technologies are not merely static tools but complex knowledge products whose utility evolves as clinicians develop deeper understanding and more nuanced applications.

Research 59

Research Marketing Regulation Development 59

The Pharma Data

JUNE 16, 2025

Teva and Fosun Pharma Forge Strategic Partnership to Develop and Commercialize Innovative Anti-PD1-IL2 Therapy (TEV-56278) in Immuno-Oncology Teva Pharmaceutical Industries Ltd. This collaboration marks a significant step forward in global oncology drug development. and Shanghai Fosun Pharmaceutical (Group) Co.,

Development 40

Development Medicine Manufacturing Licensing 40

Pharma Times

JULY 10, 2025

The company is developing a single-injection formulation to simplify delivery and improve public health outcomes, especially in years when strain mismatches limit seasonal vaccine effectiveness.

Vaccine 81

Vaccine Vaccination Immune Response Trials 81

Scienmag

JUNE 18, 2025

In a groundbreaking new study, scientists have unveiled a comprehensive map detailing the mutagenesis sensitivity of human developmental enhancers in vivo, shedding unprecedented light on the intricate sequence architecture that governs gene regulation during human development.

In-Vivo 80

In-Vivo Gene Expression Gene DNA 80

Scienmag

JUNE 28, 2025

The multifaceted nature of lung development and injury in VLBW individuals necessitates careful interpretation of pulmonary function test results. Some VLBW individuals developed higher rates of mild to moderate asthma, which exacerbated the pulmonary challenges. The study by Jussinniemi et al.

Research 59

Research Development Genetics Scientist 59

Scienmag

JULY 3, 2025

Harnessing such data can accelerate the development of next-generation CAR-T therapies, potentially characterized by enhanced persistence, reduced toxicity, and the ability to overcome tumor immune evasion mechanisms. In sum, Atanackovic et al.’s

FDA Approval 85

FDA Approval Genetic Engineering Engineer Production 85

Scienmag

JULY 7, 2025

Among the myriad of tools developed, base editors (BEs) have emerged as transformative agents in enabling targeted nucleotide conversions without inducing double-strand breaks. Subject of Research : Development of highly precise cytosine base editors through engineering nucleic-acid-recognition specificity in TadA deaminase.

Genomics 59

Genomics Genome Genotype Engineer 59