Protein Misfolding Drug Discovery Summit

Pharma Phorum

With protein misfolding and aggregation prevalent in neurodegeneration, cancer, metabolic and ophthalmic diseases, the unmet clinical need presents huge opportunity to accelerate the discovery and translation of novel therapeutics to transform patient outcomes.

Protein fingerprinting in minutes

Scienmag

New technology enables ultrafast identification of COVID-19 biomarkers Credit: Photo: Arne Sattler/Charité Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes.

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Could High-Protein Iced Tea Be the Next Big Beverage Trend?

XTalks

One such fusion beverage is high-protein iced tea – a functional, refreshing beverage that has the potential to be the next big beverage trend. As an ingredient, whey protein comes with some challenges.

Protein misfolding specialist Gain nets $40m from IPO

Pharma Phorum

Gain Therapeutics has priced its initial public offering, raising more than $40 million for its computational drug discovery platform and pipeline of drugs for diseases associated with protein misfolding. . The post Protein misfolding specialist Gain nets $40m from IPO appeared first on.

Bringing bad proteins back into the fold

Scienmag

Study reveals mechanism used to regulate chaperone proteins, which guide other proteins into proper shapes Credit: UT Southwestern Medical Center DALLAS – Feb.

Oikos Introduces New Protein Products to Their Dairy Line

XTalks

Oikos has started the new year by introducing new protein-filled products to their dairy line. Their products provide a good source of protein, calcium and come in two snackable forms that boast up to 25 grams of protein. The protein ingredients market size was $38.02

A protein with a dual role: Both repair and mutation

Scienmag

Credit: © Terence Strick The Mfd protein repairs bacterial DNA, but can also, to scientists’ surprise, promote mutation. Using a specialized protein, […].

DNA 60

The Protein Society announces its 2021 award recipients

Scienmag

Credit: The Protein Society The Protein Society, the premier international society dedicated to supporting protein research, announces the winners of the 2021 Protein Society Awards, which will be conferred at the 35th Anniversary Symposium (virtual), July 7 – 14, 2021.

Scientists modeled protein behavior of archaeal viruses to crack protein folding mystery

Scienmag

Credit: FEFU press office Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature.

Inflammation-fighting protein could improve treatment of rheumatoid arthritis

Scienmag

– New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the […].

Designer protein patches boost cell signaling

Scienmag

Proteins engineered to form honeycomb structures can block uptake of receptors from the surface of cells Credit: Ian Haydon, UW Medicine Institute for Protein Design A new class of protein material that interacts with living cells without being absorbed by them can influence cell signaling, a new study shows.

Chaperone protein imbalance promotes toxic tau buildup in the aging brain

Scienmag

Lilly backs a biotech's spinout and places a small bet on protein degradation

Bio Pharma Dive

An alliance with BeyondSpring spinout Seed Therapeutics makes Eli Lilly the latest pharma company to dive into the fast-emerging drug research field

Deep dive into key COVID-19 protein is a step toward new drugs, vaccines

Scienmag

– Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein’s interactions with SARS-CoV-2 genetic material. Credit: OSU College of Science CORVALLIS, Ore.

A recipe for protein footprinting

Scienmag

Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins — that is, using advanced methods for investigating the structure and interactions of proteins within larger molecules. Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St.

How tangled proteins kill brain cells, promote Alzheimer’s, CTE

Scienmag

Study shines light on how tau aggregates promote neurodegeneration Look deep inside the brain of someone with Alzheimer’s disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you’ll find a common suspected culprit: stringy, hairball-like tangles of a protein called tau.

SLAS Discovery special issue “Advances in Protein Degradation” available now

Scienmag

Oak Brook, IL – The April edition of SLAS Discovery is a special issue on advances in protein degradation curated by guest editors M. Targeted protein degradation has generated interest within the drug discovery arena due to the inhibition of one particular function of a protein not […]. Paola Castaldi, Ph.D., and Stewart L. Fisher, Ph.D.

Large transporter protein linked to schizophrenia

Scienmag

Investigations of a cellular protein have uncovered a possible link with schizophrenia Credit: Mindy Takamiya/Kyoto University iCeMS Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens.

#news #biotech Programming proteins to turn cells into molecular computers

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Programming proteins to turn cells into molecular computers.A new method of breaking and fixing proteins could speed the development of sophisticated computer-like circuits in cells that will … Continue reading → #news

Visualisation reveals how a protein ‘hunkers down’ to conserve energy

Scienmag

Credit: University of Leeds A visualisation made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy.

Tracking receptor proteins can unveil molecular basis of memory and learning

Scienmag

Scientists from Japan employ a novel two-step method of labeling neurotransmitter receptor proteins to track their localization efficiently Credit: Shigeki Kiyonaka The neurons in our nervous system “talk” to each other by sending and receiving chemical messages called neurotransmitters.

New method targets disease-causing proteins for destruction

Scienmag

— Scientists at the University of Wisconsin-Madison have developed a way to use a cell’s own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs. Some cancers, for instance, are associated with abnormal proteins or an excess of normally harmless proteins. MADISON, Wis.

Hidden states of the COVID-19 spike protein

Scienmag

Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, […].

Protein tells developing cells to stick together

Scienmag

How tightly cells clump together, known as cell adhesion, appears to be enabled by a protein better known for its role in the immune system.

Blood vessel formation in damaged tissues with mussel adhesive protein

Scienmag

Credit: POSTECH Blood vessels deliver nutrients and oxygen to each organ in our body. They are difficult to completely restore to their original conditions once damaged by myocardial infarction or severe ischemic diseases.

A surprising protein player in diabetes

Scienmag

Credit: OIST A protein that’s common throughout the body plays a key role in regulating glucose levels, says new research conducted in the Cell Signal Unit at the Okinawa Institute of Science and Technology Graduate University (OIST) and Riken Center of Integrative Medical Sciences.

Brief encounters: How fleeting protein interactions shape health

Scienmag

Credit: University of Leeds The UK’s leading scientific academy – the Royal Society – has awarded one of its most prestigious research professorships to an academic at the University of Leeds, to develop new ways of ‘seeing the unseen’ – the way that proteins interact to shape or to destroy memories.

High-speed atomic force microscopy visualizes cell protein factories

Scienmag

Credit: Proceedings of the National Academy of Sciences Ribosomes are the complexes of ribonucleoproteins at the heart of protein synthesis in cells.

RNA holds the reins in bacteria: U-M researchers observe RNA controlling protein synthesis

Scienmag

Credit: Surajit Chatterjee To better understand how RNA in bacteria gives rise to protein–and along the way, target these processes in the design of new antibiotics–researchers are turning their attention to the unique way this process happens in bacteria.

RNA 60

A genetic shortcut to help visualize proteins at work

Scienmag

Each protein […].

Older women who ate more plant protein had lower risk of premature, dementia-related death

Scienmag

24, 2021 — Postmenopausal women who ate high levels of plant protein had lower risks of premature death, cardiovascular disease and dementia-related death compared with women who ate less plant proteins, according to new research published today in the Journal of the American Heart Association, an […]. Journal of the American Heart Association report DALLAS, Feb.

#news #biotech Inhibiting pancreatic cancer by exploiting a protein loophole

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Inhibiting pancreatic cancer by exploiting a protein loophole.Inhibiting pancreatic cancer by exploiting a protein loophole aliu Wed, 03/03/2021 – 05:24 from FierceBiotech: Biotech [link].

Finding a handle to bag the right proteins

Scienmag

Credit: © 2020 KAUST Purifying specific protein molecules from complex mixtures will become easier with a simpler way to detect a molecular “tag” commonly used as a handle to grab the proteins.

Technique permits convenient, precise optical imaging of individual proteins

Scienmag

Credit: Graphic by Shireen Dooling Often considered the workhorses of the body, proteins are among the most important biomolecules critical to life processes.

Dynamic model of SARS-CoV-2 spike protein reveals potential new vaccine targets

Scienmag

Blanc, Michael Gecht, Roberto Covino and Gerhard Hummer A new, detailed model of the surface of the SARS-CoV-2 spike protein reveals previously unknown vulnerabilities that could inform development of vaccines.

#news #biotech Supersaturation: The barrier between protein folding and misfolding

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Supersaturation: The barrier between protein folding and misfolding.Correct, or native, protein folding is essential for correct protein function. Protein misfolding can lead to the formation of amyloid … Continue reading → #news

Gates Biomanufacturing Facility reaches protein biologic manufacturing milestone

Scienmag

February 23, 2021) – The Gates Biomanufacturing Facility (GBF) has completed the manufacturing and release of a protein-based biologic under Good Manufacturing Practice for Phase 1 Investigational Drugs for first-in-human clinical trials. Manufacturing of this investigational, protein product demonstrates the GBF’s capacity to support both academic endeavors from Colorado’s university research centers and […]. Aurora, Colo.

Animation reveals secrets of critical tumour protein

Scienmag

Credit: WEHI, Australia The latest animation technology has revealed the molecular detail of how our bodies are protected from cancer by a key ‘tumour suppressor’ protein called p53. The new WEHI-TV animation visualises discoveries from more than 40 years of research to explain how the tumour suppressor protein p53 normally prevents cancer-causing changes in cells. […].

New protein nanobioreactor designed to improve sustainable bioenergy production

Scienmag

The study, published in Nature Communications, shows how bacterial protein ‘cages’ can be reprogrammed as nanoscale bioreactors for hydrogen production.

Prediction of protein disorder from amino acid sequence

Scienmag

Researchers from Aarhus University have developed a tool, ODiNPred, for prediction of the degree of structural order and disorder in proteins, by using machine learning together with experimental NMR data for hundreds of proteins.

Unique AI method for generating proteins will speed up drug development

Scienmag

Credit: Pixabay/Yen Strandqvist, Chalmers University of Technology Artificial Intelligence is now capable of generating novel, functionally active proteins, thanks to recently published work by researchers from Chalmers University of Technology, Sweden.

Oncotarget: A novel format for recombinant antibody-interleukin-2 fusion proteins

Scienmag

and Alessandra Villa – alessandra.villa@philogen.com Oncotarget recently published “A novel format for recombinant antibody-interleukin-2 fusion proteins […].

NanoString Launches GeoMx DSP Protein Assays for Next Generation Sequencing

BioTech 365

NanoString Launches GeoMx DSP Protein Assays for Next Generation Sequencing NanoString Launches GeoMx DSP Protein Assays for Next Generation Sequencing GeoMx Digital Spatial Profiler (DSP) Now Enables Multi-Analyte Spatial Analysis Using Both NGS and nCounter Read-outs SEATTLE–(BUSINESS WIRE)–NanoString Technologies, Inc.