Evaluating methods targeting Protein-Protein Interactions

Pharma Phorum

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins.

Lilly puts more money into protein degradation

Bio Pharma Dive

The pharma has struck its second research pact focused on drugs that break down harmful proteins in as many years, this time with California biotech Lycia Therapeutics

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Protein from the liver may cause Alzheimer’s disease in the brain

Scienmag

Amyloid protein made in the liver can cause neurodegeneration in the brain, according to a new study in the open-access journal PLOS Biology, by John Mamo of Curtin University in Bentley, Australia, and colleagues. Medicine & Health Alzheimers brain Disease Liver protein

Could High-Protein Iced Tea Be the Next Big Beverage Trend?

XTalks

One such fusion beverage is high-protein iced tea – a functional, refreshing beverage that has the potential to be the next big beverage trend. As an ingredient, whey protein comes with some challenges.

The dynamic tracking of tissue-specific secretory proteins​

Scienmag

Researchers have presented a method for profiling tissue-specific secretory proteins in live mice. Technology and Engineering dynamic proteins secretory tissuespecific trackingThis method is expected to be applicable to various tissues or disease models for investigating biomarkers or therapeutic targets involved in disease progression. This research was reported in Nature Communications on September 1. Credit: KAIST Researchers have presented a method for profiling […].

RXBAR Introduces its First Plant-Based Protein Bar

XTalks

RXBAR has introduced its first-ever plant-based protein bars, which fans have been highly anticipating. . Both bars are made with five ingredients: dates, nuts, oats and a blend of pea and almond protein.

Lilly taps Lycia for protein degrader tech in $1.6bn deal

Pharma Phorum

Eli Lilly has bolstered its position the fast-emerging area of protein degrader drugs, agreeing a $1.6 That’s a slightly different mechanism to some other degrader drugs that harness proteasomes – enzyme complexes found in cells – to dispose of proteins.

Protein fingerprinting in minutes

Scienmag

New technology enables ultrafast identification of COVID-19 biomarkers Credit: Photo: Arne Sattler/Charité Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes.

Oncotarget: Urine protein biomarkers of bladder cancer

Scienmag

These Oncotarget findings suggest that urine IL-1?, IL-1ra and IL-8 are useful indicators of bladder cancer.

Accurate protein structure prediction now accessible to all

Scienmag

Designer protein patches boost cell signaling

Scienmag

Proteins engineered to form honeycomb structures can block uptake of receptors from the surface of cells Credit: Ian Haydon, UW Medicine Institute for Protein Design A new class of protein material that interacts with living cells without being absorbed by them can influence cell signaling, a new study shows.

Freeze! Executioner protein caught in the act

Scienmag

Credit: WEHI Australia A new molecular ‘freeze frame’ technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells.

Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Scienmag

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington’s disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder. Scientists in the Buck Institute’s Ellerby lab have found that the targeting the protein […]. Experiments with small molecule have implications for research on aging.

Latest Data from Novavax COVID-19 Vaccine Trial Involving B.1.351 Variant Shared by Protein Vaccine Maker

XTalks

As Novavax awaits emergency use authorization (EUA) from the US Food and Drug Administration (FDA) for its protein-based COVID-19 vaccine NVX-CoV2373, the company shared new data this week on the vaccine’s efficacy against the South African B.1.351 variant.

Tracking proteins in the heart of cells

Scienmag

For the first time, a UNIGE team has been able to follow precisely the path taken by a protein within the cell, paving the way for the study of the transport and distribution network of vital elements necessary for its survival.

Newly discovered proteins protect against progression of diabetic kidney disease

Scienmag

Credit: Copyright Joslin Diabetes Center Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center that will be published 30th June in Science Translational Medicine.

A protein with a dual role: Both repair and mutation

Scienmag

Credit: © Terence Strick The Mfd protein repairs bacterial DNA, but can also, to scientists’ surprise, promote mutation. Using a specialized protein, […].

DNA 83

Protein misfolding specialist Gain nets $40m from IPO

Pharma Phorum

Gain Therapeutics has priced its initial public offering, raising more than $40 million for its computational drug discovery platform and pipeline of drugs for diseases associated with protein misfolding. . The post Protein misfolding specialist Gain nets $40m from IPO appeared first on.

Respiratory Syncytial Virus Fusion Protein (RSV F Protein) Drug Development Report 2021 – ResearchAndMarkets.com

BioTech 365

Respiratory Syncytial Virus Fusion Protein (RSV F Protein) Drug Development Report 2021 – ResearchAndMarkets.com Respiratory Syncytial Virus Fusion Protein (RSV F Protein) Drug Development Report 2021 – ResearchAndMarkets.com DUBLIN–(BUSINESS WIRE)–The “Respiratory Syncytial Virus Fusion Protein (RSV F Protein) – Drugs … Continue reading → Business Wire

The Protein Society announces its 2021 award recipients

Scienmag

Credit: The Protein Society The Protein Society, the premier international society dedicated to supporting protein research, announces the winners of the 2021 Protein Society Awards, which will be conferred at the 35th Anniversary Symposium (virtual), July 7 – 14, 2021.

Selecta and Cyrus Partner on Therapeutic Proteins for Immune Disorders

BioSpace

Selecta and Cyrus' partnership will pair Selecta’s immune-modulating ImmTOR platform with Cyrus’ ability to redesign protein therapeutics through its de novo computational approach

Protein in prostate cancer may inhibit tumor growth

Scienmag

Researchers identified the protein responsible for cancer’s aggressiveness Credit: Dorothy Kozlowski/UGA Prostate cancer is the second most common cancer among men, according to the American Cancer Society.

Bringing bad proteins back into the fold

Scienmag

Study reveals mechanism used to regulate chaperone proteins, which guide other proteins into proper shapes Credit: UT Southwestern Medical Center DALLAS – Feb.

Researchers develop first-in-class inhibitors against key leukemia protein

Scienmag

Approach opens a new avenue to study the biology of acute leukemia and for the development of new drugs Credit: Grembecka / Cierpicki Labs The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases.

Oikos Introduces New Protein Products to Their Dairy Line

XTalks

Oikos has started the new year by introducing new protein-filled products to their dairy line. Their products provide a good source of protein, calcium and come in two snackable forms that boast up to 25 grams of protein. The protein ingredients market size was $38.02

Gut hormone triggers craving for more proteins

Scienmag

Revelations from a fly study could improve our understanding of protein malnutrition in humans.

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) Drugs In Development, 2021 Research Report – ResearchAndMarkets.com

BioTech 365

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) Drugs In Development, 2021 Research Report – ResearchAndMarkets.com Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) Drugs In Development, 2021 Research Report – ResearchAndMarkets.com DUBLIN–(BUSINESS WIRE)–The “Bromodomain Containing Protein 4 (Protein HUNK1 … Continue reading → Business Wire

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Scienmag

This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas Credit: Correspondence to – Marco Timmer – marco.timmer@uk-koeln.de

Scientists modeled protein behavior of archaeal viruses to crack protein folding mystery

Scienmag

Credit: FEFU press office Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature.

Hidden states of the COVID-19 spike protein

Scienmag

Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, […].

Backyard chickens, rabbits, soybeans can meet household protein demand

Scienmag

Now, we have an idea how much protein people can grow in their backyards. The 2020 meat shortages led many to wonder what to eat for protein when supply chains are disrupted. Credit: Allison Mills/Michigan Tech In 2020, stores sold out of garden seed, coops and rabbit cages.

Pfizer Strengthens Cancer Standing with Protein Degrader Collaboration

BioSpace

This week the pharma giant announced a second collaboration agreement with Connecticut-based Arvinas to develop and commercialize its PROTAC estrogen receptor protein degrader

E-Protein Channel Blockers May Lead the Next Fight Against COVID-19

BioSpace

Research emerging from Israel identified eight already-approved compounds that inhibit the activity of the E-protein channels in the virus’s membrane

Researchers identify protein produced after stroke that triggers neurodegeneration

Scienmag

Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke.

New, neural network offers accurate prediction of protein folding

Scienmag

Researchers present RoseTTAFold – a neural network approach for protein modeling with accuracies near those of what DeepMind’s AlphaFold2 has achieved, according to a new study. Proteins are the building blocks of life […]. What’s more, the powerful new tool’s code, as well as a public server, are being made freely available to the scientific community. Technology and Engineering Biology Computer Science

A genetic shortcut to help visualize proteins at work

Scienmag

Each protein […].

LanC Like Protein 2 – Drugs Development & Competitive Landscape Report 2021: Testis Specific Adriamycin Sensitivity Protein or G Protein Coupled Receptor 69B or GPR69B or LANCL2 – ResearchAndMarkets.com

BioTech 365

LanC Like Protein 2 – Drugs Development & Competitive Landscape Report 2021: Testis Specific Adriamycin Sensitivity Protein or G Protein Coupled Receptor 69B or GPR69B or LANCL2 – ResearchAndMarkets.com LanC Like Protein 2 – Drugs Development & Competitive Landscape Report … Continue reading → Business Wire