Lilly puts more money into protein degradation

Bio Pharma Dive

The pharma has struck its second research pact focused on drugs that break down harmful proteins in as many years, this time with California biotech Lycia Therapeutics

Uncovering warped protein interactions in cancer

Scienmag

Scientists at Emory have revealed widespread distortions of a cell’s protein interaction machinery resulting from cancer-causing mutations. One reason why a mutation is tumorigenic is the altered network of protein-protein […]. Latest News cancer interactions protein Uncovering warpedThey developed a process resembling ground-penetrating radar, for its ability to map the hidden landscape of anticancer drug opportunities. The results are published in Cell.

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Artificial muscles made of proteins

Scienmag

Stefan Schiller and Dr. Matthias Huber from the University of Freiburg’s livMatS Cluster of Excellence have succeeded in developing a muscle solely on the basis of natural proteins. Latest News Artificial muscles proteins

Decoding protein assembly dynamics with artificial protein needles

Scienmag

Protein assembly is essential for the formation of ordered biological structures, but imagine engineering one! This is exactly what researchers at Tokyo Tech have now accomplished with protein needles. Biology Artificial assembly Decoding dynamics needles protein

New Machine Learning maps the potentials of proteins

Scienmag

The biotech industry is constantly searching for the perfect mutation, where properties from different proteins are synthetically combined to achieve a desired effect. Social & Behavioral Science learning machine maps potentials proteins

Newly discovered protein in fungus bypasses plant defenses

Scienmag

April 25, 2022—A protein that allows the fungus which causes white mold stem rot in more than 600 plant species to overcome plant defenses has been identified by a team of U.S. April 25, 2022—A protein that allows […]. Pullman, Wash.,

Unexpected protein could play role in common brain disorder

Scienmag

Scientists have known for years that amyloid fibrils — fibrous, ropelike structures formed by closely linked protein molecules — are present in the brains of patients with Alzheimer’s and Parkinson’s diseases and likely play a role in the progression of these disorders.

Deep learning reveals how proteins interact

Scienmag

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. Biology deep interact learning proteins reveals

Protein protects brain cells most impacted by glaucoma

Scienmag

March 1, 2022) — A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report. March 1, 2022) — A ubiquitous protein called sigma 1 receptor, […].

Identifying individual proteins using nanopores and supercomputers

Scienmag

The amount and types of proteins our cells produce tell us important details about our health and how our bodies work. But the methods we have of identifying and quantifying individual proteins are inadequate to the task.

AF2Complex: Researchers leverage deep learning to predict physical interactions of protein complexes

Scienmag

From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible. Protein function […]. Chemistry AND Physics AF2Complex complexes deep interactions learning leverage Physical predict protein researchers

How can a protein help us remember?

Scienmag

Studying fruit flies, they found that the Apterous (Ap) protein plays a crucial double role in retaining memories. Biology protein rememberTokyo, Japan – Researchers from Tokyo Metropolitan University have gained insights into the biochemistry of long-term memory.

Gene important in soybean protein content found after 30-year search

Scienmag

Soybeans outmatch all other legumes as the protein powerhouses of the plant kingdom, providing a key protein source for humans and livestock around the world. Social & Behavioral Science 30year Content gene important protein search SoybeanURBANA, Ill.

Protein structure offers clues to drug-resistance mechanism

Scienmag

CAMBRIDGE, MA — MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. Medicine & Health clues drugresistance mechanism offers protein structure

Air Protein: The Alt Meat Startup Making Plant-Based Protein Out of Thin Air

XTalks

California-based startup Air Protein developed an alt meat called Air Meat, which is made using microbes that turn recycled carbon dioxide (CO2) into protein. So, how does the company make alt protein out of thin air?

AI-designed protein awakens silenced genes, one by one

Scienmag

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Biology AIdesigned awakens Genes protein silenced

Oral Protein / Peptide-based Drugs: Addressing Key Unmet Needs Across Disease Indications

Roots Analysis

Orally administrable protein / peptide-based therapeutics offer several advantages including, effective treatment of numerous clinical conditions and degenerative disorders. Pipeline Overview of Oral Peptide and Protein-based Therapeutics. Oral Protein / Peptide-based Drugs.

Viral proteins join forces to lower plants’ defense ‘shields’

Scienmag

New research, led by Washington State University scientists, into how viral proteins interact and can be disabled holds promise to help plants defend themselves against viruses—and ultimately prevent crop losses. Latest News defense forces join plants proteins shields viral

Touting a new way to drug an all-important family of proteins, a startup launches with $100M

Bio Pharma Dive

Backed by some of biotech's most powerful investors, Septerna is looking to usher in the next chapter of medicines that act on G protein-coupled receptors

Study details changes in omicron’s spike protein

Scienmag

An international team of scientists has determined the precise structural changes in the spike protein of the omicron variant. Biology details omicrons protein Spike study

Disarming a blood-clotting protein prevents gum disease in mice

Scienmag

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

Genetically modified proteins convert carbon nanotube to programmable optoelectronic device

Scienmag

Russian researchers and their international collaborators have developed a full-function bioelectronic photocell using one molecule of a fluorescent protein attached to a carbon nanotube. When exposed to light, the system can change its electronic properties and operate either as a spotlight or memory cell depending on how the protein is attached to the tube. Technology and Engineering carbon convert device genetically modified Nanotube optoelectronic Programmable proteins

Targeted Protein Degradation Market: Riding on the Popularity of PROTAC, Market is set to Grow Exponentially

Roots Analysis

Over the years, the drug hunters have tried to target the tens of thousands of proteins responsible for sickness and health. In this article, we will evaluate the rising popularity of the concept of targeted protein degradation in overcoming the aforementioned challenges.

Could blocking or deleting a protein help prevent common oral cancers?

Scienmag

Biology blocking cancers common deleting oral prevent proteinThe most common head and neck cancer—oral squamous cell carcinoma—often starts off, as many other cancers do, quite innocently. Perhaps as a little white patch in the mouth or a small red bump on the gums.

Advanced microscopes help scientists understand how cells break down proteins

Scienmag

Proteins are the building blocks of all living things. A vast amount research takes place on how these proteins are made and what they do, from enzymes that carry out chemical reactions to messengers that transmit signals between cells.

Bone growth protein might help more newborns survive severe lung disorders

Scienmag

Biology bone disorders growth lung newborns protein severe surviveWhen babies are born with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), their skin starts to turn blue from the under-oxygenated blood in their systems.

Scientists discover potential key missing link protein bridging eukaryotes and prokaryotes

Scienmag

Biology Bridging discover eukaryotes key Link missing potential prokaryotes protein scientistsAll modern organisms fall into two classes, eukaryotes and prokaryotes.

Deep-learning algorithm aims to accelerate protein engineering

Scienmag

Machine learning algorithms assist in protein engineering by reducing the experimental burden of methods such as directed evolution, which involves multiple rounds of mutagenesis and high-throughput screening.

‘Stressed’ cells offer clues to eliminating build-up of toxic proteins in dementia

Scienmag

Now scientists have shown that the same may be true for cells, uncovering a newly-discovered mechanism that might help prevent the build-up of tangles of proteins commonly seen in dementia. Biology buildup cells clues dementia eliminating offer proteins stressed ToxicIt’s often said that a little stress can be good for you.

U of T researchers find trove of proteins that may influence cystic fibrosis

Scienmag

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

Plant Host Systems: A Novel Advancement in Protein Expression

Roots Analysis

Currently, a large number of plant-based proteins are being evaluated in clinical phases of development, including vaccine candidates against COVID 19 and multiple rare therapeutic disorders. The post Plant Host Systems: A Novel Advancement in Protein Expression appeared first on Blog.

Protein activity reveals new childhood ALL combination treatment strategy

Scienmag

Blocking a protein chain reaction makes childhood leukemia cells more sensitive to an existing targeted treatment, a new study shows. PhD-student Valentina Cordo’: ‘We’ve shown that looking at protein activity gives a more complete picture of the weaknesses in leukemia. Latest News activity Childhood combination protein reveals Strategy treatment

A diet rich in protein, zinc and niacin and low in saturated fat makes blood vessels more flexible, Israeli research suggests

Scienmag

A new study being presented at the European Congress on Obesity (ECO) in Maastricht, the Netherlands (4-7 May), has linked key nutrients, including protein, zinc and niacin, to improvements in heart health.

Intracellular temperature sensors: Protein complex exhibits temperature-sensitive activity

Scienmag

Osaka, Japan – One degree (Celsius) can make a difference: a team of investigators led by Osaka University has demonstrated regulation of a critical protein complex that occurs only at physiological temperature.

Ludwig Stanford study solves long-sought protein structure, shows how mutation drives blood cancers

Scienmag

Cancer blood cancers drives longsought Ludwig mutation protein shows solves Stanford structure study

Blueprint for proteins: How mRNA gets its final shape

Scienmag

Proteins need to interact in a complex manner for a so-called “messenger RNA” (mRNA) to be created in human cells from a precursor molecule. mRNA provides a blueprint for proteins; the first vaccines against the coronavirus are also based on mRNAs. Latest News Blueprint final mRNA proteins shapeA team from Martin Luther University Halle-Wittenberg (MLU) and the Max Planck Institute (MPI) […].

Plotting the placental protein NRK: Understanding the molecular evolution processes underlying placenta acquisition in eutherian ancestors

Scienmag

The molecular evolution of placental protein NRK and its function in regulating placental growth has finally been clarified by researchers from Tokyo Tech. Biology acquisition ancestors eutherian Evolution molecular NRK placenta placental Plotting processes protein underlying Understanding

PKU researchers harness higher order protein catenation for the development of artificial antibodies

Scienmag

Chemical topology is a unique dimension for protein engineering. Over the past few years, the discovery of topological nontrivial proteins in nature has already revealed their many potential functional benefits, such as enhanced thermal/mechanical/chemical stability.

Suffering from psoriasis? Blame this trio of proteins

Scienmag

Medicine & Health Blame proteins psoriasis Suffering trioLA JOLLA—About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes.

Protein can save the heart after cancer

Scienmag

Latest News cancer heart protein saveCancer treatment can be tough on the body, but for the patient to survive the cancer, it’s often necessary to go through with the treatment anyway. Some medications are effective against cancer, but one serious possible side effect is that they may trigger heart damage afterwards. There’s currently no method to reduce the risk of […].