Deep learning reveals how proteins interact

Scienmag

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. Biology deep interact learning proteins reveals

Identifying individual proteins using nanopores and supercomputers

Scienmag

The amount and types of proteins our cells produce tell us important details about our health and how our bodies work. But the methods we have of identifying and quantifying individual proteins are inadequate to the task.

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Lilly puts more money into protein degradation

Bio Pharma Dive

The pharma has struck its second research pact focused on drugs that break down harmful proteins in as many years, this time with California biotech Lycia Therapeutics

Evaluating methods targeting Protein-Protein Interactions

Pharma Phorum

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins.

Advanced microscopes help scientists understand how cells break down proteins

Scienmag

Proteins are the building blocks of all living things. A vast amount research takes place on how these proteins are made and what they do, from enzymes that carry out chemical reactions to messengers that transmit signals between cells.

PKU researchers harness higher order protein catenation for the development of artificial antibodies

Scienmag

Chemical topology is a unique dimension for protein engineering. Over the past few years, the discovery of topological nontrivial proteins in nature has already revealed their many potential functional benefits, such as enhanced thermal/mechanical/chemical stability.

Suffering from psoriasis? Blame this trio of proteins

Scienmag

Medicine & Health Blame proteins psoriasis Suffering trioLA JOLLA—About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes.

Deep-learning algorithm aims to accelerate protein engineering

Scienmag

Machine learning algorithms assist in protein engineering by reducing the experimental burden of methods such as directed evolution, which involves multiple rounds of mutagenesis and high-throughput screening.

Activation of a key protein that allows glioblastoma cells to complete apoptosis

Scienmag

Cancer activation apoptosis cells complete glioblastoma key proteinApoptosis is the mechanism by which defective cells promote their own death to protect the body. It is a complex process, with many stages, in which the different parts of the cell gradually degrade.

Study highlights role of disordered protein interactions in gene expression

Scienmag

Latest News Disordered expression gene highlights interactions protein role studyA team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered a new piece of the puzzle of how gene expression is orchestrated. Published in the journal Science, the findings reveal a novel mechanism that coordinates the assembly of components inside cells that control gene expression. The mechanism […].

Nanoscale ‘computer’ controls function of protein, influences cell behavior

Scienmag

Now, for the first time, researchers at Penn State have produced a nanocomputing agent that can control the function of a particular protein that is involved in cell […]. Space & Planetary Science Behavior cell computer controls function influences nanoscale proteinUNIVERSITY PARK, Pa. — The creation of nanoscale computers for use in precision health care has long been a dream of many scientists and health care providers.

Blood plasma protein fibrinogen interacts directly with nerve cells to cause brain inflammation

Scienmag

8, 2021) — Neuroinflammatory diseases, including Alzheimer’s disease and traumatic brain injury, have been linked to deposits of a tough protein known as fibrin, derived from the blood clotting factor fibrinogen. TAMPA, Fla (Nov.

Study reveals a protein’s key contribution to heterogeneity of neurons

Scienmag

Latest News contribution heterogeneity key Neurons proteins reveals study

Scientists show how mucus protein contributes to worsening COPD, asthma, lung conditions

Scienmag

CHAPEL HILL, NC – Mucus is an essential protective layer of gel-like liquid composed largely of proteins called mucins throughout our airways. Medicine & Health asthma conditions contributes COPD lung mucus protein scientists show worsening

New COVID-19 vaccines could target replication proteins

Pharma Times

Researchers have said that next generation vaccines for COVID-19 should aim to induce a response against ‘replication proteins

Why Maple Leaf Foods is Reevaluating its Plant Protein Business

XTalks

Maple Leaf Foods, one of Canada’s largest pork and poultry processors, announced yesterday it would be reevaluating its plant-based protein business. Its meat protein sales grew to $1.15 Meanwhile, its plant protein sales dipped to $48 million compared with $51.4

Modified protein from rattlesnake venom permits development of drug to modulate blood clotting

Scienmag

Latest News blood clotting development Drug modified modulate permits protein rattlesnake venomThe research is part of two projects supported by FAPESP (2011/23236-4, and 2015/17286-0), as well as a PhD scholarship and a postdoctoral scholarship. The article “Towards toxin PEGylation: The example of rCollinein-1, a snake venom thrombin-like enzyme, as a PEGylated biopharmaceutical prototype” is at: www.sciencedirect.com/science/article/abs/pii/S0141813021019164.

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Could High-Protein Iced Tea Be the Next Big Beverage Trend?

XTalks

One such fusion beverage is high-protein iced tea – a functional, refreshing beverage that has the potential to be the next big beverage trend. As an ingredient, whey protein comes with some challenges.

Neuroinflammation protein linked to worse survival in men with glioblastoma

Scienmag

Social & Behavioral Science glioblastoma linked men neuroinflammation protein survival worse

Powerful technique allows scientists to study how proteins change shape inside cells

Scienmag

CHAPEL HILL, NC – Understanding how proteins bend, twist, and shape-shift as they go about their work in cells is enormously important for understanding normal biology and diseases. Atmospheric Science cells change powerful proteins scientists shape study technique

UK biotech Dunad inks $1.3bn Novartis deal for its protein degraders

Pharma Phorum

In only its second year of operations, Cambridge, UK startup Dunad Therapeutics has already attracted a big pharma partner for its protein degradation platform. The post UK biotech Dunad inks $1.3bn Novartis deal for its protein degraders appeared first on.

Protein Misfolding Drug Discovery Summit

Pharma Phorum

With protein misfolding and aggregation prevalent in neurodegeneration, cancer, metabolic and ophthalmic diseases, the unmet clinical need presents huge opportunity to accelerate the discovery and translation of novel therapeutics to transform patient outcomes.

RXBAR Introduces its First Plant-Based Protein Bar

XTalks

RXBAR has introduced its first-ever plant-based protein bars, which fans have been highly anticipating. . Both bars are made with five ingredients: dates, nuts, oats and a blend of pea and almond protein.

Protein from the liver may cause Alzheimer’s disease in the brain

Scienmag

Amyloid protein made in the liver can cause neurodegeneration in the brain, according to a new study in the open-access journal PLOS Biology, by John Mamo of Curtin University in Bentley, Australia, and colleagues. Medicine & Health Alzheimers brain Disease Liver protein

Protein misfolding specialist Gain nets $40m from IPO

Pharma Phorum

Gain Therapeutics has priced its initial public offering, raising more than $40 million for its computational drug discovery platform and pipeline of drugs for diseases associated with protein misfolding. . The post Protein misfolding specialist Gain nets $40m from IPO appeared first on.

Lilly taps Lycia for protein degrader tech in $1.6bn deal

Pharma Phorum

Eli Lilly has bolstered its position the fast-emerging area of protein degrader drugs, agreeing a $1.6 That’s a slightly different mechanism to some other degrader drugs that harness proteasomes – enzyme complexes found in cells – to dispose of proteins.

Better Bagel: The Low-Carb, High-Protein Bagel That’s “Changing the Grain”

XTalks

While it looks and tastes like a normal one, the Better Bagel has the same carbohydrate content as two slices of bananas, the same sugar content as a stalk of celery and the same protein content as four eggs. grams of protein.

Protein fingerprinting in minutes

Scienmag

New technology enables ultrafast identification of COVID-19 biomarkers Credit: Photo: Arne Sattler/Charité Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes.

The dynamic tracking of tissue-specific secretory proteins?

Scienmag

Researchers have presented a method for profiling tissue-specific secretory proteins in live mice. Technology and Engineering dynamic proteins secretory tissuespecific trackingThis method is expected to be applicable to various tissues or disease models for investigating biomarkers or therapeutic targets involved in disease progression. This research was reported in Nature Communications on September 1. Credit: KAIST Researchers have presented a method for profiling […].

Oncotarget: Urine protein biomarkers of bladder cancer

Scienmag

These Oncotarget findings suggest that urine IL-1?, IL-1ra and IL-8 are useful indicators of bladder cancer.

Designer protein patches boost cell signaling

Scienmag

Proteins engineered to form honeycomb structures can block uptake of receptors from the surface of cells Credit: Ian Haydon, UW Medicine Institute for Protein Design A new class of protein material that interacts with living cells without being absorbed by them can influence cell signaling, a new study shows.

Kymera’s Protein Degraders are Expanding the Druggable Universe

BioSpace

The ability to utilize one protein degrader against a whole host of diseases drives Kymera’s strategy when choosing protein targets

Freeze! Executioner protein caught in the act

Scienmag

Credit: WEHI Australia A new molecular ‘freeze frame’ technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells.

Accurate protein structure prediction now accessible to all

Scienmag

Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Scienmag

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington’s disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder. Scientists in the Buck Institute’s Ellerby lab have found that the targeting the protein […]. Experiments with small molecule have implications for research on aging.

Tracking proteins in the heart of cells

Scienmag

For the first time, a UNIGE team has been able to follow precisely the path taken by a protein within the cell, paving the way for the study of the transport and distribution network of vital elements necessary for its survival.

A protein with a dual role: Both repair and mutation

Scienmag

Credit: © Terence Strick The Mfd protein repairs bacterial DNA, but can also, to scientists’ surprise, promote mutation. Using a specialized protein, […].

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The Protein Society announces its 2021 award recipients

Scienmag

Credit: The Protein Society The Protein Society, the premier international society dedicated to supporting protein research, announces the winners of the 2021 Protein Society Awards, which will be conferred at the 35th Anniversary Symposium (virtual), July 7 – 14, 2021.

Bringing bad proteins back into the fold

Scienmag

Study reveals mechanism used to regulate chaperone proteins, which guide other proteins into proper shapes Credit: UT Southwestern Medical Center DALLAS – Feb.

Avilar Debuts to Pioneer Extracellular Protein Degradation

BioSpace

Avilar Therapeutics officially joined the game with $60 million in seed financing from RA Capital Management

Newly discovered proteins protect against progression of diabetic kidney disease

Scienmag

Credit: Copyright Joslin Diabetes Center Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center that will be published 30th June in Science Translational Medicine.

Researchers develop first-in-class inhibitors against key leukemia protein

Scienmag

Approach opens a new avenue to study the biology of acute leukemia and for the development of new drugs Credit: Grembecka / Cierpicki Labs The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases.

Protein in prostate cancer may inhibit tumor growth

Scienmag

Researchers identified the protein responsible for cancer’s aggressiveness Credit: Dorothy Kozlowski/UGA Prostate cancer is the second most common cancer among men, according to the American Cancer Society.