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Lilly puts more money into protein degradation

Bio Pharma Dive

The pharma has struck its second research pact focused on drugs that break down harmful proteins in as many years, this time with California biotech Lycia Therapeutics

Protein 232
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Evaluating methods targeting Protein-Protein Interactions

Pharma Phorum

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins.

Protein 101
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Feinstein Institutes researchers discover new protein for sepsis treatment

Pharmaceutical Technology

Researchers at the Feinstein Institutes for Medical Research have discovered a new protein that can be a potential therapeutic target for lethal sepsis. The post Feinstein Institutes researchers discover new protein for sepsis treatment appeared first on Pharmaceutical Technology.

Protein 130
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With $81M, Entact Bio takes a new approach to fixing helpful proteins

Bio Pharma Dive

Entact Bio aims to develop medicines that can enhance helpful proteins, rather than block harmful ones, a twist on the usual drugmaking playbook

Protein 178
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Gladstone and UCSF scientists discover BET protein role in Covid-19

Pharmaceutical Technology

Researchers at Gladstone Institutes and UC San Francisco (UCSF) have discovered in a study that bromodomain and extraterminal (BET) proteins are vital for the body to fight Covid-19 infection. . These findings indicated that BET proteins have a vital role in enabling and combating Covid-19.

Protein 228
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Protein folding in times of oxygen deficiency

Scienmag

Proteins often consist of hundreds or thousands of individual parts, the amino acids. However, protein molecules would not be able to fulfill their task as a long filament flapping back and forth. Chemistry AND Physics deficiency folding oxygen protein times

Protein 69
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Decoding protein assembly dynamics with artificial protein needles

Scienmag

Protein assembly is essential for the formation of ordered biological structures, but imagine engineering one! This is exactly what researchers at Tokyo Tech have now accomplished with protein needles. Biology Artificial assembly Decoding dynamics needles protein

Protein 70
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Artificial muscles made of proteins

Scienmag

Stefan Schiller and Dr. Matthias Huber from the University of Freiburg’s livMatS Cluster of Excellence have succeeded in developing a muscle solely on the basis of natural proteins. Latest News Artificial muscles proteins

Protein 66
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AbbVie, targeting a well-known protein family, expands a partnership into neuroscience

Bio Pharma Dive

It’s the second deal in as many years between AbbVie and Sosei Heptares, which together have been trying to develop drugs that target so-called G protein-coupled receptors

Protein 223
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Deep learning reveals how proteins interact

Scienmag

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. Biology deep interact learning proteins reveals

Protein 77
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Protein supplement helps control Type 2 diabetes

Scienmag

Drinking a small amount of whey protein before meals has been shown to help people with type 2 diabetes control their blood sugars. Social & Behavioral Science control Diabetes helps protein supplement type

Protein 68
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Lilly partners with Sosei to develop drugs aimed at a key family of proteins

Bio Pharma Dive

The pharma will pay Sosei $37 million upfront to discover new candidates for diabetes and metabolic diseases that target G protein-coupled receptors

Protein 146
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Identifying individual proteins using nanopores and supercomputers

Scienmag

The amount and types of proteins our cells produce tell us important details about our health and how our bodies work. But the methods we have of identifying and quantifying individual proteins are inadequate to the task.

Protein 75
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How can a protein help us remember?

Scienmag

Studying fruit flies, they found that the Apterous (Ap) protein plays a crucial double role in retaining memories. Biology protein rememberTokyo, Japan – Researchers from Tokyo Metropolitan University have gained insights into the biochemistry of long-term memory.

Protein 76
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Balancing protein in your diet could improve water quality

Scienmag

Balancing how much protein you eat with the amount your body needs could reduce nitrogen releases to aquatic systems in the U.S. Credit: Courtesy Maya Almaraz Balancing how much protein you eat with […]. Technology and Engineering Balancing diet improve protein quality water

Protein 74
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CDC backs Novavax's protein-based vaccine for COVID-19

Bio Pharma Dive

Health officials argue a new type of shot could help to persuade unvaccinated people, although some surveys suggest that might not be the case

Protein 236
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Touting a new way to drug an all-important family of proteins, a startup launches with $100M

Bio Pharma Dive

Backed by some of biotech's most powerful investors, Septerna is looking to usher in the next chapter of medicines that act on G protein-coupled receptors

Protein 253
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Unexpected protein could play role in common brain disorder

Scienmag

Scientists have known for years that amyloid fibrils — fibrous, ropelike structures formed by closely linked protein molecules — are present in the brains of patients with Alzheimer’s and Parkinson’s diseases and likely play a role in the progression of these disorders.

Protein 77
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Without ‘work-life balance,’ this protein may promote disease

Scienmag

COLUMBUS, Ohio – A family of proteins that have a role in ensuring many types of cells move and maintain their shape may promote disease when they act like workaholics and disrupt the cellular environment, new research suggests. Latest News balance Disease promote protein worklife

Protein 68
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Gene important in soybean protein content found after 30-year search

Scienmag

Soybeans outmatch all other legumes as the protein powerhouses of the plant kingdom, providing a key protein source for humans and livestock around the world. Social & Behavioral Science 30year Content gene important protein search SoybeanURBANA, Ill.

Protein 75
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Newly discovered protein in fungus bypasses plant defenses

Scienmag

April 25, 2022—A protein that allows the fungus which causes white mold stem rot in more than 600 plant species to overcome plant defenses has been identified by a team of U.S. April 25, 2022—A protein that allows […]. Pullman, Wash.,

Protein 73
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Oral Protein / Peptide-based Drugs: Addressing Key Unmet Needs Across Disease Indications

Roots Analysis

Orally administrable protein / peptide-based therapeutics offer several advantages including, effective treatment of numerous clinical conditions and degenerative disorders. Pipeline Overview of Oral Peptide and Protein-based Therapeutics. Oral Protein / Peptide-based Drugs.

Protein 52
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Disarming a blood-clotting protein prevents gum disease in mice

Scienmag

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

Protein 78
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New Machine Learning maps the potentials of proteins

Scienmag

The biotech industry is constantly searching for the perfect mutation, where properties from different proteins are synthetically combined to achieve a desired effect. Social & Behavioral Science learning machine maps potentials proteins

Protein 73
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Uncovering warped protein interactions in cancer

Scienmag

Scientists at Emory have revealed widespread distortions of a cell’s protein interaction machinery resulting from cancer-causing mutations. One reason why a mutation is tumorigenic is the altered network of protein-protein […]. Latest News cancer interactions protein Uncovering warpedThey developed a process resembling ground-penetrating radar, for its ability to map the hidden landscape of anticancer drug opportunities. The results are published in Cell.

Protein 53
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Protein protects brain cells most impacted by glaucoma

Scienmag

March 1, 2022) — A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report. March 1, 2022) — A ubiquitous protein called sigma 1 receptor, […].

Protein 68
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BETting on COVID-19: Study probes role of BET proteins in coronavirus infection

Scienmag

SAN FRANCISCO, CA—A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and extraterminal (BET) proteins, might be a way to fight COVID-19. Biology BET betting coronavirus COVID19 infection probes proteins role study

Protein 73
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Protein structure offers clues to drug-resistance mechanism

Scienmag

CAMBRIDGE, MA — MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. Medicine & Health clues drugresistance mechanism offers protein structure

Protein 72
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Viral proteins join forces to lower plants’ defense ‘shields’

Scienmag

New research, led by Washington State University scientists, into how viral proteins interact and can be disabled holds promise to help plants defend themselves against viruses—and ultimately prevent crop losses. Latest News defense forces join plants proteins shields viral

Protein 73
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AI-designed protein awakens silenced genes, one by one

Scienmag

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Biology AIdesigned awakens Genes protein silenced

Protein 72
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Air Protein: The Alt Meat Startup Making Plant-Based Protein Out of Thin Air

XTalks

California-based startup Air Protein developed an alt meat called Air Meat, which is made using microbes that turn recycled carbon dioxide (CO2) into protein. So, how does the company make alt protein out of thin air?

Protein 82
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Study details changes in omicron’s spike protein

Scienmag

An international team of scientists has determined the precise structural changes in the spike protein of the omicron variant. Biology details omicrons protein Spike study

Protein 70
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Advanced microscopes help scientists understand how cells break down proteins

Scienmag

Proteins are the building blocks of all living things. A vast amount research takes place on how these proteins are made and what they do, from enzymes that carry out chemical reactions to messengers that transmit signals between cells.

Protein 71
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Imaging solves mystery of how large HIV protein functions to form infectious virus

Scienmag

Now, a team of scientists from the Salk Institute and Rutgers University have for the first time determined the molecular structure of HIV Pol, a protein that plays […]. Medicine & Health form functions HIV imaging infectious large mystery protein solves virus

Protein 76
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Bioproduction Breakthrough: New method for developing Pichia pastoris yeast strains with high productivity of useful proteins

Scienmag

A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (1) in order to increase its secretory production of useful proteins (2).

Protein 76
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New insights of how the HIV-1 assembles and incorporates the Env protein

Scienmag

Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag’s N-terminal matrix domain. BIRMINGHAM, Ala.

Protein 73
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Suffering from psoriasis? Blame this trio of proteins

Scienmag

Medicine & Health Blame proteins psoriasis Suffering trioLA JOLLA—About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes.

Protein 79
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Intracellular temperature sensors: Protein complex exhibits temperature-sensitive activity

Scienmag

Osaka, Japan – One degree (Celsius) can make a difference: a team of investigators led by Osaka University has demonstrated regulation of a critical protein complex that occurs only at physiological temperature.

Protein 73
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AF2Complex: Researchers leverage deep learning to predict physical interactions of protein complexes

Scienmag

From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible. Protein function […]. Chemistry AND Physics AF2Complex complexes deep interactions learning leverage Physical predict protein researchers

DNA 70
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Deep-learning algorithm aims to accelerate protein engineering

Scienmag

Machine learning algorithms assist in protein engineering by reducing the experimental burden of methods such as directed evolution, which involves multiple rounds of mutagenesis and high-throughput screening.

Protein 66
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Genetically modified proteins convert carbon nanotube to programmable optoelectronic device

Scienmag

Russian researchers and their international collaborators have developed a full-function bioelectronic photocell using one molecule of a fluorescent protein attached to a carbon nanotube. When exposed to light, the system can change its electronic properties and operate either as a spotlight or memory cell depending on how the protein is attached to the tube. Technology and Engineering carbon convert device genetically modified Nanotube optoelectronic Programmable proteins

Protein 59
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Stress protein in fibroblasts may be a good target for future cancer drugs, Penn study finds

Scienmag

Cancer cancer Drugs fibroblasts finds future good Penn protein stress study target

Protein 72
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U of T researchers find trove of proteins that may influence cystic fibrosis

Scienmag

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

Protein 75