Protein Misfolding Drug Discovery Summit

Pharma Phorum

With protein misfolding and aggregation prevalent in neurodegeneration, cancer, metabolic and ophthalmic diseases, the unmet clinical need presents huge opportunity to accelerate the discovery and translation of novel therapeutics to transform patient outcomes.

Hidden states of the COVID-19 spike protein

Scienmag

Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, […].

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Oncotarget: A novel format for recombinant antibody-interleukin-2 fusion proteins

Scienmag

and Alessandra Villa – alessandra.villa@philogen.com Oncotarget recently published “A novel format for recombinant antibody-interleukin-2 fusion proteins […].

A surprising protein player in diabetes

Scienmag

Credit: OIST A protein that’s common throughout the body plays a key role in regulating glucose levels, says new research conducted in the Cell Signal Unit at the Okinawa Institute of Science and Technology Graduate University (OIST) and Riken Center of Integrative Medical Sciences.

Technique permits convenient, precise optical imaging of individual proteins

Scienmag

Credit: Graphic by Shireen Dooling Often considered the workhorses of the body, proteins are among the most important biomolecules critical to life processes.

Finding a handle to bag the right proteins

Scienmag

Credit: © 2020 KAUST Purifying specific protein molecules from complex mixtures will become easier with a simpler way to detect a molecular “tag” commonly used as a handle to grab the proteins.

Dueling proteins give shape to plants

Scienmag

Research led by University of Pennsylvania biologists reveals an antagonistic relationship behind flower development Credit: Wagner laboratory In an elegant choreography, plants take cues from their environment and channel them into flowers, roots, or branches.

Global Protein Kinase Inhibitors in Oncology Analytical Handbook 2020 – ResearchAndMarkets.com

BioTech 365

DUBLIN–(BUSINESS WIRE)–The “Protein Kinase Inhibitors in Oncology: Analytical Tool” report has been added to ResearchAndMarkets.com’s offering. Protein Kinase Inhibitors in Oncology: Analytical Tool is the must have handbook for any business developer, BI/CI operative or clinical developer who needs to … Continue reading → Business Wire

#news #biotech Improving protein digestibility in sorghum

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Improving protein digestibility in sorghum.Sorghum, a common food item in regions of Africa and Asia, has one missing puzzle piece. Protein digestibility, which researchers … Continue reading → #news

Designed antiviral proteins inhibit SARS-CoV-2 in the lab

Scienmag

Computer design of synthetic proteins is creating potent, stable antivirals that block infection at least as well as monoclonal antibodies Credit: Ian Haydon/UW Medicine Institute for Protein Design Computer-designed small proteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19.

A bifidobacterial protein that can reduce inflammation in COVID-19 found by a RUDN geneticist

Scienmag

Global Protein Expression Market- Featuring Accelagen Inc., Agilent Technologies Inc., and Becton, Dickinson and Co. Among Others

BioTech 365

LONDON–(BUSINESS WIRE)–#GlobalProteinExpressionMarket–The protein expression market is poised to grow by USD 1.63 The report on the protein expression market provides a holistic update, market size and … Continue reading → Business Wire

Immune protein orchestrates daily rhythm of squid-bacteria symbiotic relationship

Scienmag

Credit: Eric Koch Nearly every organism hosts a collection of symbiotic microbes–a microbiome. It is now recognized that microbiomes are major drivers of health in all animals, including humans, and that these symbiotic systems often exhibit strong daily rhythms.

Association Between Plant and Animal Protein Intake and Overall and Cause-Specific Mortality

JAMA Internal Medicine

To provide evidence for public health recommendations regarding dietary modifications in choice of protein sources that may promote long-term health outcomes, this cohort study assesses overall mortality and cause-specific mortality associated with consumption of plant protein and animal protein in a large US population with 16 years of follow-up

COVID-19 Pandemic Impact on Global Protein Therapeutics Market 2020-2024 | Technavio

BioTech 365

Increased Demand for MAbs will drive the market growth during the forecast period LONDON–(BUSINESS WIRE)–#GlobalProteinTherapeuticsMarket–The protein therapeutics market is expected to register a CAGR of over 7% during 2020-2024, as per the latest research report by Technavio.

Protein that keeps immune system from freaking out could form basis for new therapeutics

Scienmag

Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction, supports a mechanism critical for survival in mouse models of sepsis and colitis Credit: UC San Diego Health Sciences The immune response to infections is a delicate balance.

Shimadzu BioSpec-1601 UV-1601 DNA / Protein / Enzyme Analyzer

BioTech 365

$207.50 (6 Bids)End Date: Tuesday Aug-18-2020 8:06:33 PDTBid now | Add to watch list Biotech365 : Shimadzu BioSpec-1601 UV-1601 DNA / Protein / Enzyme Analyzer BioMarketplace You want to propose your products or a Biotech Company, a Biotech Tool or … Continue reading → #BioMarketplace #BioMarketplace_US #Shimadzu

DNA 40

#news #biotech RAP tag: A new protein purification approach

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: RAP tag: A new protein purification approach.Whether it’s our diets, building strength, or as part of medical advancements, it is no secret that proteins form an important … Continue reading → #news

Phytoplasma effector proteins devastate host plants through molecular mimicry

Scienmag

Phytoplasma are a type of bacteria that live within the cells and cause devastating diseases with damaging effects. For example, in many cases plants infected with phytoplasma are no longer able to develop flowers. These plants have actually been described as “zombies,” since they allow the reproduction of phytoplasma but are unable to reproduce themselves […].

Lumpy proteins stiffen blood vessels of the brain

Scienmag

Spotlight on a new risk factor for vascular dementia Deposits of a protein called “Medin”, which manifest in virtually all older adults, reduce the elasticity of blood vessels during aging and hence may be a risk factor for vascular dementia.

#news #biotech How a protein promotes pancreatic cancer metastasis

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: How a protein promotes pancreatic cancer metastasis.How a protein promotes pancreatic cancer metastasis aliu Fri, 08/07/2020 – 05:54 from FierceBiotech: Biotech [link].

#news #biotech Prediction of protein disorder from amino acid sequence

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Prediction of protein disorder from amino acid sequence.Structural disorder is vital for proteins’ function in diverse biological processes.

#news #biotech Plant protein discovery could reduce need for fertilizer

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Plant protein discovery could reduce need for fertilizer.Researchers have discovered how a protein in plant roots controls the uptake of minerals and water, a finding which could … Continue reading → #news

Monte Rosa Therapeutics raises $96m to develop protein-degrading molecules

The Pharma Data

Monte Rosa Therapeutics has raised $96m in Series B financing to support further develop of its pipeline of small-molecule protein degraders. The company, which was originally formed as a spinout from Cancer Research UK-funded research at the Institute of Cancer Research, specialises in targeted protein degradation. ICR and Cancer Research UK spinout closes Series B financing.

Ligand Buys Pfenex in $516 Million Deal to Access Protein Production Platform

BioSpace

Pfenex’ proprietary protein production platform, Pfenex Expression Technology, is used to improve existing treatments and create novel therapies

Genetic study of proteins is a breakthrough in drug development for complex diseases

Scienmag

Credit: Dr Jie Zheng An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases.

Decreased protein degradation in cerebellum leads to motor dysfunction

Scienmag

Researchers identify role of protein in development of new hearing hair cells

Scienmag

Finding could lead to future treatments for hearing loss Credit: University of Maryland School of Medicine Researchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells.

COVID-19 Recovery Analysis: Protein Expression Market | Increasing Advances in Proteomics Research to Boost Market Growth | Technavio

BioTech 365

LONDON–(BUSINESS WIRE)–#GlobalProteinExpressionMarket–Technavio has been monitoring the protein expression market and it is poised to grow by USD 1.63

Brain protein linked to seizures, abnormal social behaviors

Scienmag

UC Riverside mouse study focused on neurons in the hippocampus Credit: Ethell lab, UC Riverside.

Imaging method highlights new role for cellular “skeleton” protein

Scienmag

Molecules of actin help control the division of mitochondria, with implications for disease Credit: Salk Institute/Waitt Advanced Biophotonics Center LA JOLLA–(August 10, 2020) While your skeleton helps your body to move, fine skeleton-like filaments within your cells likewise help cellular structures to move.

Cullgen Announces “Featured Article” Publication of First in Class TRK Protein Degraders in Journal of Medicinal Chemistry

The Pharma Data

TRK fusion proteins have been found across a wide range of human malignancies, including lung cancer, colorectal cancer, and soft tissue sarcoma. In addition, acquired drug resistance has been reported in patients after treatment with approved TRK protein inhibitors. 16, 2020 09:20 UTC.

Biorad Mini Protein 3 System Glass Plates 5/Pack

BioTech 365

AU $62.70End Date: Wednesday Sep-2-2020 4:01:02 ESTBuy It Now for only: AU $62.70Buy It Now | Add to watch list Biotech365 : Biorad Mini Protein 3 System Glass Plates 5/Pack BioMarketplace You want to propose your products or a Biotech … Continue reading → #BioMarketplace #BioMarketplace_AU #Biorad

Stopping lethal lung damage from the flu with a natural human protein

Scienmag

Animal study shows treatment blocks inflammation and protects lungs without killing the flu virus COLUMBUS, Ohio – The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests.

Gyros Protein Technologies Introduces Gyrolab AAVX Titer Kit to Support Cell and Gene Therapy Market

BioTech 365

#news #biotech New insights into the coronavirus spike protein could inspire vaccine development

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New insights into the coronavirus spike protein could inspire vaccine development.New insights into the coronavirus spike protein could inspire vaccine development aliu Wed, 09/23/2020 – 06:27 from … Continue reading → #news

New method identifies antibody-like proteins with diagnostic and therapeutic potential for SARS-CoV-2

Scienmag

Antibody-like proteins that capture and neutralize SARS-CoV-2 Scientists have used a new high-speed, in vitro selection method to isolate 9 antibody-like proteins (ALPs) that bind to the SARS-CoV-2 virus – 4 of which also exhibited neutralizing activity – within 4 days, according to a new study.

Global Protein Therapeutics Market (2020 to 2025) – by Component, Therapy Area, Function & Region – ResearchAndMarkets.com

BioTech 365

DUBLIN–(BUSINESS WIRE)–The “Protein Therapeutics Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2020-2025” report has been added to ResearchAndMarkets.com’s offering. The global protein therapeutics market grew at a CAGR of around 7% during 2014-2019.

IL-21 protein a key part of immune response to central nervous system infections

Scienmag

— Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system. HERSHEY, Pa. The results of their recent study support further investigation into using IL-21 as a therapeutic agent for persistent central nervous system infections. CD4 T […]. Infectious Emerging Diseases Immunology/Allergies/Asthma Infectious/Emerging Diseases Medicine/Health

#news #biotech Genetic study of proteins is a breakthrough in drug development for complex diseases

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Genetic study of proteins is a breakthrough in drug development for complex diseases.An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative … Continue reading → #news