Lilly puts more money into protein degradation

Bio Pharma Dive

The pharma has struck its second research pact focused on drugs that break down harmful proteins in as many years, this time with California biotech Lycia Therapeutics

Evaluating methods targeting Protein-Protein Interactions

Pharma Phorum

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins.


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Protein folding in times of oxygen deficiency


Proteins often consist of hundreds or thousands of individual parts, the amino acids. However, protein molecules would not be able to fulfill their task as a long filament flapping back and forth. Chemistry AND Physics deficiency folding oxygen protein times

Novartis-linked startup launches with technology designed to remove ‘destroy’ tags on helpful proteins

Bio Pharma Dive

Vicinitas and its protein-stabilizing research have attracted $65 million from a group of investors that includes a16z, Deerfield and GV

AbbVie, targeting a well-known protein family, expands a partnership into neuroscience

Bio Pharma Dive

It’s the second deal in as many years between AbbVie and Sosei Heptares, which together have been trying to develop drugs that target so-called G protein-coupled receptors

Decoding protein assembly dynamics with artificial protein needles


Protein assembly is essential for the formation of ordered biological structures, but imagine engineering one! This is exactly what researchers at Tokyo Tech have now accomplished with protein needles. Biology Artificial assembly Decoding dynamics needles protein

Protein supplement helps control Type 2 diabetes


Drinking a small amount of whey protein before meals has been shown to help people with type 2 diabetes control their blood sugars. Social & Behavioral Science control Diabetes helps protein supplement type

Balancing protein in your diet could improve water quality


Balancing how much protein you eat with the amount your body needs could reduce nitrogen releases to aquatic systems in the U.S. Credit: Courtesy Maya Almaraz Balancing how much protein you eat with […]. Technology and Engineering Balancing diet improve protein quality water

Artificial muscles made of proteins


Stefan Schiller and Dr. Matthias Huber from the University of Freiburg’s livMatS Cluster of Excellence have succeeded in developing a muscle solely on the basis of natural proteins. Latest News Artificial muscles proteins

Deep learning reveals how proteins interact


Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. Biology deep interact learning proteins reveals

Identifying individual proteins using nanopores and supercomputers


The amount and types of proteins our cells produce tell us important details about our health and how our bodies work. But the methods we have of identifying and quantifying individual proteins are inadequate to the task.

How can a protein help us remember?


Studying fruit flies, they found that the Apterous (Ap) protein plays a crucial double role in retaining memories. Biology protein rememberTokyo, Japan – Researchers from Tokyo Metropolitan University have gained insights into the biochemistry of long-term memory.

Without ‘work-life balance,’ this protein may promote disease


COLUMBUS, Ohio – A family of proteins that have a role in ensuring many types of cells move and maintain their shape may promote disease when they act like workaholics and disrupt the cellular environment, new research suggests. Latest News balance Disease promote protein worklife

BETting on COVID-19: Study probes role of BET proteins in coronavirus infection


SAN FRANCISCO, CA—A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and extraterminal (BET) proteins, might be a way to fight COVID-19. Biology BET betting coronavirus COVID19 infection probes proteins role study

Unexpected protein could play role in common brain disorder


Scientists have known for years that amyloid fibrils — fibrous, ropelike structures formed by closely linked protein molecules — are present in the brains of patients with Alzheimer’s and Parkinson’s diseases and likely play a role in the progression of these disorders.

Newly discovered protein in fungus bypasses plant defenses


April 25, 2022—A protein that allows the fungus which causes white mold stem rot in more than 600 plant species to overcome plant defenses has been identified by a team of U.S. April 25, 2022—A protein that allows […]. Pullman, Wash.,

Touting a new way to drug an all-important family of proteins, a startup launches with $100M

Bio Pharma Dive

Backed by some of biotech's most powerful investors, Septerna is looking to usher in the next chapter of medicines that act on G protein-coupled receptors

Gene important in soybean protein content found after 30-year search


Soybeans outmatch all other legumes as the protein powerhouses of the plant kingdom, providing a key protein source for humans and livestock around the world. Social & Behavioral Science 30year Content gene important protein search SoybeanURBANA, Ill.

Oral Protein / Peptide-based Drugs: Addressing Key Unmet Needs Across Disease Indications

Roots Analysis

Orally administrable protein / peptide-based therapeutics offer several advantages including, effective treatment of numerous clinical conditions and degenerative disorders. Pipeline Overview of Oral Peptide and Protein-based Therapeutics. Oral Protein / Peptide-based Drugs.

New Machine Learning maps the potentials of proteins


The biotech industry is constantly searching for the perfect mutation, where properties from different proteins are synthetically combined to achieve a desired effect. Social & Behavioral Science learning machine maps potentials proteins

Uncovering warped protein interactions in cancer


Scientists at Emory have revealed widespread distortions of a cell’s protein interaction machinery resulting from cancer-causing mutations. One reason why a mutation is tumorigenic is the altered network of protein-protein […]. Latest News cancer interactions protein Uncovering warpedThey developed a process resembling ground-penetrating radar, for its ability to map the hidden landscape of anticancer drug opportunities. The results are published in Cell.

Disarming a blood-clotting protein prevents gum disease in mice


Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

Protein protects brain cells most impacted by glaucoma


March 1, 2022) — A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report. March 1, 2022) — A ubiquitous protein called sigma 1 receptor, […].

Protein structure offers clues to drug-resistance mechanism


CAMBRIDGE, MA — MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. Medicine & Health clues drugresistance mechanism offers protein structure

Imaging solves mystery of how large HIV protein functions to form infectious virus


Now, a team of scientists from the Salk Institute and Rutgers University have for the first time determined the molecular structure of HIV Pol, a protein that plays […]. Medicine & Health form functions HIV imaging infectious large mystery protein solves virus

Bioproduction Breakthrough: New method for developing Pichia pastoris yeast strains with high productivity of useful proteins


A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (1) in order to increase its secretory production of useful proteins (2).

Viral proteins join forces to lower plants’ defense ‘shields’


New research, led by Washington State University scientists, into how viral proteins interact and can be disabled holds promise to help plants defend themselves against viruses—and ultimately prevent crop losses. Latest News defense forces join plants proteins shields viral

Air Protein: The Alt Meat Startup Making Plant-Based Protein Out of Thin Air


California-based startup Air Protein developed an alt meat called Air Meat, which is made using microbes that turn recycled carbon dioxide (CO2) into protein. So, how does the company make alt protein out of thin air?

New insights of how the HIV-1 assembles and incorporates the Env protein


Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag’s N-terminal matrix domain. BIRMINGHAM, Ala.

AI-designed protein awakens silenced genes, one by one


By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Biology AIdesigned awakens Genes protein silenced

Is Protein Coffee Healthy and Which Companies Sell it?


Protein coffee is currently trending on the social media platform TikTok, with the hashtag gaining nearly ten million views. Otherwise known as “proffee,” the drink is the latest protein-enhanced beverage, following iced tea and even beer. What is Protein Coffee?

Gladstone and UCSF scientists discover BET protein role in Covid-19

Pharmaceutical Technology

Researchers at Gladstone Institutes and UC San Francisco (UCSF) have discovered in a study that bromodomain and extraterminal (BET) proteins are vital for the body to fight Covid-19 infection. . These findings indicated that BET proteins have a vital role in enabling and combating Covid-19.

Study details changes in omicron’s spike protein


An international team of scientists has determined the precise structural changes in the spike protein of the omicron variant. Biology details omicrons protein Spike study

Measuring levels of proteins in eye fluid may accurately predict need for lifelong macular degeneration therapy


Medicine & Health accurately degeneration eye Fluid levels lifelong macular Measuring predict proteins therapy

AF2Complex: Researchers leverage deep learning to predict physical interactions of protein complexes


From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible. Protein function […]. Chemistry AND Physics AF2Complex complexes deep interactions learning leverage Physical predict protein researchers

DNA 70

Advanced microscopes help scientists understand how cells break down proteins


Proteins are the building blocks of all living things. A vast amount research takes place on how these proteins are made and what they do, from enzymes that carry out chemical reactions to messengers that transmit signals between cells.

Stress protein in fibroblasts may be a good target for future cancer drugs, Penn study finds


Cancer cancer Drugs fibroblasts finds future good Penn protein stress study target

Targeting a human protein to squash SARS-CoV-2 and other viruses


Medicine & Health human protein SARSCoV2 squash targeting virusesMore than two years into the COVID-19 pandemic, people are realizing that the “new normal” will probably involve learning to co-exist with SARS-CoV-2.

Genetically modified proteins convert carbon nanotube to programmable optoelectronic device


Russian researchers and their international collaborators have developed a full-function bioelectronic photocell using one molecule of a fluorescent protein attached to a carbon nanotube. When exposed to light, the system can change its electronic properties and operate either as a spotlight or memory cell depending on how the protein is attached to the tube. Technology and Engineering carbon convert device genetically modified Nanotube optoelectronic Programmable proteins

Suffering from psoriasis? Blame this trio of proteins


Medicine & Health Blame proteins psoriasis Suffering trioLA JOLLA—About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes.

Intracellular temperature sensors: Protein complex exhibits temperature-sensitive activity


Osaka, Japan – One degree (Celsius) can make a difference: a team of investigators led by Osaka University has demonstrated regulation of a critical protein complex that occurs only at physiological temperature.

Deep-learning algorithm aims to accelerate protein engineering


Machine learning algorithms assist in protein engineering by reducing the experimental burden of methods such as directed evolution, which involves multiple rounds of mutagenesis and high-throughput screening.

U of T researchers find trove of proteins that may influence cystic fibrosis


Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.