Rethinking Clinical Trials

JANUARY 9, 2024

It’s difficult to gauge what kind of bias this introduces. Tags #pctGR, @Collaboratory1 The post Grand Rounds Biostatistics Series January 5, 2024: Methods for Handling Missing Data in Cluster Randomized Trials (Rui Wang, PhD; Moderator: Fan Li, PhD) appeared first on Rethinking Clinical Trials. That’s a great point.

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Trials Clinical Trials Clinical Trials Research 278

Rethinking Clinical Trials

MARCH 15, 2023

Mixed-effects models or Generalized Estimating Equations (GEE) are the most common analysis methods for clustered randomized trials, but when informative cluster size is present, both are bias. The occurrence of informative cluster size has never formally been evaluated to the presenter’s knowledge. .

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Trials Clinical Trials Clinical Trials Research 130

Rethinking Clinical Trials

DECEMBER 14, 2022

The patient randomized trial is always preferable; cluster randomized trials should only be used when there is no other choice because CRTs will always require a larger sample size, have higher risks of bias, be more vulnerable to chance imbalance between arms, and are more complicated to design and analyze. pctGR, @Collaboratory1.

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Trials Clinical Trials Clinical Trials Medicine 130

Rethinking Clinical Trials

DECEMBER 20, 2023

This is a really important point because we know that providers have bias, and it is the providers who do not approach women for enrollment. -Have you looked at the differential recruitment approaches between provider led and EHR-led approaches? Can we use blinded HER-led recruitment efforts to identify participants?

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Rethinking Clinical Trials

NOVEMBER 16, 2022

For investigators and health systems, there are substantial risks and burdens of data sharing with unclear benefits. Two takeaways: 1. Look beyond informed consent processes to fulfill obligations of respect when sharing individual level data from PCTs. pctGR, @Collaboratory1.

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Clinical Trials Clinical Trials Trials Research 246

Rethinking Clinical Trials

JANUARY 31, 2024

How do you mitigate bias because of incomplete data? Tags #pctGR, @Collaboratory1 The post Grand Rounds January 26, 2024: Advancing the Safe, Effective and Equitable Use of AI in Healthcare (Mark Sendak, MD, MPP; Suresh Balu, MD, MBA) appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

JUNE 14, 2023

In any trial emulation, researchers encounter design emulation differences in addition to potential sources of bias. Tags #pctGR, @Collaboratory1 The post Grand Rounds June 9, 2023: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative (Shirley V.

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