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What to expect from drug discovery and development in 2023

Drug Discovery World

The invasion of Ukraine by Russia was devastating, and its effects were felt throughout pharma as supply chains were disrupted and companies had to pause any operations they were pursuing in those countries, limiting access to medicines in both the near and long term. Despite this, innovation still occurred.

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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

Dofetilide was found to inhibit the human Ether-à- go-go-Related Gene (hERG) encoding cardiac potassium channel, which mediates the repolarising current in the cardiac action potential (IKr). Communications Medicine, 2(1), Article 1: 1-16. Inhibition of hERG can lead to one of the most lethal arrhythmias, known as torsade de pointes.

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