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What to expect from drug discovery and development in 2023

Drug Discovery World

The modernisation of R&D models could be key to reducing spend on new drugs, a point that Deloitte makes about the need to transform the clinical trials process. At the height of the pandemic, DCTs were seen as a viable alternative to keeping the engines running on clinical trials when non-critical in-person care was paused.

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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

Dofetilide was found to inhibit the human Ether-à- go-go-Related Gene (hERG) encoding cardiac potassium channel, which mediates the repolarising current in the cardiac action potential (IKr). Inhibition of hERG can lead to one of the most lethal arrhythmias, known as torsade de pointes.

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