Drug Discovery World
MARCH 24, 2023
Efti As a first-in-class soluble LAG-3 protein targeting MHC Class II ligands on antigen-presenting cells (APC), efti is positioned to improve clinical outcomes from standard-of-care chemotherapy. Its activation of APCs (e.g., month median overall survival (mOS) improvement, statistically significant mOS improvements between 4.2
The Pharma Data
SEPTEMBER 10, 2021
Patients treated with a short course of five cycles of tremelimumab, an anti-CTLA4 antibody, over 16 weeks in addition to Imfinzi and chemotherapy experienced a 23% reduction in the risk of death versus a range of chemotherapy options (based on a hazard ratio [HR] of 0.77; 95% CI 0.65-0.92; 0.92; p=0.00304). Median OS was 14.0
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The Pharma Data
MARCH 31, 2023
months, Opdivo with chemotherapy reduced the risk of disease recurrence, progression or death by 32%, demonstrating a landmark three-year event-free survival (EFS) rate of 57% with Opdivo with chemotherapy compared to 43% with chemotherapy alone (Hazard Ratio [HR], 0.68; 95% Confidence Interval [CI], 0.49 With median follow up of 41.4
The Pharma Data
APRIL 16, 2021
Bristol Myers Squibb thanks the patients and investigators involved in the CheckMate -9ER clinical trial. In the CheckMate -9ER trial, Opdivo in combination with Cabometyx showed superior PFS, ORR and OS versus sunitinib, with a low rate of TRAEs leading to discontinuation. months, respectively; HR 0.51; 95% CI: 0.41
The Pharma Data
DECEMBER 29, 2020
(NASDAQ: REGN) today announced encouraging initial data from an ongoing Phase 1/2/3 clinical trial of the Regeneron antibody cocktail, casirivimab and imdevimab, in hospitalized COVID-19 patients requiring low-flow oxygen. Evaluation of its safety and efficacy is ongoing in multiple clinical trials. Yancopoulos , M.D.,
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