Re-assessing the risks of drug-induced arrhythmias during drug discovery
Drug Discovery World
AUGUST 15, 2023
Dofetilide was found to inhibit the human Ether-à- go-go-Related Gene (hERG) encoding cardiac potassium channel, which mediates the repolarising current in the cardiac action potential (IKr). PEFA involves pacing the heart with a sequence containing increasingly premature extra stimuli and recording the response elsewhere in the heart.
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