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Informatics helps virtual biotech bring compound to clinical trial

Drug Discovery World

With no in-house laboratory space, the company works closely with multiple international contract research organisations (CROs), including Axxam, which carry out all of the Libra R&D, from compound screening assays, to in vivo pharmacokinetic/pharmacodynamic and ADME work, as well as in vitro and in vivo pre-clinical safety assessments.

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AI use in repurposing drugs for Covid-19

Drug Discovery World

Clinical trials revealed eight out of nine predictions were correct. Today, there have been efficacy readouts from large randomised controlled clinical trials for nine of our predictions – eight of which we predicted correctly. Results from Recursion’s Covid-19 efficacy predictions following clinilcal trial readouts.

Drugs 59
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Taking a new approach to tackle neurodegenerative diseases

Drug Discovery World

New York-based Oligomerix is an emerging clinical-stage biotechnology company focused on developing disease-modifying therapeutics for neurodegenerative diseases characterised by aberrant tau protein ranging from rare tauopathies such as progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) to Alzheimer’s disease (AD).

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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

Consequently, electrophysiological techniques need to be developed that can provide better translation from small mammalian hearts into larger hearts and then on into human clinical trials. Figure 3: Electrograms (left panel) are recorded at increasingly short intervals between the stimuli (the ‘S1S2 interval’).

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