Remove Antibody Remove DNA Remove Hormones Remove Protein
article thumbnail

Leading innovators in isotropically modified heterocyclic compounds for the pharmaceutical industry

Pharmaceutical Technology

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. The most common heteroatoms are nitrogen (N), oxygen (O) and sulphur (S).

Antibody 130
article thumbnail

What Innovative Treatments For Metastatic Breast Cancer are being developed?

Find Me Cure

CDK4/6 inhibitors are used alongside hormone therapy. HER2 is a protein that plays an important role in cancer cell growth and is found on the surface of cancer cells in a very high quantity in about 10-20% of breast cancers. However, a combination of HER2-targeted antibody drugs and a chemotherapy drug can prove to be more potent.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

News from AACR 2024: Wednesday’s highlights

Drug Discovery World

Treatment of BRCA2-deficient but not wild-type DLD1 cells with BSM-1516 resulted in cell cycle arrest accompanied by DNA damage signalling and accumulation of chromatin-bound RPA32, a marker of ssDNA. LAE119 is a potent and selective PARP1 inhibitor and PARP1-DNA trapper.

HR 52
article thumbnail

Top 40 Best-Selling Oncology Drugs in 2023 by 2022 Data

XTalks

Why it did so well: Darzalex was the first human anti-CD38 monoclonal antibody approved by the FDA for multiple myeloma. Darzalex (Daratumumab) Darzalex 2022 Sales: $7.977 billion Company/Developer: Janssen Biotech, Inc., The worldwide net trade sales of Darzalex were $2.26 billion in the first quarter of 2023.

article thumbnail

ADC potential “standard of care” for some breast cancer patients

Drug Discovery World

The FDA has granted expanded approval for Gilead Sciences’ Trodelvy (sacituzumab govitecan-hziy) for patients with HR-positive/HER2-negative metastatic breast cancer who have received hormonal therapy and at least two additional therapies in the metastatic setting.

HR 52
article thumbnail

Top 40 Best-Selling Cancer Drugs in 2023 by 2022 Data

XTalks

Why it did so well: Darzalex was the first human anti-CD38 monoclonal antibody approved by the FDA for multiple myeloma. Darzalex (Daratumumab) Darzalex 2022 Sales: $7.977 billion Company/Developer: Janssen Biotech, Inc., The worldwide net trade sales of Darzalex were $2.26 billion in the first quarter of 2023.

article thumbnail

Research Roundup: Blood Test for Severe COVID-19 and More

The Pharma Data

The test valuates mitochondrial DNA levels. When mitochondrial DNA, normally found inside cells, in the mitochondria, spills into the bloodstream, it signals that a particular type of violent cell death is occurring. They measured the patients’ mitochondrial DNA levels on the first day of their hospital stays. and William E.