Medical Xpress

MAY 16, 2023

Cancer is caused by DNA changes that cause a cell to gradually change from benign to malignant. By studying the types of DNA changes and the consequences of the changes, important insights into the underlying biological processes were obtained. This can lead to metastases in other parts of the body.

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Drug Discovery World

MAY 11, 2023

The first DNA synthesised using Evonetix’s semiconductor chip technology has been delivered to the Department of Chemical Engineering and Biotechnology at the University of Cambridge. The DNA was delivered to Dr Jenny Molloy, Co-chair of the Engineering Biology Interdisciplinary Research Centre at the University of Cambridge.

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Medical Xpress

NOVEMBER 18, 2022

Rutgers scientists have developed a new approach to stopping viral infections: a so-called live-attenuated, replication-defective DNA virus vaccine that uses a compound known as centanamycin to generate an altered virus for vaccine development.

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DNA Vaccination Vaccine Scientist 91

pharmaphorum

JULY 20, 2022

It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.

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DNA Scientist Genome Genomics 116

The Pharma Data

NOVEMBER 25, 2022

AI tailors artificial DNA for future drug development. With the help of an AI, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells’ protein production. “First it was about being able to fully ‘read’ the DNA molecule’s instructions. .

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Scienmag

JUNE 26, 2022

The monumental global task to restore degraded ecosystems will need to include sophisticated technologies such as environmental DNA monitoring to understand and support the recovery of complex biospheres, international researchers say.

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DNA Research Engineer 91

Medical Xpress

FEBRUARY 22, 2023

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

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DNA Research Gene Protein 98

Pharma Times

NOVEMBER 29, 2022

Bill & Melinda Gates Foundation grant will boost potential of nanoparticle-formulated doggybone DNA

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Medical Xpress

FEBRUARY 22, 2023

A new research paper was published in Aging, titled "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

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DNA Genome Genomics Research 98

Medical Xpress

APRIL 17, 2023

A multi-institution study that included researchers from Stanford University, the University of California at San Diego, the University of Cambridge, the Fred Hutchinson Cancer Center and others has looked into the development of extrachromosomal DNA in patients with esophageal adenocarcinoma or Barrett's esophagus.

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DNA Development Research 89

Pharma Times

OCTOBER 4, 2022

University of Lincoln and the University of Sheffield are researching how DNA could be repaired

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Scienmag

JULY 19, 2022

Scientists have found that non-coding ‘junk’ DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the way of the replication and repair of our genome, potentially allowing mutations to accumulate.

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DNA Genome Genomics Scientist 68

STAT News

FEBRUARY 9, 2023

Or the baby girl who could have had a life-threatening reaction to anesthesia had researchers not sequenced her DNA ahead of time. They’ll tell you about the 3-month-old boy whose heart was failing until researchers pinpointed what was ailing him.

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Genetic Disease Genetics DNA Genome 119

BioPharma Reporter

FEBRUARY 6, 2023

AstraZeneca has cut the cost and time needed to complete DNA synthesis by integrating an assembly framework into Benchling.

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DNA Clinical Development Development 98

Medical Xpress

APRIL 28, 2023

A team of researchers at the Broad Institute of MIT and Harvard has developed a new approach to next-generation sequencing that detects genetic mutations within single molecules of DNA.

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Genetics DNA Research Development 89

Medical Xpress

NOVEMBER 17, 2022

BRCA1 (BReast CAncer Gene 1), a key gene that becomes faulty in some instances, leading to breast and ovarian cancer, plays an important role in the body's DNA repair mechanisms. BRCA1, once mutated, can cause cancer to develop.

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DNA Gene Production Development 119

BioPharma Reporter

FEBRUARY 2, 2023

mRNA pioneer BioNTech has completed construction of its first proprietary plasmid DNA manufacturing facility in Marburg, Germany.

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DNA Manufacturing 95

STAT News

JANUARY 10, 2023

Illumina, the largest maker of DNA sequencing technology, told investors exactly what they didn’t want to hear on Monday. For years, Illumina shares rose steadily as the company led the way on pushing down the costs involved in doing genetic research.

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DNA Genetics Research 105

Medical Xpress

APRIL 18, 2023

A combination of the PARP inhibitor olaparib (Lynparza) and the investigational ATR inhibitor ceralasertib showed clinical benefit in pediatric patients with solid tumors exhibiting DNA replication stress and/or DNA repair deficiencies, according to results from the phase I portion of the phase I/II AcSé-ESMART trial presented at the AACR Annual Meeting (..)

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DNA Trials 73

The Pharma Data

OCTOBER 28, 2022

Ancient viral DNA in mortal genome guards against infections. Viral DNA in mortal genomes, bedded there from ancient infections, serve as antivirals that cover mortal cells against certain present- day contagions, according to new exploration. The cell also follows the inheritable instructions and makes further contagion.

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Medical Xpress

MAY 4, 2023

In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people.

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DNA Scientist Medicine Research 98

XTalks

DECEMBER 14, 2022

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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Gene Editing Gene DNA Gene Sequencing 97

Scienmag

MAY 9, 2022

HOUSTON – (May 9, 2022) – When cells reproduce, the internal mechanisms that copy DNA get it right nearly every time. Rice University bioscientists have uncovered a tiny detail that helps understand how the process could go wrong.

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DNA 86

Scienmag

APRIL 7, 2022

Chemists integrated computer functions into rolling DNA-based motors, opening a new realm of possibilities for miniature, molecular robots. Nature Nanotechnology published the development, the first DNA-based motors that combine computational power with the ability to burn fuel and move in an intentional direction.

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DNA Development Engineer 91

Scienmag

NOVEMBER 30, 2021

30, 2021 — A new study led by University of California, Irvine researchers has confirmed a link between altered DNA repair and increased DNA damage associated with spinocerebellar ataxia type 7 (SCA7), a debilitating, sometimes deadly neurodegenerative condition causing movement disorders. Irvine, Calif.,

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DNA Research Medicine 92

BioPharma Reporter

NOVEMBER 29, 2022

Touchlight has secured a grant from the Bill & Melinda Gates Foundation for a research program aimed at demonstrating that its enzymatically produced novel DNA format can support a rapid, scalable, durable, and thermostable vaccine solution for future pandemics, particularly in low and middle income countries.

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DNA Vaccination Vaccine Research 98

Scienmag

JUNE 3, 2022

Researchers in Japan have discovered that the local DNA motion inside of human cells remains steady throughout interphase, where the cell grows and replicates its DNA for cell division. The study suggests that this steady-state DNA motion allows cells to conduct housekeeping tasks under similar environments during interphase.

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Medical Xpress

MARCH 23, 2023

DNA is our body's instruction manual. It contains all the information that our cells need to make proteins and other molecules vital for our development, growth and survival.

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Scienmag

JUNE 3, 2022

Of these various macromolecules that form droplets, DNA is quite interesting because it is predictable and programmable, which are qualities useful in nanotechnology. Recently, the programmability of DNA was used to construct and regulate DNA droplets […].

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DNA Life Science Regulation Research 75

Outsourcing Pharma

MAY 25, 2023

A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.

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DNA Clinical Trials Clinical Trials Development 52

Outsourcing Pharma

MAY 25, 2023

A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.

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DNA Clinical Trials Clinical Trials Development 52

Medical Xpress

DECEMBER 21, 2022

Researchers at the University of Tokyo have used artificial DNA to target and kill cancer cells in a completely new way. The method was effective in lab tests against human cervical cancer- and breast cancer-derived cells, and against malignant melanoma cells from mice.

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DNA Immune Response Research 75

pharmaphorum

MAY 17, 2023

Boundless Bio raises $100m for circular DNA cancer therapy Phil.Taylor Wed, 05/17/2023 - 07:56 Bookmark this

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DNA 52

STAT News

SEPTEMBER 16, 2022

Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells.

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pharmaphorum

AUGUST 23, 2021

The COVID-19 pandemic accelerated the development of mRNA-based vaccines, and its influence has now extended to DNA-based shots as well, with Zydus Cadila’s ZyCoV-D getting emergency use authorisation in India. Proponents of the approach claim that DNA vaccines may have advantages over other technologies like mRNA.

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DNA Vaccination Vaccine Genetic Engineering 98

Pharma Times

AUGUST 16, 2022

Researchers are invited to apply to receive DNA that has been synthesised using Evonetix’s platform

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Medical Xpress

NOVEMBER 30, 2022

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

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