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The evolution of assays for immuno-oncology research

Drug Discovery World

The first such research dates back to 1891, when William Coley attempted to inject heat-inactivated bacteria to treat osteosarcoma. Genetically engineered mouse models (GEMM) recapitulate the stromal biology of different human cancers including the tumour microenvironment that regulates the disease process. doi:10.15252/emmm.201606857pmid:[link]