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Considerations for Neuroscience Trials with Intrathecal Delivery and Other Methods of Direct CNS Administration

XTalks

A major obstacle for CNS drug developers is the inability to target therapies to the CNS broadly (for instance, a therapy that is orally bioavailable as a pill and has difficulty crossing the blood-brain barrier) and certain CNS regions more specifically. All facilities (such as lab, pharmacy, MRI, etc.) The patients are waiting!

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What does the FDA animal testing legislation mean for drug discovery? 

Drug Discovery World

Aliasger Salem, a professor at the University of Iowa’s College of Pharmacy, told NPR: “Companies need to be aware of the limitations of those technologies and their ability to identify or not identify potential toxicities.

Drugs 52
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Warrior's Secret

The Pharma Data

and could change how “bioavailable” the all-important EBM triggering nutrients are. Bioavailable is a word that scientists use to describe how easy it is for your body to use a nutrient…. Now imagine that instead of having to hang your head in shame at the pharmacy…. Or explain your embarrassing symptoms to your urologist….

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Accurate dosing: How to achieve maximum precision with poor-flowing products

Pharmaceutical Technology

The team required narrow nanoparticle size distribution with a short processing time and a stable low temperature milling profile.

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Small molecule API: Shining a spotlight on new innovations in milling

Pharmaceutical Technology

The team required narrow nanoparticle size distribution with a short processing time and a stable low temperature milling profile.

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Nanomilling: How the latest Dynamic Light Scattering (DLS) technology could revolutionise hydrophobic API production

Pharmaceutical Technology

The paper concludes by noting that the potential cost reductions generated in the production of highly bioavailable APIs, as well as improved quality control, can ultimately promote production of custom formulations. Full details of the research by Fribourg University, including methods, results, and discussion, can be found here.

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A winning combination: The benefits of micronization and containment in a single installation

Pharmaceutical Technology

Challenges for micronization Micronization has become an increasingly significant process in the pharmaceutical industry and is necessary to produce APIs with better solubility and improved bioavailability. A number of high-impact milling methods, including ball, hammer, pin, and disc mills, have been adopted to meet this need.