article thumbnail

Jupiter Neurosciences Makes Way in CNS Treatments with $11M IPO

XTalks

Jotrol overcomes these barriers using patented micellar technology, enhancing bioavailability and enabling therapeutically effective doses. Conventional resveratrol products often face challenges like poor absorption and significant gastrointestinal side effects.

article thumbnail

Triggering Bacterial Calcification to Combat MRSA

Scienmag

The conjugation with polysialic acid further enhances bioavailability and may facilitate penetration into biofilm-embedded bacterial communities, an Achilles heel for many antimicrobial agents. Moreover, this strategy illustrates the untapped potential of nontraditional antimicrobial mechanisms.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Evaluating Ethanol Use in Neonatal Medication Excipients

Scienmag

They elaborate on the discrepancy between nominal excipient volumes and actual bioavailable ethanol following administration, calling for precise measurement practices and standardized reporting protocols. The authors advocate for enhanced transparency in excipient disclosure and stricter regulatory oversight.

article thumbnail

THC Levels Become Undetectable in Cows Following Withdrawal Period After Hemp Byproduct Feeding

Scienmag

Analytical testing revealed the presence of cannabinoids in various biological matrices, including blood plasma, milk, and body tissues, underscoring the bioavailability of cannabinoids from hemp byproducts. Over a 28-day feeding period, the cows ingesting spent hemp biomass showed significant systemic absorption of cannabinoids.

article thumbnail

Expert Insights: Development and Manufacture of Highly Potent Oral Liquids

XTalks

Improved bioavailability can lead to a faster onset of therapeutic effects, which is especially valuable in conditions where prompt action is required. Advanced formulation techniques are often required to improve the solubility and bioavailability of these APIs. Dosing flexibility is another prominent advantage provided by PDFs.

article thumbnail

Obesity-Focused Metsera Launches IPO Amid Much Anticipation

XTalks

The HALO platform enhances peptide half-life, facilitating monthly dosing and titration-free regimens, while the MOMENTUM platform optimizes oral bioavailability. Metseras HALO platform and MOMENTUM oral peptide delivery platform were used to develop these candidates. billion in 2024 to $37.94

article thumbnail

Enhancing solubility of targeted protein degraders: Better strategies for bioavailability

Pharmaceutical Technology

Achieving good oral bioavailability for TPDs Rebecca Coutts is Senior Director of Pharmaceutical Development at PCI Pharma Services, a world leading CDMO providing integrated end-to-end drug development. Several strategies can be employed to mitigate these challenges, says Coutts. “We’re