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Arrayjet announces collaboration with Chemspace

Drug Discovery World

Compounds can be printed neat at 10mM in dimethyl sulfoxide (DMSO), and a unique data point is generated per target-ligand interaction. The technique is suited for targeting proteins and structured RNA, developing heterobifunctional degrader molecules (e.g., PROTAC), and training AI drug discovery models.

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Taking a new approach to tackle neurodegenerative diseases

Drug Discovery World

New York-based Oligomerix is an emerging clinical-stage biotechnology company focused on developing disease-modifying therapeutics for neurodegenerative diseases characterised by aberrant tau protein ranging from rare tauopathies such as progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) to Alzheimer’s disease (AD).

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Informatics helps virtual biotech bring compound to clinical trial

Drug Discovery World

With no in-house laboratory space, the company works closely with multiple international contract research organisations (CROs), including Axxam, which carry out all of the Libra R&D, from compound screening assays, to in vivo pharmacokinetic/pharmacodynamic and ADME work, as well as in vitro and in vivo pre-clinical safety assessments.

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AI use in repurposing drugs for Covid-19

Drug Discovery World

But along with this massive disruption came an opportunity: to apply our platform to researching the SARS-CoV-2 virus. Our goal was to quickly identify existing therapeutics that could be repurposed for Covid-19 treatment by screening a library of approved and late-stage development drugs against a disease model in our platform.

Drugs 59
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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

We suggest a new generation of screening assays, that better recapitulate the electrophysiology of the whole human heart, may allow better decisions across research and development. The models chosen can be surprisingly ‘under-evaluated’ given their powerful effect on the quality of research and development decisions.

Drugs 52