Pharmaceutical Technology

JULY 25, 2023

Astellas Pharma has entered a research partnership and licence agreement with PeptiDream for the discovery of new targeted protein degraders.

Protein 130

Protein Research 130

Bio Pharma Dive

JULY 28, 2022

Vicinitas and its protein-stabilizing research have attracted $65 million from a group of investors that includes a16z, Deerfield and GV.

Protein 256

Protein Research 256

pharmaphorum

MARCH 13, 2024

Basecamp Research launches BaseFold, a deep learning model that it says surpasses benchmark tool AlphaFold2 and should accelerate AI-based drug discovery.

Protein 89

Protein Research Drugs 89

Pharma Times

DECEMBER 20, 2023

Researchers from Johns Hopkins University School of Medicine have revealed new findings about a key pathological protein associated with Parkinson’s disease (PD), which could lead to new treatments. However, its relation to dopaminergic neuron death is unclear.

Protein 99

Protein Medicine Engineer Genetics 99

Medical Xpress

NOVEMBER 23, 2022

Researchers have identified a protein that, when present in high amounts in breast cancer tumors, is an indicator of whether DNA-damaging therapies will work or not.

Protein 98

Protein Research DNA 98

Pharmaceutical Technology

JUNE 15, 2023

Japan-based Astellas Pharma has entered a partnership with Cullgen to discover and develop multiple targeted protein degraders through the latter’s proprietary uSMITE targeted protein degradation platform, in a deal potentially worth $1.9bn. This method can target enzymes, transcription factors, scaffold proteins and more.

Protein 130

Protein Development Licensing Licensing 130

Medical Xpress

MARCH 27, 2023

In a new study, researchers examined how a country's number of published 3D protein structures for coronaviruses, including the one responsible for COVID-19, correlated with its economic output and population.

Protein 94

Protein Research 94

Medical Xpress

APRIL 18, 2023

A team led by UT Southwestern Medical Center researchers has discovered a protein that appears to be pivotal for traumatic heterotopic ossification (HO), a condition in which bone forms in muscles, tendons, and other soft tissues after traumatic injury or surgery.

Protein 75

Protein Research 75

pharmaphorum

AUGUST 5, 2021

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins. These regions are critical for optimal interactions between proteins.

Protein 126

Protein Gene Bioassay DNA 126

XTalks

MARCH 31, 2023

BMS researchers on the mission will study the crystallization of an assortment of their biologics medicines in microgravity. By growing high quality crystal structures of protein-based therapeutics under microgravity, researchers can gain better insights into their complex structures and stability.

Protein 97

Protein Research Development Manufacturing 97

Drug Discovery World

APRIL 17, 2024

Arvinas’ AR-V7-targeting PROTAC protein degrader is designed to target both AR-V7 and full-length AR. This strategic transaction also further validates our innovative PROTAC protein degrader platform and its potential to deliver new treatments.”

Protein 52

Protein Licensing Licensing Sales 52

Pharmaceutical Technology

MARCH 21, 2023

Gilead Sciences has exercised its option to exclusively license the investigational targeted protein degrader development candidate, NX‑0479, from clinical-stage biopharmaceutical company Nurix Therapeutics. GS-6791 is the first development candidate from the previous collaboration between Gilead Sciences and Nurix in 2019.

Protein 130

Protein Licensing Licensing Sales 130

Scienmag

FEBRUARY 14, 2022

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

Protein 87

Protein Research Engineer 87

Medical Xpress

DECEMBER 2, 2022

A researcher has for the first time profiled 6,000 sperm proteins that could help create a non-hormonal male contraceptive—while also building on key research linking sperm health to overall men's health.

Protein 75

Protein Research Hormones 75

Pharmaceutical Technology

MAY 15, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology in Pharmaceuticals: Oncolytic viral proteins. Sillajen and Advaxis are the other key patent filers of oncolytic viral proteins.

Protein 130

Protein Gene Genetics Gene Therapy 130

BioPharma Reporter

AUGUST 10, 2023

Evox Therapeutics, an exosome therapeutics company, has announced the publication of its research identifying novel exosome scaffold proteins that significantly improve drug loading into exosomes for therapeutic purposes.

Protein 52

Protein Research Drugs Development 52

Pharmaceutical Technology

FEBRUARY 16, 2023

Aqilion and Merck have entered an exclusive licence and strategic research partnership for the discovery, development and commercialisation of the transforming growth factor-β-activated kinase 1 (TAK1) protein-small molecule inhibitors.

Protein 147

Protein Development Sales Business Development 147

pharmaphorum

MARCH 14, 2024

On today’s pharmaphorum podcast, Glen Gowers, co-founder of Basecamp Research, gets into the company’s recent pre-print paper and how it improves upon AlphaFold 2, the current gold standard for protein folding prediction.

Protein 59

Protein Research 59

Medical Xpress

FEBRUARY 22, 2023

Medicines that are based on mRNAs and proteins—particularly vaccines and antibodies—are time-intensive and costly to make. The challenge is in producing the necessary mRNAs and proteins in large enough amounts at low cost.

Protein 75

Protein Medicine Production Antibody 75

Medical Xpress

DECEMBER 5, 2022

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

Protein 75

Protein Genetic Engineering Research Engineer 75

Drug Discovery World

FEBRUARY 12, 2024

million grant to engineer microbial cell factories to produce membrane proteins which will support future drug screening and sustainable chemical production. The Engineering Biology Mission Award was given by UK Research and Innovation (UKRI). for drug discovery research appeared first on Drug Discovery World (DDW).

Research 105

Research Drugs Engineer Protein 105

Drug Discovery World

FEBRUARY 13, 2024

It goes on to show that NX-2127, a potent targeted protein degrader with differentiated activity against BTK and IKZF1/3, can overcome this resistance across a broad range of acquired mutations. The post Protein degrader overcomes resistance in B-cell malignancies appeared first on Drug Discovery World (DDW).

Protein 52

Protein Medicine Scientist Research 52

Scienmag

APRIL 27, 2021

Credit: UT Southwestern Medical Center DALLAS – April 27, 2021 – Researchers with the Peter O’Donnell Jr. Scientists from the departments of […].

Protein 96

Protein Research Scientist Medicine 96

Pharmaceutical Technology

MARCH 17, 2023

The Lung Cancer Research Foundation (LCRF) has announced a new research partnership with Daiichi Sankyo and AstraZeneca. This collaboration is intended to fund up to three research grants that are focused on antibody-drug conjugates (ADCs) for improving the outcomes for lung cancer patients.

Research 246

Research Antibody Protein Trials 246

Scienmag

APRIL 18, 2022

From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible. Credit: (Photo: Jess Hunt-Ralston / Georgia Tech) From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible.

Protein 79

Protein DNA Research 79

Scienmag

JANUARY 6, 2022

Protein assembly is essential for the formation of ordered biological structures, but imagine engineering one! This is exactly what researchers at Tokyo Tech have now accomplished with protein needles.

Protein 79

Protein Engineer Regulation Research 79

Medical Xpress

MARCH 9, 2023

A research team at City University of Hong Kong (CityU) recently identified a protein that triggers the migration of liver and pancreatic cancer cells and metastasis and is correlated with shortening the survival time of patients. Cancer metastasis is a major cause of cancer-related death.

Protein 75

Protein Research 75

Medical Xpress

MARCH 8, 2023

A study published in the Journal of Orthopaedic Research has identified a bone matrix protein called Secreted phosphoprotein 24 kD (Spp24) that may help to treat osteosarcoma, the most common type of bone cancer.

Protein 94

Protein Research 94

XTalks

APRIL 26, 2022

California-based startup Air Protein developed an alt meat called Air Meat, which is made using microbes that turn recycled carbon dioxide (CO2) into protein. So, how does the company make alt protein out of thin air? So, how does the company make alt protein out of thin air?

Protein 97

Protein Branding Production Scientist 97

Drug Discovery World

MARCH 5, 2024

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored ‘dark side’ of the neuraminidase (NA) protein head.

Antibody 59

Antibody Protein Vaccination Vaccine 59

Medical Xpress

NOVEMBER 16, 2022

Researchers have found changes in the levels of particular proteins in people's blood up to two years before they were diagnosed with breast cancer.

Protein 75

Protein Research 75

Medical Xpress

APRIL 20, 2023

A team with the participation of researchers from the Institute for Advanced Chemistry of Catalonia (IQAC) of the Spanish National Research Council (CSIC) has revealed the structure of the protein responsible for Huntington's disease, a severe neurodegenerative pathology characterized by the progressive disorder of movement and cognitive function. (..)

Protein 98

Protein Research 98

Drug Discovery World

FEBRUARY 14, 2024

The researchers suggested that if this tool had been deployed at the start of the pandemic, it would have accurately identified which variants of SARS-CoV-2 had the highest escape potential. However, such achievements can only be achieved by leveraging research strengths, regulatory capabilities and technical platforms.

Protein 59

Protein Vaccination Vaccine Manufacturing 59

pharmaphorum

MARCH 13, 2024

Basecamp Research launches BaseFold, a deep learning model that it says surpasses benchmark tool AlphaFold2 and should accelerate AI-based drug discovery

Protein 115

Protein Drugs Research 115

Medical Xpress

MARCH 21, 2023

An international study led by the Molecular Physiology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) identifies new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer's disease.

Protein 98

Protein Gene Life Science Research 98

Medical Xpress

FEBRUARY 17, 2023

Researchers at the National Institutes of Health and their colleagues have found that a toxic protein made by the body called DUX4 may be the cause of two very different rare genetic disorders.

Protein 98

Protein Genetics Research 98

Scienmag

NOVEMBER 17, 2021

Chemical topology is a unique dimension for protein engineering. Over the past few years, the discovery of topological nontrivial proteins in nature has already revealed their many potential functional benefits, such as enhanced thermal/mechanical/chemical stability.

Protein 80

Protein Antibody Engineer Development 80