article thumbnail

Beam makes USD 120M bet; GRAIL and Quest announce the collaboration; Brain organoids mimic infant’s brains; Improvement in T cells to kill cancer

Delveinsight

The gene-editing technologies, which have reached the clinic, CRISPR, zinc finger nucleases, and TALENs, make their edits by nicking DNA at the target site. Cambridge, Massachusetts-based Beam aims to make more precise edits with genetic medicines, which employ base-editing. If they eliminated the T cells, the therapy stopped working.

DNA 52
article thumbnail

Ensuring reliable assays: Why the ideal microplate is an invisible one

Drug Discovery World

But it comes with surface charge that will absorb proteins, DNA, and other things, unless you do something to treat that surface. In the beginning, the predominant material used to make microplates was polystyrene – it’s very affordable and generally easily accessed and supplied.

Drugs 52
article thumbnail

Unlocking the potential of mRNA for the future treatment of rare diseases 

Drug Discovery World

The manufacturing process begins with the construction of a DNA vector into which the template from which the mRNA will be transcribed in vitro from, is inserted. At this stage, qPCR can be used to check for IVT efficiency, residual DNA contamination and adventitious agents such as microbes.