A new startup gets Takeda's backing to take complex genetic medicines 'off the shelf'

Bio Pharma Dive

Ensoma Therapeutics debuts with a lucrative alliance with the Japanese pharma and an unusual way to deliver genetic medicines into the body

Lilly pays $880M for Prevail, pushing further into genetic medicine

Bio Pharma Dive

The acquisition marks a significant bet by Lilly on gene therapy's potential to address tough-to-treat neurological disorders like Parkinson's disease

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Merck pays Seattle Genetics $1.7B as antibody cancer drugs continue comeback

Bio Pharma Dive

Merck's deal for Seattle Genetics' antibody-drug conjugate comes as Gilead agreed to acquire rival developer Immunomedics in the biotech industry's largest buyout of 2020

Genetic Vaccine Development for Infectious Diseases Summit

Pharma Phorum

A combination of urgent need, unprecedented investments, and advances in genetic engineering has allowed what was once mere speculation to become not only our reality, but our future. The post Genetic Vaccine Development for Infectious Diseases Summit appeared first on.

Researchers reveal genetic predisposition to severe COVID-19

Scienmag

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. Credit: S.Nersisyan et al. The results of the study were published in the journal Frontiers in Immunology.

Landmark study details sequencing of 64 full human genomes to better capture genetic diversity

Scienmag

Medicine & Health Biodiversity Bioinformatics Genetics Medicine/Health Molecular Biology

FDA approves Regeneron drug for rare, genetic form of high cholesterol

Bio Pharma Dive

The biotech set an average annual price of $450,000 for the first-of-its-kind drug, which treats a condition that affects about 1,300 people in the U.S.

Genetics and the COVID-19 pandemic

Scienmag

ROCKVILLE, MD — With the COVID-19 pandemic still raging worldwide, members of the American Society of Human Genetics (ASHG) are working to understand how the virus spreads and infects people, why there is so much variability in susceptibility and severity, and where to look for potential therapeutics. Infectious Emerging Diseases Genetics Infectious/Emerging Diseases Medicine/Health Public Health Virology

Researchers release analysis of largest, most diverse genetic data set

Scienmag

Data demonstrates new increased diversity in genetic studies and provides new insights into population-specific diseases Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority populations. Medicine & Health Bioinformatics Cardiology Genes Genetics Medicine/Health

Plant genetic engineering to fight ‘hidden hunger’

Scienmag

Agriculture Agricultural Production/Economics Biology Biotechnology Food/Food Science Genetics Molecular Biology Nutrition/Nutrients Plant Sciences

Biologists create new genetic systems to neutralize gene drives

Scienmag

Two active genetics strategies help address concerns about gene-drive releases into the wild Credit: Ana Silva In the past decade, researchers have engineered an array of new tools that control the balance of genetic inheritance.

Genetic exchange discovered in anciently asexual rotifers

Scienmag

Agriculture Biodiversity Bioinformatics Biology Biotechnology Computer Science Evolution Genetics Marine/Freshwater Biology Population BiologyCredit: E.A. Mnatsakanova and O.A.

Genetic services can overcome rare disease trial challenges: InformedDNA

Outsourcing Pharma

A leader from the genetic solutions firm explains how genetic testing and counseling can help trial teams form more beneficial connections with patients.

Dresden scientists help setting new standards for cutting-edge genetic research

Scienmag

Biology Cell Biology Computer Science GeneticsCredit: © DKFZ Heidelberg Genomics, transcriptomics, proteomics, metabolomics, and others… The “omics” technologies keep revolutionizing medicine and biomedical sciences.

Low genetic diversity in two manatee species off South America

Scienmag

Genetic studies can help determine the conservation status of marine animals, identifying threats […]. Agriculture Biodiversity Biology Ecology/Environment Evolution Genetics Marine/Freshwater Biology Population Biology Zoology/Veterinary Science

Genetic background may affect adaptions to aging

Scienmag

— How we adapt to aging late in life may be genetically influenced, according to a study led by a psychologist at the University of California, Riverside.

Eating habits partly down to your genetics, finds new study

Scienmag

Your food intake patterns are partly under genetic control, according to the latest research from researchers at King’s College London, published today in the journal Twin Research and Human Genetics. Medicine & Health Cholesterol Diabetes Diet/Body Weight Genetics Medicine/Health Metabolism/Metabolic Diseases Nutrition/Nutrients

A genetic shortcut to help visualize proteins at work

Scienmag

Biology Cell Biology Genetics

Genetic gains for better grains

Scienmag

Biology Agriculture Developing Countries Food/Food Science Genes Genetics Plant SciencesCredit: © 2020 KAUST An African millet crop could be improved for growth in the dry, arid lands of Saudi Arabia by using information about its genome. Fonio is already well-adapted to this environment but has not had as much domestication as the major cereal crops, such as wheat, rice and maize. Gene targeting could […].

New statistical method exponentially increases ability to discover genetic insights

Scienmag

Pleiotropy analysis, which provides insight on how individual genes result in multiple characteristics, has become increasingly valuable as medicine continues to lean into mining genetics to inform disease treatments. Medicine & Health Genetics Medicine/HealthPrivacy stipulations, though, make it difficult to perform comprehensive pleiotropy analysis because individual patient data often can’t be easily and regularly shared between sites. However, a […].

Parasites’ dispersal capacity and rates of genetic introgression–a study

Scienmag

Partners in crime: genetic collaborator may influence severity of the rare disease, NGLY1

Scienmag

Credit: Photo credit: Charlie Ehlert/University of Utah Health In 2012, four-year-old Bertrand Might became the first-ever patient diagnosed with a rare genetic disorder called N-glycanase (NGLY1) deficiency. Medicine & Health Genes Genetics Medicine/Health

Ancestry study explores COVID-19 genetic risks

Outsourcing Pharma

The online DNA network has delved into self-reported data of more than 563,000 US adults to help identify genetic risk of infection and severe outcomes.

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NIH researchers identify new genetic disorder that affects brain, craniofacial skeleton

Scienmag

Analysis of patients with rare condition uncovers key pathway for human development Credit: Werner lab, NIDCR Researchers at the National Institutes of Health have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart and facial features.

Large-scale study finds genetic testing technology falsely detects very rare variants

Scienmag

A technology that is widely used by commercial genetic testing companies is “extremely unreliable” in detecting very rare variants, meaning results suggesting individuals carry rare disease-causing genetic variants are usually wrong, according to new research published in the BMJ. Biology Breast Cancer cancer Diabetes Diagnostics Genes Genetics Medicine/Health Metabolism/Metabolic Diseases

Sophia Genetics launches AI tool to find COVID-19 ‘unknowns’

Pharma Phorum

Swiss medical data specialist Sophia Genetics has launched a platform that will sift through data generated at more than 1,000 hospitals around the world to try to work out how the COVID-19 pandemic will evolve in the coming months and years.

Penn Medicine researchers discover a rare genetic form of dementia

Scienmag

Credit: Edward Lee PHILADELPHIA — A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. Medicine & Health Alzheimer Cell Biology Death/Dying Genetics Medicine/Health Mortality/Longevity Neurobiology

Genetic testing cost effective for newly diagnosed GIST

Scienmag

However, because this rare type of cancer is caused by different genetic mutations, imatinib does not help all patients equally. Medicine & Health cancer Gastroenterology Genetics Internal Medicine Medicine/Health

Are corals genetically equipped to survive climate change?

Scienmag

Atmospheric Science Biology Climate Change Ecology/Environment Genetics Marine/Freshwater BiologyCredit: This figure appears in the publication in Molecular Biology and Evolution. In 1998, ocean temperatures soared, and the world experienced its first significant coral bleaching event.

Genetic markers show Pacific albacore intermingle across equator

Scienmag

– Analyzing thousands of genetic markers in albacore tuna from the Pacific Ocean, researchers at Oregon State University have learned that just seven dozen of those markers are needed to determine which side of the equator a fish comes from.

Genetic disposition protects immune system from aging

Scienmag

Study reveals a previously unknown function of a human gene Credit: Lorenzo Bonaguro A genetic disposition that plays a role in the development of the heart in the embryo also appears to play a key role in the human immune system.

#news #biotech Chickpea genetics reduce need for chemicals

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Chickpea genetics reduce need for chemicals.In recent years, hummus has become a pop culture food phenomenon, drawing praises from dieticians for the health benefits and chefs for … Continue reading → #news

Toxins from one bacterial species contribute to genetic diversity of others

Scienmag

Infectious Emerging Diseases Biology Genetics Infectious/Emerging Diseases Medicine/Health MicrobiologyBacterial toxins that cause mutations in surviving cells profoundly shape bacterial diversity and could contribute to antibiotic resistance A toxin produced by bacteria as a defence mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.

#news #biotech Cataloguing genetic information about yams

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Cataloguing genetic information about yams.Yams are a staple food in West Africa, which produces over 90% of the world’s yams each year.

64 human genomes as new reference for global genetic diversity

Scienmag

Publication in Science Credit: David Porubsky, University of Washington In 2001, the International Human Genome Sequencing Consortium announced the first draft of the human genome reference sequence.

The genetics of blood: A global perspective

Scienmag

Biology Genetics Hematology Medicine/HealthWhat’s the risk of different human populations to develop a disease? To find out, a team led by Université de Montréal professor Guillaume Lettre created an international consortium to study the blood of hundreds of thousands of people worldwide. In one of the largest studies of its kind, published today in Cell, close to 750,000 […].

Scientists develop genetic ‘monitors’ that detect when genes are active

Scienmag

New genetic sensors, developed by scientists at University of Warwick and Keele University, could function as a lab test device and even as a live monitoring system inside living cells The innovative system can detect when a specific gene in a cell is active – instead of only detecting its presence The technology is based […]. Biology Cell Biology Gene Therapy Genes Genetics

Genetic adaptation to climate change is swift in crop pests

Scienmag

Agriculture Biology Climate Change Earth Science Ecology/Environment Gene Therapy Genes Genetics Parasitology

Seattle Genetics stays step ahead of rivals with bladder cancer data

Bio Pharma Dive

Data confirming the company's drug Padcev can extend the lives of bladder cancer patients should strengthen its position with regulators, although Immunomedics is close behind with a competing treatment

Genetic eraser: Newly developed technology precisely and rapidly degrades targeted proteins

Scienmag

Technology and Engineering Biology Biomedical/Environmental/Chemical Engineering Biotechnology Cell Biology Genes Genetics Molecular Biology Zoology/Veterinary Science

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New genetic analysis method could advance personal genomics

Scienmag

Computational method capable of decoding influence of rare variants Geneticists could identify the causes of disorders that currently go undiagnosed if standard practices for collecting individual genetic information were expanded to capture more variants that researchers can now decipher, concludes new Johns Hopkins University research.

Microbial genetics: A protean pathogen

Scienmag

The bacterium Helicobacter pylori is linked to increased risk of stomach cancer, and is genetically highly variable. A new study by researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich explores the role played by this diversity in the early phase of infection in adult humans. It is estimated that about half of the world’s population is infected […]. Biology Microbiology

Merck and Seattle Genetics Ink Two New Strategic Cancer Collaborations

BioSpace

Merck is making a major investment into Bothwell, Washington-based Seattle Genetics with two strategic oncology deals