Pharmaceutical Technology

DECEMBER 15, 2022

Therefore, there is also a significant need for new therapies that target the underlying cause of CFD that may offer a cure for patients living with severe disease, or for patients with genotypes such as dysfibrinogenemia and hypodysfibrinogenemia, who are often ineligible for treatment with HFCs.

Marketing 130

Marketing Production Genotype Development 130

Drug Discovery World

FEBRUARY 9, 2024

DDW recently hosted a webinar ‘Discover how iPSC derived cells can be used to support the development of drug and gene therapies’, supported by DefiniGEN. However, hepatoma lines may lack the key proteins essential for modelling. Can iPSC-derived hepatocytes be used to replace primary cells in toxicology? Watch on demand.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

SEPTEMBER 19, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling. Register for free here.

Gene Therapy 52

Gene Therapy Gene Development Protein 52

Drug Discovery World

SEPTEMBER 12, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling. Register for free here.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

AUGUST 25, 2023

However, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. Initial screening of treatments may utilise the highly proliferative Chinese Hamster Ovarian (CHO) or Human Embryonic Kidney (HEK) cell lines with the liver protein(s) of interest exogenously expressed.

Gene Therapy 52

Gene Therapy Gene Development Genotype 52

Drug Discovery World

SEPTEMBER 5, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling. Register for free here.

Development 59

Development Drugs Protein Genotype 59

Drug Discovery World

SEPTEMBER 26, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling. Register for free here.

Development 52

Development Drugs Protein Genotype 52