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Brain Awareness Week 2024: A Spotlight on Brain Health and New Treatments for Neurological Diseases

XTalks

This includes discussions on cutting-edge technologies and methodologies in brain research, such as neuroimaging, genetic engineering and artificial intelligence. This relates to neurological conditions like dementia and Alzheimer’s disease, which account for up to 70 percent of dementia cases.

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How mice with humanised immune systems are advancing cell-based immunotherapy

Drug Discovery World

For example, in randomised clinical trials of patients with non-small cell lung cancer (NSCLC), pembrolizumab has been shown to be effective in slowing down disease progression and improving survival rates 1. However, adverse effects such as cytokine release syndrome (CRS) and neurotoxicity still occur. Jespersen et al.

In-Vivo 52
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Using bispecific antibodies to advance cancer immunotherapy

pharmaphorum

In 2019, there were 57 bsAb candidates in clinical trials, against both haematological and solid tumours. They are also designed to have a short in vitro half-life, meaning that they will be cleared from a patient’s system within several hours. Simplified schematic overview of the proposed mechanisms of action for bsAbs.

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The use of base editing in stem-cell based therapies

Drug Discovery World

Increasing interest in CRISPR-Cas gene editing systems over recent years has delivered innovative developments in precision genome engineering technologies, holding enormous potential for applications across the healthcare sector. These cells present a highly scalable platform, capable of manufacturing advanced cellular therapeutics.