Grand Rounds February 3, 2023: Pragmatic Trials For Children With Congenital Heart Disease – Insights From The NITRIC Trial (Luregn Schlapbach, PhD, FCICM)
Rethinking Clinical Trials
FEBRUARY 13, 2023
This was not a dose finding trial and no nitrosothiol compounds were measured; the perfusionists in the study were not blinded; we allowed open label iNO; the choice of ventilator-free days as a primary endpoint can be criticized. There was no difference in the secondary outcomes either. There were a number of limitations.
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