Rethinking Clinical Trials

JANUARY 9, 2024

One cautionary note when creating the propensity weights using logistic regression is that there’s issues with collapsibility. It’s important to note that these approaches are not wedded to logistic regression, as long as we have a sensible model for the missingness. The EM algorithm helps with that problem.

Trials 275

Trials Clinical Trials Clinical Trials Research 275

Rethinking Clinical Trials

NOVEMBER 16, 2022

There are substantial logistical burdens in preparing data for sharing, meaningful risks of reidentification, and concern for biased or misleading analyses, with little demonstrated demand for PCT data and relatively low social value from PCT data reuse. pctGR, @Collaboratory1.

Clinical Trials 246

Clinical Trials Clinical Trials Trials Research 246

Rethinking Clinical Trials

FEBRUARY 16, 2023

There are consequences of notification, such as logistics and cost. Tags #pctGR, @Collaboratory1 The post Grand Rounds Ethics and Regulatory Series February 10, 2023: Informing and Consenting: What Are the Goals? (P. ICD-Pieces studied patients with chronic kidney disease (CKD), diabetes and hypertension. Pearl O’Rourke, MD; David S.

Clinical Trials 130

Clinical Trials Clinical Trials Medicine Trials 130

Rethinking Clinical Trials

DECEMBER 14, 2022

Five methodological arguments for stepped wedge CRTs are to improve rigor, to facilitate recruitment, to reduce the required sample size, to simplify logistics, and to reduce bias; however, most methodological arguments in favor of stepped wedge trials have a counter argument. pctGR, @Collaboratory1.

Trials 130

Trials Clinical Trials Clinical Trials Medicine 130

Rethinking Clinical Trials

MARCH 1, 2023

They are both approved and used widely in lung cancer, and combining two existing agents is logistically and clinically simpler. . – What was the rationale for the choice of study treatments (i.e., verses other immunotherapeutic agents)? There is a strong mechanistic rationale.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Packaging 130

XTalks

JUNE 28, 2023

million price tag of Elevidys, a one-time gene therapy. Ingram expects the launch to take a few months to pick up due to logistical and policy issues. It has taken Sarepta six years to develop Elevidys with several roadblocks in its journey, including two clinical holds due to safety concerns.

Gene Therapy 98

Gene Therapy Gene Protein FDA Approval 98

XTalks

APRIL 6, 2021

Where flour, pasta and other shelf-stable goods once sat in abundance quickly emptied to nothing but price tags. Hoarding, which is on the demand side, and supply side issues with labor, factories and logistics. Having that transparency in data is critical and it’s what’s leading the inevitable tech takeover of logistics.”.

Production 104

Production Sales Vaccination Vaccine 104