XTalks

FEBRUARY 27, 2024

Iovance Biotherapeutics’ Amtagvi (lifileucel) won US Food and Drug Administration (FDA) approval last week for the treatment of advanced melanoma, making it the first individualized tumor-infiltrating lymphocyte (TIL) therapy and the first T-cell therapy for a solid tumor to win US regulatory approval.

FDA Approval 52

FDA Approval Manufacturing In-Vivo Trials 52

Pharmaceutical Technology

APRIL 5, 2023

But access to these treatments continues to remain limited due to high price tags and variable availability across regions. But while companies continue studying allogeneic CAR-T therapies, including for their coveted use in solid tumours, such advancements remain challenging. But we need to recognize the challenge of solid tumours.

Gene Therapy 147

Gene Therapy Gene Engineer Production 147

XTalks

OCTOBER 12, 2022

Perfusion imaging done by MRI has been used to assess the intrinsic microvascular properties of tumors before, during and after treatment with anti-angiogenic and vascular-targeting agents. Anti-angiogenic drugs can slow the growth of tumors and sometimes even shrink tumors by preventing them from growing their own blood vessels.

Clinical Trials 93

Clinical Trials Clinical Trials Trials Drugs 93

XTalks

JANUARY 28, 2022

Kimmtrak has also become the first bispecific T cell engager to be FDA-approved for the treatment of a solid tumor. Kimmtrak has a price tag of $18,760 per vial, which amounts to a weekly dose. It targets gp100, which is a glycoprotein expressed in melanocytes and a tumor-associated antigen in melanoma.

FDA Approval 98

FDA Approval Development Licensing Licensing 98

XTalks

AUGUST 17, 2020

target cell antigens such as tumor cell antigens) on adjacent APCs, which are presented by an HLA (human leukocyte antigen) or an MHC (major histocompatibility complex) molecule on the cells. For their second molecule, the peptide was swapped out with a Wilm’s tumor 1 (WT1) peptide, and the third one has a KRAS peptide. 101, 102, 103).

Protein 98

Protein Engineer Immune Response In-Vivo 98

XTalks

JANUARY 19, 2024

The aim of these compounds is to deliver radiation directly to the tumor cells, minimizing damage to surrounding healthy tissues. The discussion centered on the evolving potential of alpha particle therapy for treating advanced and metastatic tumors. Alpha particles are helium nuclei consisting of two protons and two neutrons.

DNA 66

DNA Radiology FDA Approval Development 66

The Pharma Data

MAY 4, 2021

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Vaccination 40

Vaccination Vaccine Production Sales 40