Drug Discovery World

FEBRUARY 8, 2024

This is largely due to their highly stable Inverted Terminal Repeat (ITR) regions, as this secondary structure is prone to deletions during propagation in bacteria and cannot be read by standard Sanger sequencing. Dr O’Hara also provided an AAV plasmid preparation case study. Why are those important? How is the titer determined?

Gene Therapy 59

Gene Therapy Gene Bioinformatics Life Science 59

Drug Discovery World

OCTOBER 3, 2023

This is largely due to their highly stable Inverted Terminal Repeat (ITR) regions, as this secondary structure is prone to deletions during propagation in bacteria and cannot be read by standard Sanger sequencing. The post Guide to using AAV vectors in gene therapy appeared first on Drug Discovery World (DDW). Why are those important?

Gene Therapy 52

Gene Therapy Gene Life Science Bioinformatics 52

Drug Discovery World

APRIL 25, 2024

Cell line development is an essential underpinning of the drug development process, enabling teams to test, optimise and manufacture therapeutics at a commercial scale. For drug discovery and development, cell lines allow researchers to test the efficacy of therapeutics before moving into in vivo studies.

Development 59

Development Protein In-Vivo Life Science 59

Roots Analysis

OCTOBER 16, 2023

It involves the separation of unwanted particles from biological materials to obtain contaminant free products. Membrane Filters: Membrane filters are typically used for sterilization and removal of smaller impurities such as bacteria and viruses. are used to remove any residual bacteria, viruses, or endotoxins.

Bacteria 40

Bacteria Production Contamination Protein 40

Drug Discovery World

AUGUST 10, 2022

The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force. Although this type of contamination has not yet been reported in humans, RCVs can form rapidly growing T cell neoplasms, another type of cancer.

Manufacturing 98

Manufacturing Gene Genome Genomics 98