Scienmag

JULY 1, 2025

In a groundbreaking advancement poised to revolutionize the field of gene editing, researchers have unveiled a near-infrared (NIR) light activatable chemically induced CRISPR system, marking a pivotal step toward precise, spatiotemporal control of genome engineering.

Gene Editing 59

Gene Editing Gene Gene Therapy Genomics 59

Scienmag

JULY 7, 2025

In the rapidly evolving field of genome editing, precision remains the cornerstone for advancing therapeutic potentials and broadening biological understanding. The ability to selectively target pathogenic alleles without collateral cytosine modifications marks a critical step forward for patient-tailored genome surgery.

Genomics 59

Genomics Genome Genotype Engineer 59

Scienmag

JUNE 19, 2025

Published recently in Translational Psychiatry , this multi-ancestry genome-wide association study (GWAS) integrates single nucleotide polymorphism (SNP)-by-psychosocial interaction analyses to reveal previously unidentified genetic contributors to lipid metabolism.

Genetics 59

Genetics Genomics Genome Gene 59

Scienmag

JULY 4, 2025

In a groundbreaking study that promises to reshape our understanding of autism spectrum disorder (ASD), researchers have employed state-of-the-art single-cell genomic technologies to unravel the complex molecular alterations underlying dup15q syndrome—a genetic condition strongly linked to autism.

Gene Expression 52

Gene Expression Gene Genetics RNA 52

Scienmag

JUNE 27, 2025

The current investigation focuses on a cohort of 13 patients from Northeastern Brazil with identified HER2 mutations in NSCLC tumors, drawing attention not only to the presence of these mutations but also to their extensive genomic interplay with other oncogenic drivers. 28737 Image Credits: Copyright: © 2025 Nogueira et al.

Genetics 59

Genetics Genomics Genome Protein 59

Scienmag

JUNE 18, 2025

The approach exemplifies how coupling systematic mutagenesis with sophisticated computational modeling can unravel the complexity of the non-coding genome. This approach surpasses traditional in vitro assays by capturing the full complexity of chromatin landscape, three-dimensional genome architecture, and relevant cellular environments.

In-Vivo 80

In-Vivo Gene Expression Gene DNA 80

BioTech 365

JUNE 26, 2025

Baylor Genetics Applauds New Guidance from American Academy of Pediatrics for Genome and Exome Sequencing to be used as First-Tier Tests for Children with Certain Developmental Delays Baylor Genetics Applauds New Guidance from American Academy of Pediatrics for Genome and … Continue reading →

Genomics 52

Genomics Genome Genetics 52

Scienmag

JUNE 24, 2025

In the rapidly evolving realm of psychiatric genetics, a landmark review published on June 24, 2025, in Genomic Psychiatry elucidates the intricate relationships between polygenic scores for mood disorders and clinical outcomes across major psychiatric conditions.

Genetics 52

Genetics Genomics Genome Gene 52

Scienmag

JUNE 13, 2025

Singapore – Scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new artificial intelligence (AI)-based method called “Fragle” that makes tracking cancer easier and faster using blood tests. ” While existing methods have their strengths, they are often complex and expensive.

DNA 59

DNA Genomics Genome Genetics 59

Scienmag

JUNE 26, 2025

These breaks pose a serious threat to genomic stability, especially in neurons that are non-dividing and highly sensitive to DNA damage. The formation of these deleterious chromosomal alterations underscores a novel cytotoxic mechanism for cytarabine, connecting epigenetic regulation directly to genome integrity in neurons.

DNA 59

DNA Genomics Genome Regulation 59

Scienmag

JULY 16, 2025

Traditional taxonomic profiling methods rely heavily on comparing metagenomic reads against vast genomic reference libraries. These methods, while foundational, inherently suffer from a crucial bottleneck: the genomic underrepresentation of countless microbial species that dominate natural environments yet remain uncultured and unsequenced.

Genomics 69

Genomics Genome Gene Genetics 69

Scienmag

JULY 3, 2025

Subject of Research : Cells Article Title : scICE: Enhancing Clustering Reliability and Efficiency of Single-cell RNA Sequencing Data with Multi-Cluster Label Consistency Evaluation News Publication Date : 2-Jul-2025 Web References : DOI link: 10.1038/s41467-025-60702-8 Image Credits : Institute for Basic Science Keywords : Single cell sequencing, (..)

Gene Expression 81

Gene Expression Research RNA Gene 81

Scienmag

JULY 8, 2025

The researchers began by comparing the genomic sequences of the wild-type yellow fever virus and the 17D vaccine strain. The yellow fever virus genome consists of over 10,000 nucleotides encoding a polyprotein cleaved into multiple structural and nonstructural components.

Vaccination 59

Vaccination Vaccine Protein Genetics 59

Scienmag

JUNE 29, 2025

Recognizing this diagnostic gap, the collaborative research initiative spearheaded by the Carlos Simón Foundation and iPremom set out to harness advanced genomics and machine learning for more sensitive, timely detection.

Development 52

Development RNA Medicine Genomics 52

Scienmag

JULY 8, 2025

Intriguingly, these RNA molecules are derived from two principal sources: the human genome itself and the vast consortium of microbial species inhabiting the human body, collectively known as the microbiome. This paradigm shift broadens perspectives on inter-organ communication and systemic disease mechanisms mediated by the microbiome.

RNA 81

RNA Genomics Genome Research 81

Scienmag

JULY 14, 2025

The convergent evidence from proteomics and genomics reinforces the hypothesis that MDD fosters a distinct biological environment that accelerates typical neurodegenerative pathways implicated in Alzheimer’s disease. Article References : Diniz, B.S., Steffens, D.C.

Protein 59

Protein Genetics Biobanking Genomics 59

Scienmag

JUNE 16, 2025

The absence or malfunction of DIAPH1 disrupts this scaffold formation, leaving DNA vulnerable to persistent breaks that can drive genomic instability. The DIAPH1 protein facilitates the formation of γ-actin, a specialized polymer that acts as a dynamic scaffold stabilizing DNA at sites of damage to enable precise repair.

DNA 83

DNA Genetics Genomics Genome 83

Scienmag

JUNE 20, 2025

By harnessing machine learning algorithms capable of assimilating multi-dimensional datasets—including genomic, proteomic, imaging, and clinical parameters—the partnership members aim to pioneer predictive analytics that can preemptively identify patients at risk for adverse cardiovascular events and optimize treatment trajectories.

Research 88

Research Cardiology Medicine Genetics 88

Scienmag

JULY 19, 2025

The study harnesses the power of single-cell transcriptomics paired with genome-wide Mendelian randomization techniques to dissect the chemokine involvement at a cellular resolution, exposing a mosaic of immune dysregulation that was previously masked by bulk analyses. This study represents a powerful leap forward in that direction.

Genomics 52

Genomics Genome Genetics Insulin 52

Scienmag

JUNE 19, 2025

Unlike DNA, mRNA remains transient in the cytoplasm and avoids genomic integration, mitigating concerns regarding insertional mutagenesis and other long-term genetic alterations. The advantages of utilizing mRNA are profound. This transient expression can also be advantageous where temporary modulation of immune response is desired.

In-Vivo 52

In-Vivo Engineer Manufacturing RNA 52

Scienmag

JUNE 18, 2025

The mutation rs80359550 in BRCA2 identified in this cohort was associated with more than a tenfold increase in prostate cancer risk, underscoring the gene’s pivotal involvement in DNA repair pathways that, when dysfunctional, lead to genomic instability and tumorigenesis. In conclusion, the study led by Umarane et al.

Genetics 85

Genetics DNA Genotype Genomics 85

Scienmag

JUNE 17, 2025

Crucial to this breakthrough was the integration of cutting-edge genomic technologies with translational oncology expertise. One of the study’s notable aspects is the multidisciplinary collaboration spanning urology, oncology, genomics, and immunotherapy.

Genomics 59

Genomics Genome Clinical Trials Clinical Trials 59

Scienmag

JUNE 10, 2025

Integrating cutting-edge technologies like CRISPR-Cas9 gene editing allows for precise manipulation of tumor genomes within PDXs, enabling in-depth functional studies of oncogenic drivers and resistance pathways. To transcend current limitations, innovative next-generation PDX platforms are under development.

Research 59

Research Clinical Trials Clinical Trials Gene Editing 59

Scienmag

JUNE 30, 2025

Delving deeper, the researchers employed cell-type-specific genomic profiling, a technical tour de force allowing unparalleled insights into gene expression within excitatory neurons of the neocortex.

Gene Expression 80

Gene Expression Gene Regulation In-Vivo 80

Scienmag

JULY 18, 2025

It challenges long-held paradigms rooted in single-marker analyses and points toward a future where precision medicine is informed not only by genomic data but also by spatially resolved proteomic landscapes. In conclusion, the deployment of PathoPlex presents a transformative advance in the study of immune-mediated kidney disease.

Antibody 90

Antibody In-Vivo In-Vitro Research 90

Scienmag

JUNE 27, 2025

Notably, mice harboring the HBV genome developed severe liver cancer phenotypes only following DEN exposure, whereas HBV presence without the carcinogen failed to provoke significant hepatic injury or tumor formation.

Immune Response 90

Immune Response Research Genomics Genome 90

Scienmag

JUNE 18, 2025

Conversely, global DNA hypomethylation represents another hallmark of HCC epigenetics, resulting in genomic instability and reactivation of normally silenced transposable elements and oncogenes.

DNA 59

DNA Gene Expression Gene Gene Silencing 59

Scienmag

JULY 3, 2025

Notably, the study emphasizes the utility of CRISPR-Cas9-based functional genomics in identifying actionable cancer drivers and refining molecular targeted therapies. Future investigations might delineate combinatorial regimens pairing autophagy inhibitors with checkpoint blockade drugs, optimizing treatment efficacy and patient outcomes.

Regulation 59

Regulation Gene Gene Editing RNA 59

Scienmag

JUNE 17, 2025

Tedersoo’s research confronts this challenge head-on by leveraging molecular and genomic tools to overcome these traditional barriers. A cornerstone of this venture involves establishing guiding principles and standards for a DNA-based phylogenetic taxonomy, which would coalesce vast genomic datasets into a coherent classification framework.

DNA 72

DNA Genomics Genome Research 72

Scienmag

JULY 15, 2025

Integration with genomic and epigenomic data will also be crucial to decipher the multifactorial nature of metabolic health determinants. They advocate for prospective studies with longitudinal metabolic assessments spanning prenatal life through adulthood to validate and expand upon current findings.

Insulin 59

Insulin Gene Expression Research DNA 59

Drug Discovery World podcast

MARCH 13, 2025

This is the latest episode of the free DDW narrated podcast, titled The revolutionary impact of understanding genomics, which covers two articles written for DDW Volume 24 Issue 3, Summer 2023. In the first article, Evan Floden, CEO of Seqera Labs, examines how data sharing platforms are impacting cancer and genomics research.

Genomics 52

Genomics Genome RNA DNA 52

Scienmag

JUNE 24, 2025

The study combined advanced neuroimaging, genomic profiling, and neurochemical assays to identify distinct biomarker patterns that correlate with treatment responsiveness. Central to this advance is the multifaceted analysis of neurobiological signatures associated with AUD.

Gene Expression 52

Gene Expression Research Bioinformatics Genetics 52

Scienmag

JULY 5, 2025

Future research integrating genomic, microbiomic, and clinical data will be essential to decipher these multifaceted relationships. Given that schizophrenia has a significant heritable component, interactions between host genotype and microbial ecology might underlie susceptibility patterns and phenotypic variability.

Bacteria 59

Bacteria Research Genotype Bioinformatics 59

Scienmag

JULY 5, 2025

This approach leverages the power of genome-wide association studies (GWAS) data and addresses the multifaceted genetic architecture of mental health disorders, moving beyond candidate gene studies that often yield inconsistent results.

Genetics 59

Genetics Gene Regulation Gene Expression 59

Scienmag

JUNE 22, 2025

Integrating metabolic imaging, clinical nutrition, neurodevelopmental pediatrics, and even genomics could further unravel individualized responses to lipid supplementation, optimizing outcomes at the intersection of precision medicine and neonatal care. Moreover, this study sets the stage for expanded multidisciplinary collaboration.

Research 59

Research Development Production Medicine 59

Scienmag

JUNE 17, 2025

These might include genomic signatures, tumor mutational burden beyond MSI, neoantigen landscape assessments, or immune cell infiltration patterns within the tumor microenvironment. Integrating these parameters into clinical workflows could radically reshape therapeutic paradigms.

Research 59

Research Immune Response Trials Genomics 59

Scienmag

JULY 2, 2025

Additionally, further prospective trials are warranted to validate these findings and explore their utility in conjunction with emerging molecular and genomic biomarkers. Factors such as cost, accessibility, and expertise in interpreting dynamic PET/CT metrics must be addressed to realize widespread adoption.

Research 72

Research Genomics Genome Medicine 72