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Delivering on the promise of gene editing

Drug Discovery World

Inducing double strand breaks at unintended locations in the genome can lead to off-target genetic modifications that are difficult to predict and potentially deleterious. Complicating matters even more, researchers currently lack effective and reliable methods for detecting and measuring off-target genomic events.

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Optimising AAV capsid purification through improved analytics

Drug Discovery World

Svea Cheeseman , Refeyn, explains why better efficiency is needed to advance the production of viral vectors for use in gene therapies. Adeno-associated viruses (AAVs) are a promising, widely used vector for delivering gene therapies. Data were provided by the Cell and Gene Therapy Catapult (London, UK).

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The importance of glycan analysis and characterisation for biopharma

Drug Discovery World

This progress includes the expansion of genomic sciences and the ability to design cell bioprocessing platforms for biotherapeutics production that can be used to address previously unmet medical needs. Agilent’s next round of collaboration will look at cell and gene therapy glycan applications. The glycan database .

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