Containment Genome Packaging Reagent 
Drug Discovery World
DECEMBER 15, 2022
Inducing double strand breaks at unintended locations in the genome can lead to off-target genetic modifications that are difficult to predict and potentially deleterious. Complicating matters even more, researchers currently lack effective and reliable methods for detecting and measuring off-target genomic events.
Drug Discovery World
FEBRUARY 8, 2023
In AAV therapeutics, empty capsids are those that are not packaged with the therapeutic DNA. Partially-filled capsids may also be present, and contain packaged process-related impurities or truncated genetic material. Second, empty capsids are thought to impair therapeutic potency due to receptor competition.
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